Cloning and synthesis of infectious cardiovirus RNAs containing short, discrete poly(C) tracts

Duke, G M; Palmenberg, A C

doi:10.1128/jvi.63.4.1822-1826.1989

Cited by 120Viral Infections and Immunology ResearchAnimal Virus Infections StudiesVirology and Viral Diseases

Cloning and synthesis of infectious cardiovirus RNAs containing short, discrete poly(C) tracts

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Duke, G M, Palmenberg, A C·1989·Journal of Virology

DOI 10.1128/jvi.63.4.1822-1826.1989PMC PMC248463

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Abstract

Mengovirus RNA transcripts with 5' noncoding poly(C) tracts of C8, C12, and C13UC10 have been synthesized in vitro from cDNA clones and shown to be infectious to HeLa cells. A chimeric clone has also been constructed which links the 5' end from one mengovirus clone (299 nucleotides, containing C13UC10) to a 7,424-base fragment derived from the 3' end of encephalomyocarditis (EMC) virus. Progeny virus isolated after transfection with the clone-derived RNAs had the same poly(C) tracts, mengovirus-specific sequences, or EMC virus-specific sequences as the transcript from which it was derived. Although the cloned poly(C) tracts were considerably shorter than those found in viral RNA from mengovirus (C50UC10) or EMC virus (C115UCUC3UC10), the growth characteristics of the progeny viruses in HeLa cells were indistinguishable from those of the parental viruses, indicating the length of this tract does not play a significant restrictive role for cardiovirus infectivity in tissue culture.

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The polyC tract of the prototype elephant virus is shorter than reported for EMCV isolates such as the prototype Rueckert strain, but is on par with Mengo virus.
“While this polyC tract is shorter than reported for EMCV isolates such as the prototype Rueckert strain (C115UCUCCCUC10) [38], it is on par with Mengo virus (C50UC10) [39].”
From Zoological transmission of encephalomyocarditis virus in the United States: Virus evolution, host ecology, and capsid antigenicity derived from an outbreak (2026) · cites this paper as [39]

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Encephalomyocarditis viruses with short poly(C) tracts are more virulent than their mengovirus counterparts
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Authors: Duke, G. M., & Palmenberg, A. C.
Affiliations: University of Wisconsin–Madison (US)
ORCID: Palmenberg, A C
Venue: Journal of Virology
Publisher: American Society for Microbiology
Published: 1989-04
Volume: 63
Issue: 4
Pages: 1822-1826
ISSN: 0022-538X (ISSN-L)
1098-5514
DOI: 10.1128/jvi.63.4.1822-1826.1989
PMC: PMC248463
OpenAlex: W1519227646
Cited by: 120
References: 12
Citations by year: 2026: 2 · 2025: 3 · 2024: 3 · 2023: 5 · 2022: 5 · 2021: 2 · 2020: 2 · 2019: 2 · 2016: 3 · 2015: 4 · 2014: 3 · 2013: 4 · 2012: 1
FWCI: 5.02
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Journal of Virology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Allergy and Infectious Diseases (AI17331)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Viral Infections and Immunology Research
Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Virus Infections Studies
Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
Keywords: mengovirus, encephalomyocarditis virus, cardiovirus, viral RNA synthesis, in vitro transcription, cDNA cloning, chimeric viruses, HeLa cells
MeSH terms: Cloning, Molecular, Encephalomyocarditis virus, HeLa Cells, Humans, Mengovirus, Poly C, Polyribonucleotides, Virus Replication

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Cloning and synthesis of infectious cardiovirus RNAs containing short, discrete poly(C) tracts

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