The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Protective CD4+and CD8+T Cells against Influenza Virus Induced by Vaccination with Nucleoprotein DNA
Open accessAbstract
DNA vaccination is an effective means of eliciting both humoral and cellular immunity, including cytotoxic T lymphocytes (CTL). Using an influenza virus model, we previously demonstrated that injection of DNA encoding influenza virus nucleoprotein (NP) induced major histocompatibility complex class I-restricted CTL and cross-strain protection from lethal virus challenge in mice (J. B. Ulmer et al., Science 259:1745–1749, 1993). In the present study, we have characterized in more detail the cellular immune responses induced by NP DNA, which included robust lymphoproliferation and Th1-type cytokine secretion (high levels of gamma interferon and interleukin-2 [IL-2], with little IL-4 or IL-10) in response to antigen-specific restimulation of splenocytes in vitro. These responses were mediated by CD4+T cells, as shown by in vitro depletion of T-cell subsets. Taken together, these results indicate that immunization with NP DNA primes both cytolytic CD8+T cells and cytokine-secreting CD4+T cells. Further, we demonstrate by adoptive transfer and in vivo depletion of T-cell subsets that both of these types of T cells act as effectors in protective immunity against influenza virus challenge conferred by NP DNA.
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Citations
Cites
Direct Gene Transfer into Mouse Muscle in Vivo
Wolff, J. A., Malone, R. W., Williams, P., Chong, W., Acsadi, G., Jani, A., & Felgner, P. L. (1990) · Science · doi:10.1126/science.1690918 · Cited by 4,173
Cited by
Influenza vaccine: The challenge of antigenic drift
CARRAT, F., & FLAHAULT, A. (2007) · Vaccine · doi:10.1016/j.vaccine.2007.07.027 · Cited by 708
DNA vaccines: an historical perspective and view to the future
Liu, M. A. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00980.x · Cited by 468
Self-citationEpstein, S. L. (2006) · The Journal of Infectious Diseases · doi:10.1086/498980 · Cited by 295
Cellular immunity and memory to respiratory virus infections
Woodland, D. L., Hogan, R. J., & Zhong, W. (2001) · Immunologic Research · doi:10.1385/ir:24:1:53 · Cited by 97
Metadata
- Authors
- Ulmer, J. B., Fu, T.-M., Deck, R. R., Friedman, A., Guan, L., DeWitt, C., Liu, X., Wang, S., Liu, M. A., Donnelly, J. J., & Caulfield, M. J.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 1998-07
- Volume
- 72
- Issue
- 7
- Pages
- 5648-5653
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W2137681090
- Cited by
- 231
- References
- 1
- FWCI
- 11.67
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Protective CD4+and CD8+T Cells against Influenza Virus Induced by Vaccination with Nucleoprotein DNA. https://app.cochat.ai/papers/10.1128/jvi.72.7.5648-5653.1998
- The paper
- Ulmer, J. B., Fu, T.-M., Deck, R. R., Friedman, A., Guan, L., DeWitt, C., Liu, X., Wang, S., Liu, M. A., Donnelly, J. J., & Caulfield, M. J. (1998). Protective CD4+and CD8+T Cells against Influenza Virus Induced by Vaccination with Nucleoprotein DNA. Journal of Virology. https://doi.org/10.1128/jvi.72.7.5648-5653.1998
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
