The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.
Influenza vaccine: The challenge of antigenic drift
Open accessAbstract
Influenza continues to have a major worldwide impact, resulting in considerable human suffering and economic burden. The regular recurrence of influenza epidemics is thought to be caused by antigenic drift, and a number of studies have shown that sufficient changes can accumulate in the virus to allow influenza to reinfect the same host. To address this, influenza vaccine content is reviewed annually to ensure protection is maintained, despite the emergence of drift variants; however, it is not always possible to capture every significant drift, partly due to the timing of the recommendations. Vaccine mismatch can impact on vaccine effectiveness, and has significant epidemiological and economical consequences, as was seen most apparently in the 1997-1998 influenza season. To meet the challenge of antigenic drift, vaccines that confer broad protection against heterovariant strains are needed against seasonal, epidemic and pandemic influenza. In addition to the use of vaccine adjuvants, emerging research areas include development of a universal vaccine and the use of vaccines that exploit mechanisms of cross-protective immunity.
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Cites
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Cited by
Zost, S. J., Parkhouse, K., Gumina, M. E., Kim, K., Diaz Perez, S., Wilson, P. C., Treanor, J. J., Sant, A. J., Cobey, S., & Hensley, S. E. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1712377114 · Cited by 563
Illuminating viral infections in the nervous system
McGavern, D. B., & Kang, S. S. (2011) · Nature Reviews Immunology · doi:10.1038/nri2971 · Cited by 281
Early Archean origin of Photosystem II
Cardona, T., Sánchez‐Baracaldo, P., Rutherford, A. W., & Larkum, A. W. (2019) · Geobiology · doi:10.1111/gbi.12322 · Cited by 144
Ansaldi, F., Bacilieri, S., Durando, P., Sticchi, L., Valle, L., Montomoli, E., Icardi, G., Gasparini, R., & Crovari, P. (2008) · Vaccine · doi:10.1016/j.vaccine.2008.01.019 · Cited by 134
Strauch, E.-M., Bernard, S. M., La, D., Bohn, A. J., Lee, P. S., Anderson, C. E., Nieusma, T., Holstein, C. A., Garcia, N. K., Hooper, K. A., et al. (2017) · Nature Biotechnology · doi:10.1038/nbt.3907 · Cited by 119
Metadata
- Authors
- CARRAT, F., & FLAHAULT, A.
- Venue
- Vaccine
- Publisher
- Elsevier BV
- Published
- 2007-09-28
- Volume
- 25
- Issue
- 39-40
- Pages
- 6852-6862
- ISSN
- 0264-410X (ISSN-L)
- OpenAlex
- W2071657440
- Cited by
- 708
- References
- 65
- FWCI
- 22.19
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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