Influenza virus neuraminidase contributes to secondary bacterial pneumonia.

Peltola, Ville T.; Murti, K. Gopal; McCullers, Jonathan A.

doi:10.1086/430954

Cited by 219Influenza Virus Research StudiesRespiratory viral infections researchBacterial Infections and Vaccines

Influenza virus neuraminidase contributes to secondary bacterial pneumonia.

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Peltola, Ville T., Murti, K. Gopal, McCullers, Jonathan A.·2005·The Journal of Infectious Diseases

DOI 10.1086/430954PMC PMC2715995

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Abstract

Secondary bacterial pneumonia is a common cause of death during influenza epidemics. We hypothesized that virus-specific factors could contribute to differences in annual excess mortality. Recombinant influenza viruses with neuraminidases from representative strains from the past 50 years were created and characterized. The specific level of their neuraminidase activity correlated with their ability to support secondary bacterial pneumonia. Recombinant viruses with neuraminidases from 1957 and 1997 influenza strains had the highest level of activity, whereas a virus with the neuraminidase from a 1968 strain had the lowest level of activity. The high level of activity of the neuraminidase from the 1957 strain, compared with that of other neuraminidases, more strongly supported the adherence of Streptococcus pneumoniae and the development of secondary bacterial pneumonia in a mouse model. These data lend support to our hypothesis that the influenza virus neuraminidase contributes to secondary bacterial pneumonia and subsequent excess mortality.

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The potency of neuraminidase is correlated with the capacity of an influenza virus strain to promote pneumonia.
“Indeed, the potency of neuraminidase is correlated with the capacity of an influenza virus strain to promote pneumonia [12].”
From Streptococcus pneumoniae coinfection is correlated with the severity of H1N1 pandemic influenza (2009) · cites this paper as [12]
Specific N2 seasonal subtypes cause more severe infection than other subtypes.
“with evidence that specific N2 seasonal subtypes cause more severe infection than other subtypes”
From Bacterial and viral infections associated with influenza (2013) · cites this paper as [15]
Influenza A is the dominant strain associated with co/secondary bacterial infection.
“Influenza A is the dominant strain associated with co/secondary bacterial infection”
From Bacterial and viral infections associated with influenza (2013) · cites this paper as [15]
Influenza A is the type most commonly associated with co/secondary bacterial infection, and subtypes with NA2 traditionally result in more severe infection.
“Research shows that influenza A is the type most commonly associated with co/secondary bacterial infection and subtypes with NA2 traditionally result in more severe infection (Peltola et al., 2005).”
From Secondary bacterial infections associated with influenza pandemics (2017) · cites this paper as Peltola et al., 2005

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Authors: Peltola, V. T., Murti, K. G., & McCullers, J. A.
Affiliations: St. Jude Children's Research Hospital (US)
ORCID: Peltola, Ville T.
Murti, K. Gopal
Venue: The Journal of Infectious Diseases
Publisher: Oxford University Press (OUP)
Published: 2005-07-15
Volume: 192
Issue: 2
Pages: 249-257
ISSN: 0022-1899 (ISSN-L)
1537-6613
DOI: 10.1086/430954
PMC: PMC2715995
OpenAlex: W2110556360
Cited by: 219
References: 46
Citations by year: 2026: 4 · 2025: 4 · 2024: 5 · 2023: 8 · 2022: 9 · 2021: 8 · 2020: 10 · 2019: 6 · 2018: 9 · 2017: 12 · 2016: 6 · 2015: 10 · 2014: 15 · 2013: 11 · 2012: 7
FWCI: 10.99
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: The Journal of Infectious Diseases (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (1k08ai049178-01)
National Cancer Institute (P30CA021765)
National Institute of Allergy and Infectious Diseases (AI-54802, AI-49178, R21AI054802, R01AI066349)
Topics: Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
Life Sciences › Immunology and Microbiology › Microbiology › Bacterial Infections and Vaccines
Keywords: influenza virus, neuraminidase, secondary bacterial pneumonia, Streptococcus pneumoniae, excess mortality, recombinant influenza virus, neuraminidase activity, mouse model
MeSH terms: Allantois, Animals, Eggs, Humans, Influenza, Human, Neuraminidase, Influenza A virus, Pneumonia, Bacterial, Cell Culture Techniques, Mice

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Influenza virus neuraminidase contributes to secondary bacterial pneumonia.

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