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Human Herpesvirus 6 Latently Infects Early Bone Marrow Progenitors In Vivo
Open accessAbstract
We have studied the in vivo tropism of human herpesvirus 6 (HHV-6) for hemopoietic cells in patients with latent HHV-6 infection. Having used a variety of cell purification, molecular, cytogenetic, and immunocytochemical procedures, we report the first evidence that HHV-6 latently infects early bone marrow progenitor cells and that HHV-6 may be transmitted longitudinally to cells which differentiate along the committed pathways.
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HHV-6 causes a primary infection usually during the first two-three years of life, after which it becomes dormant predominantly inside monocytes and macrophages.
“Similar to all herpesviruses, HHV-6 causes a primary infection, usually during the first two-three years of life, after which it becomes dormant predominantly inside monocytes and macrophages [3,4,5].”
From Human Herpesvirus 6—A Rare Aetiologic Agent for CNS Infections in Immunocompetent Individuals or an Underestimation? (2024) · cites this paper as [4]
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Laboratory and Clinical Aspects of Human Herpesvirus 6 Infections
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Metadata
- Authors
- Luppi, M., Barozzi, P., Morris, C., Maiorana, A., Garber, R., Bonacorsi, G., Donelli, A., Marasca, R., Tabilio, A., & Torelli, G.
- Affiliations
- University of Modena and Reggio Emilia (IT)
- Department of Medical Sciences (RU)
- <!--label omitted: 2-->Cytogenetic and Molecular Oncology Unit, Department of Pathology, Christchurch School of Medicine, Christchurch, New Zealand2; and
- <!--label omitted: 3-->Department of Pathology,3 University of Modena, Modena, and
- Results for Development Institute (US)
- University of Perugia (IT)
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 1999-01
- Volume
- 73
- Issue
- 1
- Pages
- 754-759
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- PMC
- PMC103884
- OpenAlex
- W1803887270
- Cited by
- 139
- References
- 26
- Citations by year
- 2025: 4 · 2024: 2 · 2023: 4 · 2022: 3 · 2021: 3 · 2020: 8 · 2019: 9 · 2018: 3 · 2017: 4 · 2016: 3 · 2015: 4 · 2014: 6 · 2013: 3 · 2012: 6
- FWCI
- 2.07
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Virology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- IRIS UNIMORE (University of Modena and Reggio Emilia) (submittedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Oncology › Viral-associated cancers and disorders
- Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
- Health Sciences › Medicine › Infectious Diseases › Herpesvirus Infections and Treatments
- Keywords
- human herpesvirus 6, viral latency, bone marrow progenitor cells, hematopoietic cells, viral tropism, cell differentiation, HHV-6B
- MeSH terms
- Bone Marrow Cells, DNA, Viral, Hematopoietic Stem Cells, Herpesviridae Infections, Humans, Herpesvirus 6, Human, Polymerase Chain Reaction, Virus Latency, Antigens, CD34
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