The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Decay Kinetics of Human Immunodeficiency Virus-Specific Effector Cytotoxic T Lymphocytes after Combination Antiretroviral Therapy
Open accessAbstract
Little is known of the changes in human immunodeficiency virus type 1 (HIV-1)-specific effector cytotoxic T lymphocytes (CTL) after potent antiretroviral therapy. Using HLA/peptide tetrameric complexes, we show that after starting treatment, there are early rapid fluctuations in the HIV-1-specific CTL response which last 1 to 2 weeks. These fluctuations are followed by an exponential decay (median half-life, 45 days) of HIV-1-specific CTL which continues while viremia remains undetectable. These data have implications for the immunological control of drug-resistant virus.
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Citations
Cites
Phenotypic Analysis of Antigen-Specific T Lymphocytes
Altman, J. D., Moss, P. A. H., Goulder, P. J. R., Barouch, D. H., McHeyzer-Williams, M. G., Bell, J. I., McMichael, A. J., & Davis, M. M. (1996) · Science · doi:10.1126/science.274.5284.94 · Cited by 3,544
Self-citationImmunological memory and protective immunity: understanding their relation
Ahmed, R., & Gray, D. (1996) · Science · doi:10.1126/science.272.5258.54 · Cited by 1,775 · cited 1×
“Whether such prolonged survival is dependent on antigen persistence (1) is unknown, but it is important to compare the CTLe decay rate in individuals with late emergence of drug-resistant virus.”
Background
Cited by
HIV-specific CD8(+) T cells produce antiviral cytokines but are impaired in cytolytic function
Appay, V., Nixon, D. F., Donahoe, S. M., Gillespie, G. M. A., Dong, T., King, A., Ogg, G. S., Spiegel, H. M. L., Conlon, C., Spina, C. A., et al. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.1.63 · Cited by 871
Self-citationBoni, C., Penna, A., Ogg, G. S., Bertoletti, A., Pilli, M., Cavallo, C., Cavalli, A., Urbani, S., Boehme, R., Panebianco, R., et al. (2001) · Hepatology · doi:10.1053/jhep.2001.23045 · Cited by 339
Self-citationEarly and nonreversible decrease of CD161++/MAIT cells in HIV infection
Cosgrove, C., Ussher, J. E., Rauch, A., Gärtner, K., Kurioka, A., Hühn, M. H., Adelmann, K., Kang, Y.-H., Fergusson, J. R., Simmonds, P., et al. (2013) · Blood · doi:10.1182/blood-2012-06-436436 · Cited by 316
Annulling a dangerous liaison: vaccination strategies against AIDS and tuberculosis
Kaufmann, S. H. E., & McMichael, A. J. (2005) · Nature Medicine · doi:10.1038/nm1221 · Cited by 273
Self-citationTracking T cells with tetramers: new tales from new tools
Klenerman, P., Cerundolo, V., & Dunbar, P. R. (2002) · Nature Reviews Immunology · doi:10.1038/nri777 · Cited by 190
Metadata
- Authors
- Ogg, G. S., Jin, X., Bonhoeffer, S., Moss, P., Nowak, M. A., Monard, S., Segal, J. P., Cao, Y., Rowland-Jones, S. L., Hurley, A., Markowitz, M., Ho, D. D., McMichael, A. J., & Nixon, D. F.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 1999-01
- Volume
- 73
- Issue
- 1
- Pages
- 797-800
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W2156110652
- Cited by
- 348
- References
- 2
- FWCI
- 14.90
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Decay Kinetics of Human Immunodeficiency Virus-Specific Effector Cytotoxic T Lymphocytes after Combination Antiretroviral Therapy. https://app.cochat.ai/papers/10.1128/jvi.73.1.797-800.1999
- The paper
- Ogg, G. S., Jin, X., Bonhoeffer, S., Moss, P., Nowak, M. A., Monard, S., Segal, J. P., Cao, Y., Rowland-Jones, S. L., Hurley, A., Markowitz, M., Ho, D. D., McMichael, A. J., & Nixon, D. F. (1999). Decay Kinetics of Human Immunodeficiency Virus-Specific Effector Cytotoxic T Lymphocytes after Combination Antiretroviral Therapy. Journal of Virology. https://doi.org/10.1128/jvi.73.1.797-800.1999
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
