The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
A Mouse Model for the Evaluation of Pathogenesis and Immunity to Influenza A (H5N1) Viruses Isolated from Humans
Open accessAbstract
During 1997 in Hong Kong, 18 human cases of respiratory illness, including 6 fatalities, were caused by highly pathogenic avian influenza A (H5N1) viruses. Since H5 viruses had previously been isolated only from avian species, the outbreak raised questions about the ability of these viruses to cause severe disease and death in humans. To better understand the pathogenesis and immunity to these viruses, we have used the BALB/c mouse model. Four H5N1 viruses replicated equally well in the lungs of mice without prior adaptation but differed in lethality for mice. H5N1 viruses that were highly lethal for mice were detected in multiple organs, including the brain. This is the first demonstration of an influenza A virus that replicates systemically in a mammalian species and is neurotropic without prior adaptation. The mouse model was also used to evaluate a strategy of vaccination against the highly pathogenic avian H5N1 viruses, using an inactivated vaccine prepared from nonpathogenic A/Duck/Singapore-Q/F119-3/97 (H5N3) virus that was antigenically related to the human H5N1 viruses. Mice administered vaccine intramuscularly, with or without alum, were completely protected from lethal challenge with H5N1 virus. Protection from infection was also observed in 70% of animals administered vaccine alone and 100% of mice administered vaccine with alum. The protective effect of vaccination correlated with the level of virus-specific serum antibody. These results suggests a strategy of vaccine preparedness for rapid intervention in future influenza pandemics that uses antigenically related nonpathogenic viruses as vaccine candidates.
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Cites
A SIMPLE METHOD OF ESTIMATING FIFTY PER CENT ENDPOINTS12
REED, L. J., & MUENCH, H. (1938) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a118408 · Cited by 19,926
A simple method of estimating 50 per cent end points
Muench, H. (1938) · Medical Entomology and Zoology · Cited by 8,376
(2001) · PsycEXTRA Dataset · doi:10.1037/e548312006-001 · Cited by 5,011
Surveillance for waterborne-disease outbreaks--United States, 1993-1994.
Kramer, M. H., Herwaldt, B. L., Craun, G. F., Calderon, R. L., & Juranek, D. D. (1996) · PubMed · Cited by 2,059
Human influenza A H5N1 virus related to a highly pathogenic avian influenza virus
Claas, E. C., Osterhaus, A. D., van Beek, R., De Jong, J. C., Rimmelzwaan, G. F., Senne, D. A., Krauss, S., Shortridge, K. F., & Webster, R. G. (1998) · The Lancet · doi:10.1016/s0140-6736(97)11212-0 · Cited by 1,429
Subbarao, K., Klimov, A., Katz, J., Regnery, H., Lim, W., Hall, H., Perdue, M., Swayne, D., Bender, C., Huang, J., et al. (1998) · Science · doi:10.1126/science.279.5349.393 · Cited by 1,362
Self-citationYuen, K., Chan, P., Peiris, M., Tsang, D., Que, T., Shortridge, K., Cheung, P., To, W., Ho, E., Sung, R., et al. (1998) · The Lancet · doi:10.1016/s0140-6736(98)01182-9 · Cited by 1,052
Matrosovich, M., Zhou, N., Kawaoka, Y., & Webster, R. (1999) · Journal of Virology · doi:10.1128/jvi.73.2.1146-1155.1999 · Cited by 607
Hantavirus pulmonary syndrome. Pathogenesis of an emerging infectious disease.
Zaki, S. R., Greer, P. W., Coffield, L. M., Goldsmith, C. S., Nolte, K. B., Foucar, K. K., Feddersen, R. M., Zumwalt, R., Miller, G. L., & Khan, A. S. (1995) · Europe PMC (PubMed Central) · Cited by 603
Self-citationCharacterization of Avian H5N1 Influenza Viruses from Poultry in Hong Kong
Shortridge, K. F., Zhou, N. N., Guan, Y., Gao, P., Ito, T., Kawaoka, Y., Kodihalli, S., Krauss, S., Markwell, D., Murti, K. G., et al. (1998) · Virology · doi:10.1006/viro.1998.9488 · Cited by 589
Cited by
Influenza: lessons from past pandemics, warnings from current incidents
Horimoto, T., & Kawaoka, Y. (2005) · Nature Reviews Microbiology · doi:10.1038/nrmicro1208 · Cited by 696
Lethal H5N1 influenza viruses escape host anti-viral cytokine responses
Heui Seo, S., Hoffmann, E., & Webster, R. G. (2002) · Nature Medicine · doi:10.1038/nm757 · Cited by 654
Perrone, L. A., Plowden, J. K., García-Sastre, A., Katz, J. M., & Tumpey, T. M. (2008) · PLoS Pathogens · doi:10.1371/journal.ppat.1000115 · Cited by 623
Self-citationKumar, P. A., Hu, Y., Yamamoto, Y., Hoe, N. B., Wei, T. S., Mu, D., Sun, Y., Joo, L. S., Dagher, R., Zielonka, E. M., et al. (2011) · Cell · doi:10.1016/j.cell.2011.10.001 · Cited by 577
Pandemic Threat Posed by Avian Influenza A Viruses
Horimoto, T., & Kawaoka, Y. (2001) · Clinical Microbiology Reviews · doi:10.1128/cmr.14.1.129-149.2001 · Cited by 542
Metadata
- Authors
- Lu, X., Tumpey, T. M., Morken, T., Zaki, S. R., Cox, N. J., & Katz, J. M.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 1999-07
- Volume
- 73
- Issue
- 7
- Pages
- 5903-5911
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W2131330781
- Cited by
- 371
- References
- 24
- FWCI
- 14.29
- Type
- journal article
- Language
- en
- Open access
- green
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- Lu, X., Tumpey, T. M., Morken, T., Zaki, S. R., Cox, N. J., & Katz, J. M. (1999). A Mouse Model for the Evaluation of Pathogenesis and Immunity to Influenza A (H5N1) Viruses Isolated from Humans. Journal of Virology. https://doi.org/10.1128/jvi.73.7.5903-5911.1999
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