The DOI matches its Crossref record; 56 of the 57 references it cites were found in a registry or an index.
A Putative Cell Surface Receptor for Anemia-Inducing Feline Leukemia Virus Subgroup C Is a Member of a Transporter Superfamily
Open accessAbstract
Domestic cats infected with the horizontally transmitted feline leukemia virus subgroup A (FeLV-A) often produce mutants (termed FeLV-C) that bind to a distinct cell surface receptor and cause severe aplastic anemia in vivo and erythroblast destruction in bone marrow cultures. The major determinant for FeLV-C-induced anemia has been mapped to a small region of the surface envelope glycoprotein that is responsible for its receptor binding specificity. Thus, erythroblast destruction may directly or indirectly result from FeLV-C binding to its receptor. To address these issues, we functionally cloned a putative cell surface receptor for FeLV-C (FLVCR) by using a human T-lymphocyte cDNA library in a retroviral vector. Expression of the 2.0-kbp FLVCR cDNA in naturally resistant Swiss mouse fibroblasts and Chinese hamster ovary cells caused substantial susceptibility to FeLV-C but no change in susceptibilities to FeLV-B and other retroviruses. The predicted FLVCR protein contains 555 amino acids and 12 hydrophobic potential membrane-spanning sequences. Database searches indicated that FLVCR is a member of the major-facilitator superfamily of transporters and implied that it may transport an organic anion. RNA blot analyses showed that FLVCR mRNA is expressed in multiple hematopoietic lineages rather than specifically in erythroblasts. These results suggest that the targeted destruction of erythroblasts by FeLV-C may derive from their greater sensitivity to this virus rather than from a preferential susceptibility to infection.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“These heme complexes are then shuttled out of the mitochondria to the cytosol by the Feline Leukemia Virus Subgroup Receptor 1 (FLVCR1) (Tailor et al., 1999) where hemoglobin in erythrocytes, or other proteins known as hemoproteins, incorporate the heme complex to confer functionality;”
From The Role of Iron Regulation in Immunometabolism and Immune-Related Disease (2019) · cites this paper as Tailor et al., 1999
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs
Altschul, S. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.17.3389 · Cited by 73,302
A simple method for displaying the hydropathic character of a protein
Kyte, J., & Doolittle, R. F. (1982) · Journal of Molecular Biology · doi:10.1016/0022-2836(82)90515-0 · Cited by 22,927
Pao, S. S., Paulsen, I. T., & Saier, M. H. (1998) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.62.1.1-34.1998 · Cited by 2,297
Morgenstern, J. P., & Land, H. (1990) · Nucleic Acids Research · doi:10.1093/nar/18.12.3587 · Cited by 2,099
Synthesis and Processing of Asparagine-Linked Oligosaccharides
Hubbard, S. C., & Ivatt, R. J. (1981) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.50.070181.003011 · Cited by 1,382
Change in Coreceptor Use Correlates with Disease Progression in HIV-1–Infected Individuals
Connor, R. I., Sheridan, K. E., Ceradini, D. J., Choe, S. S., & Landau, N. R. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.4.621 · Cited by 1,356
Expression cloning of new receptors used by simian and human immunodeficiency viruses
Deng, H., Unutmaz, D., KewalRamani, V. N., & Littman, D. R. (1997) · Nature · doi:10.1038/40894 · Cited by 684
High-titer packaging cells producing recombinant retroviruses resistant to human serum
Cosset, F., Takeuchi, Y., Battini, J., Weiss, R. A., & Collins, M. K. (1995) · Journal of Virology · doi:10.1128/jvi.69.12.7430-7436.1995 · Cited by 661
Kavanaugh, M. P., Miller, D. G., Zhang, W., Law, W., Kozak, S. L., Kabat, D., & Miller, A. D. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.15.7071 · Cited by 585
Self-citationTransport of cationic amino acids by the mouse ecotropic retrovirus receptor
Kim, J. W., Closs, E. I., Albritton, L. M., & Cunningham, J. M. (1991) · Nature · doi:10.1038/352725a0 · Cited by 549
Cited by
Sorted by citations
Items 101–134 of 134
Clark, K. F. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-801573-5.00026-7 · Cited by 8
Russo, V., Roperto, F. P., Taulescu, M. A., Falco, F. D., Urraro, C., Corrado, F., Munday, J. S., Cătoi, C., & Roperto, S. (2019) · Veterinary Microbiology · doi:10.1016/j.vetmic.2018.12.024 · Cited by 9
FeLIX is a restriction factor for mammalian retrovirus infection
Pramono, D., Takeuchi, D., Katsuki, M., AbuEed, L., Abdillah, D. A., Kimura, T., Kawasaki, J., Miyake, A., & Nishigaki, K. (2024) · Journal of Virology · doi:10.1128/jvi.01771-23 · Cited by 7
Bertino, F., Mukherjee, D., Bonora, M., Bagowski, C. P., Nardelli, J., Metani, L., Venturini, D. I. Z., Chianese, D., Santander, N. G., Salaroglio, I. C., et al. (2024) · Cell Reports Medicine · doi:10.1016/j.xcrm.2024.101647 · Cited by 7
An All-Feline Retroviral Packaging System for Transduction of Human Cells
Doty, R. T., Sabo, K. M., Chen, J., Miller, A. D., & Abkowitz, J. L. (2010) · Human Gene Therapy · doi:10.1089/hum.2010.032 · Cited by 8
What role do endogenous retroviruses play in domestic cats infected with feline leukaemia virus?
Valdés, M. C. C., Bolio‐González, M. E., Acevedo-Jiménez, G. E., & Álvarez, H. R. (2022) · New Zealand Veterinary Journal · doi:10.1080/00480169.2022.2131648 · Cited by 7
New Insights into the Pathophysiology of Acquired Cytopenias
Young, N. S., Abkowitz, J. L., & Luzzatto, L. (2000) · Hematology · doi:10.1182/asheducation.v2000.1.18.20000018 · Cited by 6
Chemical Digestion, Absorption, and Transport
Welcome, M. O. (2018) · Springer eBooks · doi:10.1007/978-3-319-91056-7_12 · Cited by 6
Retrovirus Receptor Interactions and Entry
Albritton, L. M. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811185-7.00001-7 · Cited by 6
Jarrett, O., & Neil, J. C. (2012) · Encyclopedia of Life Sciences · doi:10.1002/9780470015902.a0001021.pub2 · Cited by 5
Wavy changes in the whiskers of domestic cats are correlated with feline leukemia virus infection
Morishita, M., Sunden, Y., Horiguchi, M., Sakoya, H., Yokogawa, M., Ino, H., Satoshi, U. N. E., KAWATA, M., Hosoido, T., & MORITA, T. (2023) · BMC Veterinary Research · doi:10.1186/s12917-023-03610-7 · Cited by 4
Receptors for animal retroviruses
Miyazawa, T. (2009) · Uirusu · doi:10.2222/jsv.59.223 · Cited by 4
Boenzli, E., Robert-Tissot, C., Sabatino, G., Cattori, V., Meli, M. L., Gutte, B., Rovero, P., Flynn, N., Hofmann‐Lehmann, R., & Lutz, H. (2011) · Antiviral Therapy · doi:10.3851/imp1850 · Cited by 4
Hussain, N., Thickett, K. R., Na, H., Leung, C. Y., & Tailor, C. S. (2011) · Journal of Virology · doi:10.1128/jvi.00822-11 · Cited by 3
Self-citationRelationship Between Iron and Erythropoiesis
Sposi, N. M. (2012) · Contact-less Assessment of In-vivo Body Signals Using Microwave Doppler Radar (InTech) · doi:10.5772/33246 · Cited by 2
Rampaul, M., Argenta, N., Bojko, J., Fazelan, Z., & Clark, K. F. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-91169-6.00016-9 · Cited by 2
Valdivieso-Torres, L., Sarangi, A., Whidby, J., Marcotrigiano, J., & Roth, M. J. (2015) · Journal of Virology · doi:10.1128/jvi.02544-15 · Cited by 2
Expression and purification of the heme exporter FLVCR1a
Chiabrando, D., Scietti, L., Prajica, A. G., Bertino, F., Tolosano, E., & Magnani, F. (2020) · Protein Expression and Purification · doi:10.1016/j.pep.2020.105637 · Cited by 2
Jarrett, O. (2001) · Encyclopedia of Life Sciences · doi:10.1038/npg.els.0001021 · Cited by 2
Walter‐Nuno, A. B., Taracena, M. L., Oliveira, M., de Oliveira, M. F., de Oliveira, P. L., & Paiva‐Silva, G. O. (2024) · The FASEB Journal · doi:10.1096/fj.202301671rr · Cited by 1
Vasconcelos, A., Júnior, R., & Horizonte-MG, B. (2006) · Cited by 1
Cell entry and exit of porcine endogenous retrovirus A: receptors and release inhibitor
Mattiuzzo, G. (2010) · UCL Discovery (University College London) · Cited by 1
The role of haem transport and iron chelation in oesophageal cancer
Ford, S. (2013) · University of Birmingham Institutional Research Archive (University of Birmingham)
Coronado, G. S., & Swenson, C. L. (2004) · American Journal of Veterinary Research · doi:10.2460/ajvr.2004.65.436
Aidoo, F. A. (2012) · TSpace (University of Toronto)
Meta-engineering in drug design: A roadmap to implement a novel liposome-based testbed
Boenzli, E., Hadorn, M., & Hotz, P. E. (2010) · University of Southern Denmark Research Portal (University of Southern Denmark)
การตรวจไวรัสมะเร็งเม็ดเลือดขาวในแมวที่รวดเร็วด้วยวิธี recombinase polymerase amplification (RPA)
ลาชโรจน์, ส. (2019) · Chula Digiverse · doi:10.58837/chula.the.2019.1159
Hsu, T. Y., Talley, M. J., Yang, P., Geiselhoeringer, A., Yang, C. L.-H., Gorla, A., Rahman, M. J., Silva, L., Chen, D., & Yang, B. (2024) · Biotechnology Progress · doi:10.1002/btpr.3485
Die FeLV-Infektion bei der Katze – ein Update
Stuhlmüller, J., & Mangelsdorf, S. (2025) · kleintier konkret · doi:10.1055/a-2539-0751
Imputabilité des rétrovirus dans les pathologies présumées post infectieuses de l'enfant
Jeziorski, É. (2011) · theses.fr (ABES) · doi:10.70675/1b213352z9c54z4f71z8b0fz5e2b42e639e5
FLVCR1-related diseases: from clinical heterogeneity to mechanistic insights
Venturini, D. I. Z., & Chiabrando, D. (2026) · Brain Communications · doi:10.1093/braincomms/fcag165
UNDERSTANDING THE ROLE OF RIBOSOMAL PROTEINS AND FLVCR1 ABERRANT SPLICING IN DIAMOND BLACKFAN ANEMIA
Fernandes, A. B., & Tailor, C. S. (2012) · TSpace (University of Toronto)
Self-citation
Metadata
- Authors
- Tailor, C. S., Willett, B. J., & Kabat, D.
- Affiliations
- Oregon Health & Science University (US)
- University of Glasgow (GB)
- ORCID
- Willett, Brian J.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 1999-08
- Volume
- 73
- Issue
- 8
- Pages
- 6500-6505
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- PMC
- PMC112732
- OpenAlex
- W2136280576
- Cited by
- 137
- References
- 57
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 10 · 2023: 4 · 2022: 3 · 2021: 1 · 2020: 2 · 2019: 5 · 2018: 6 · 2017: 2 · 2016: 4 · 2015: 6 · 2014: 2 · 2013: 7 · 2012: 11
- FWCI
- 1.83
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Virology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (acceptedVersion)
- Funders
- National Institutes of Health (5r01ca025810-23)
- National Cancer Institute (CA 25810)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and Retrovirus Studies
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Keywords
- cell surface receptors, major facilitator superfamily, organic anion transport, receptor specificity, envelope glycoprotein, aplastic anemia, hematopoietic lineage, cats
- MeSH terms
- Amino Acid Sequence, Anemia, Aplastic, Animals, Base Sequence, Carrier Proteins, Cats, Leukemia Virus, Feline, Cricetinae, Humans, Molecular Sequence Data, Receptors, Virus, Tissue Distribution, Gene Expression, CHO Cells, 3T3 Cells, Caenorhabditis elegans, Sequence Homology, Amino Acid, DNA, Complementary, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
