Cited by 137T-cell and Retrovirus StudiesHIV Research and TreatmentDrug Transport and Resistance Mechanisms

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A Putative Cell Surface Receptor for Anemia-Inducing Feline Leukemia Virus Subgroup C Is a Member of a Transporter Superfamily

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Tailor, Chetankumar S., Willett, Brian J., Kabat, David·1999·Journal of Virology

DOI 10.1128/jvi.73.8.6500-6505.1999PMC PMC112732

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Abstract

Domestic cats infected with the horizontally transmitted feline leukemia virus subgroup A (FeLV-A) often produce mutants (termed FeLV-C) that bind to a distinct cell surface receptor and cause severe aplastic anemia in vivo and erythroblast destruction in bone marrow cultures. The major determinant for FeLV-C-induced anemia has been mapped to a small region of the surface envelope glycoprotein that is responsible for its receptor binding specificity. Thus, erythroblast destruction may directly or indirectly result from FeLV-C binding to its receptor. To address these issues, we functionally cloned a putative cell surface receptor for FeLV-C (FLVCR) by using a human T-lymphocyte cDNA library in a retroviral vector. Expression of the 2.0-kbp FLVCR cDNA in naturally resistant Swiss mouse fibroblasts and Chinese hamster ovary cells caused substantial susceptibility to FeLV-C but no change in susceptibilities to FeLV-B and other retroviruses. The predicted FLVCR protein contains 555 amino acids and 12 hydrophobic potential membrane-spanning sequences. Database searches indicated that FLVCR is a member of the major-facilitator superfamily of transporters and implied that it may transport an organic anion. RNA blot analyses showed that FLVCR mRNA is expressed in multiple hematopoietic lineages rather than specifically in erythroblasts. These results suggest that the targeted destruction of erythroblasts by FeLV-C may derive from their greater sensitivity to this virus rather than from a preferential susceptibility to infection.

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Authors: Tailor, C. S., Willett, B. J., & Kabat, D.
Affiliations: Oregon Health & Science University (US)
University of Glasgow (GB)
ORCID: Willett, Brian J.
Venue: Journal of Virology
Publisher: American Society for Microbiology
Published: 1999-08
Volume: 73
Issue: 8
Pages: 6500-6505
ISSN: 0022-538X (ISSN-L)
1098-5514
DOI: 10.1128/jvi.73.8.6500-6505.1999
PMC: PMC112732
OpenAlex: W2136280576
Cited by: 137
References: 57
Citations by year: 2026: 1 · 2025: 2 · 2024: 10 · 2023: 4 · 2022: 3 · 2021: 1 · 2020: 2 · 2019: 5 · 2018: 6 · 2017: 2 · 2016: 4 · 2015: 6 · 2014: 2 · 2013: 7 · 2012: 11
FWCI: 1.83
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Journal of Virology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (acceptedVersion)
Funders: National Institutes of Health (5r01ca025810-23)
National Cancer Institute (CA 25810)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and Retrovirus Studies
Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
Keywords: cell surface receptors, major facilitator superfamily, organic anion transport, receptor specificity, envelope glycoprotein, aplastic anemia, hematopoietic lineage, cats
MeSH terms: Amino Acid Sequence, Anemia, Aplastic, Animals, Base Sequence, Carrier Proteins, Cats, Leukemia Virus, Feline, Cricetinae, Humans, Molecular Sequence Data, Receptors, Virus, Tissue Distribution, Gene Expression, CHO Cells, 3T3 Cells, Caenorhabditis elegans, Sequence Homology, Amino Acid, DNA, Complementary, Mice

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A Putative Cell Surface Receptor for Anemia-Inducing Feline Leukemia Virus Subgroup C Is a Member of a Transporter Superfamily

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