The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
A Significant Number of Human Immunodeficiency Virus Epitope-Specific Cytotoxic T Lymphocytes Detected by Tetramer Binding Do Not Produce Gamma Interferon
Open accessAbstract
Despite the seemingly important role of cytotoxic T-lymphocyte (CTL) responses in human immunodeficiency virus (HIV) disease pathogenesis, their measurement has relied on a variety of different techniques. We utilized three separate methodologies for the detection of CTLs in a cohort of HIV-infected individuals who were also human leukocyte antigen A2 (HLA-A2) positive. Among the different CTL assays, a correlation was seen only when the Gag epitope-specific HLA A*0201-restricted tetramer assay was compared with the ELISPOT assay performed after stimulation with the Gag epitope; however, this correlation was of borderline statistical significance. On average, the tetramer reagent detected a 10-fold-higher number of cells than were seen to produce gamma interferon by the ELISPOT assay. The implications of this CTL assay comparison and the possibility of phenotypic differences in HIV-specific CD8+T lymphocytes are discussed.
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Cites
Phenotypic Analysis of Antigen-Specific T Lymphocytes
Altman, J. D., Moss, P. A. H., Goulder, P. J. R., Barouch, D. H., McHeyzer-Williams, M. G., Bell, J. I., McMichael, A. J., & Davis, M. M. (1996) · Science · doi:10.1126/science.274.5284.94 · Cited by 3,544 · cited 2×
“Three-color analysis for flow cytometry (1, 29, 32, 33) used the SL9 tetramer, antihuman CD8 (Becton Dickinson, San Diego, Calif.”
MethodViral Immune Evasion Due to Persistence of Activated T Cells Without Effector Function
Zajac, A. J., Blattman, J. N., Murali-Krishna, K., Sourdive, D. J. D., Suresh, M., Altman, J. D., & Ahmed, R. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.12.2205 · Cited by 1,978
Cited by
PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression
Day, C. L., Kaufmann, D. E., Kiepiela, P., Brown, J. A., Moodley, E. S., Reddy, S., Mackey, E. W., Miller, J. D., Leslie, A. J., DePierres, C., et al. (2006) · Nature · doi:10.1038/nature05115 · Cited by 2,680
Ablation of CD8 and CD4 T Cell Responses by High Viral Loads
Fuller, M. J., & Zajac, A. J. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.1.477 · Cited by 276
Metadata
- Authors
- Goepfert, P. A., Bansal, A., Edwards, B. H., Ritter, G. D., Tellez, I., McPherson, S. A., Sabbaj, S., & Mulligan, M. J.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 2000-11
- Volume
- 74
- Issue
- 21
- Pages
- 10249-10255
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W2114098868
- Cited by
- 197
- References
- 2
- FWCI
- 6.61
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: A Significant Number of Human Immunodeficiency Virus Epitope-Specific Cytotoxic T Lymphocytes Detected by Tetramer Binding Do Not Produce Gamma Interferon. https://app.cochat.ai/papers/10.1128/jvi.74.21.10249-10255.2000
- The paper
- Goepfert, P. A., Bansal, A., Edwards, B. H., Ritter, G. D., Tellez, I., McPherson, S. A., Sabbaj, S., & Mulligan, M. J. (2000). A Significant Number of Human Immunodeficiency Virus Epitope-Specific Cytotoxic T Lymphocytes Detected by Tetramer Binding Do Not Produce Gamma Interferon. Journal of Virology. https://doi.org/10.1128/jvi.74.21.10249-10255.2000
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