The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Expression of Mouse Interleukin-4 by a Recombinant Ectromelia Virus Suppresses Cytolytic Lymphocyte Responses and Overcomes Genetic Resistance to Mousepox
Open accessAbstract
Genetic resistance to clinical mousepox (ectromelia virus) varies among inbred laboratory mice and is characterized by an effective natural killer (NK) response and the early onset of a strong CD8+cytotoxic T-lymphocyte (CTL) response in resistant mice. We have investigated the influence of virus-expressed mouse interleukin-4 (IL-4) on the cell-mediated response during infection. It was observed that expression of IL-4 by a thymidine kinase-positive ectromelia virus suppressed cytolytic responses of NK and CTL and the expression of gamma interferon by the latter. Genetically resistant mice infected with the IL-4-expressing virus developed symptoms of acute mousepox accompanied by high mortality, similar to the disease seen when genetically sensitive mice are infected with the virulent Moscow strain. Strikingly, infection of recently immunized genetically resistant mice with the virus expressing IL-4 also resulted in significant mortality due to fulminant mousepox. These data therefore suggest that virus-encoded IL-4 not only suppresses primary antiviral cell-mediated immune responses but also can inhibit the expression of immune memory responses.
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Citations
Cites
Cytokines and immunity to viral infections
Ramshaw, I. A., Ramsay, A. J., Karupiah, G., Rolph, M. S., Mahalingam, S., & Ruby, J. C. (1997) · Immunological Reviews · doi:10.1111/j.1600-065x.1997.tb01011.x · Cited by 257
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Cited by
McFadden, G. (2005) · Nature Reviews Microbiology · doi:10.1038/nrmicro1099 · Cited by 523
(2002) · Oxford University Research Archive (ORA) (University of Oxford) · Cited by 421
Vaccinia virus immune evasion: mechanisms, virulence and immunogenicity
Smith, G. L., Benfield, C. T. O., Maluquer de Motes, C., Mazzon, M., Ember, S. W. J., Ferguson, B. J., & Sumner, R. P. (2013) · Journal of General Virology · doi:10.1099/vir.0.055921-0 · Cited by 364
Cytokine Milieu of Atopic Dermatitis Skin Subverts the Innate Immune Response to Vaccinia Virus
Howell, M. D., Gallo, R. L., Boguniewicz, M., Jones, J. F., Wong, C., Streib, J. E., & Leung, D. Y. M. (2006) · Immunity · doi:10.1016/j.immuni.2006.02.006 · Cited by 335
Ada, G. (2001) · New England Journal of Medicine · doi:10.1056/nejmra011223 · Cited by 291
Metadata
- Authors
- Jackson, R. J., Ramsay, A. J., Christensen, C. D., Beaton, S., Hall, D. F., & Ramshaw, I. A.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 2001-02
- Volume
- 75
- Issue
- 3
- Pages
- 1205-1210
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W2155996896
- Cited by
- 565
- References
- 1
- FWCI
- 13.63
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Expression of Mouse Interleukin-4 by a Recombinant Ectromelia Virus Suppresses Cytolytic Lymphocyte Responses and Overcomes Genetic Resistance to Mousepox. https://app.cochat.ai/papers/10.1128/jvi.75.3.1205-1210.2001
- The paper
- Jackson, R. J., Ramsay, A. J., Christensen, C. D., Beaton, S., Hall, D. F., & Ramshaw, I. A. (2001). Expression of Mouse Interleukin-4 by a Recombinant Ectromelia Virus Suppresses Cytolytic Lymphocyte Responses and Overcomes Genetic Resistance to Mousepox. Journal of Virology. https://doi.org/10.1128/jvi.75.3.1205-1210.2001
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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