The DOI matches its Crossref record; 212 of the 212 references it cites were found in a registry or an index.
Vaccinia virus immune evasion: mechanisms, virulence and immunogenicity
Open accessAbstract
Virus infection of mammalian cells is sensed by pattern recognition receptors and leads to an innate immune response that restricts virus replication and induces adaptive immunity. In response, viruses have evolved many countermeasures that enable them to replicate and be transmitted to new hosts, despite the host innate immune response. Poxviruses, such as vaccinia virus (VACV), have large DNA genomes and encode many proteins that are dedicated to host immune evasion. Some of these proteins are secreted from the infected cell, where they bind and neutralize complement factors, interferons, cytokines and chemokines. Other VACV proteins function inside cells to inhibit apoptosis or signalling pathways that lead to the production of interferons and pro-inflammatory cytokines and chemokines. In this review, these VACV immunomodulatory proteins are described and the potential to create more immunogenic VACV strains by manipulation of the gene encoding these proteins is discussed.
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Vaccinia virus-mediated cancer immunotherapy: cancer vaccines and oncolytics
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Minnaert, A.-K., Vanluchene, H., Verbeke, R., Lentacker, I., De Smedt, S. C., Raemdonck, K., Sanders, N. N., & Remaut, K. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.113900 · Cited by 157
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Metadata
- Authors
- Smith, G. L., Benfield, C. T. O., Maluquer de Motes, C., Mazzon, M., Ember, S. W. J., Ferguson, B. J., & Sumner, R. P.
- Venue
- Journal of General Virology
- Publisher
- Microbiology Society
- Published
- 2013-11-01
- Volume
- 94
- Issue
- 11
- Pages
- 2367-2392
- ISSN
- 0022-1317 (ISSN-L)
- 1465-2099
- OpenAlex
- W1989893709
- Cited by
- 364
- References
- 212
- FWCI
- 12.68
- Type
- journal article
- Language
- en
- Open access
- green
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- Smith, G. L., Benfield, C. T. O., Maluquer de Motes, C., Mazzon, M., Ember, S. W. J., Ferguson, B. J., & Sumner, R. P. (2013). Vaccinia virus immune evasion: mechanisms, virulence and immunogenicity. Journal of General Virology. https://doi.org/10.1099/vir.0.055921-0
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