The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Adenovirus Type 11 Uses CD46 as a Cellular Receptor
Open accessAbstract
The 51 human adenovirus serotypes are divided into six species (A to F). Many adenoviruses use the coxsackie-adenovirus receptor (CAR) for attachment to host cells in vitro. Species B adenoviruses do not compete with CAR-binding serotypes for binding to host cells, and it has been suggested that species B adenoviruses use a receptor other than CAR. Species B adenoviruses mainly cause disease in the respiratory tract, the eyes, and in the urinary tract. Here we demonstrate that adenovirus type 11 (Ad11; of species B) binds to Chinese hamster ovary (CHO) cells transfected with CD46 (membrane cofactor protein)-cDNA at least 10 times more strongly than to CHO cells transfected with cDNAs encoding CAR or CD55 (decay accelerating factor). Nonpermissive CHO cells were rendered permissive to Ad11 infection upon transfection with CD46-cDNA. Soluble Ad11 fiber knob but not Ad7 or Ad5 knob inhibited binding of Ad11 virions to CD46-transfected cells, and anti-CD46 antibodies inhibited both binding of and infection by Ad11. From these results we conclude that CD46 is a cellular receptor for Ad11.
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Cites
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Adenovirus Protein VI Mediates Membrane Disruption following Capsid Disassembly
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Russell, W. C. (2009) · Journal of General Virology · doi:10.1099/vir.0.003087-0 · Cited by 461
The Human Membrane Cofactor CD46 Is a Receptor for Species B Adenovirus Serotype 3
Sirena, D., Lilienfeld, B., Eisenhut, M., Kälin, S., Boucke, K., Beerli, R. R., Vogt, L., Ruedl, C., Bachmann, M. F., Greber, U. F., et al. (2004) · Journal of Virology · doi:10.1128/jvi.78.9.4454-4462.2004 · Cited by 288
Zhang, Y., & Bergelson, J. M. (2005) · Journal of Virology · doi:10.1128/jvi.79.19.12125-12131.2005 · Cited by 258
Current Advances and Future Challenges in Adenoviral Vector Biology and Targeting
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Metadata
- Authors
- Segerman, A., Atkinson, J. P., Marttila, M., Dennerquist, V., Wadell, G., & Arnberg, N.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 2003-09
- Volume
- 77
- Issue
- 17
- Pages
- 9183-9191
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W2153155292
- Cited by
- 358
- References
- 47
- FWCI
- 22.10
- Type
- journal article
- Language
- en
- Open access
- green
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