Current Advances and Future Challenges in Adenoviral Vector Biology and Targeting

Characteristics of a human cell line transformed by DNA from human adenovirus type 5

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Geometric Control of Cell Life and Death

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Rab proteins as membrane organizers

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Isolation of a Common Receptor for Coxsackie B Viruses and Adenoviruses 2 and 5

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Integrins αvβ3 and αvβ5 promote adenovirus internalization but not virus attachment

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Organ targeting In vivo using phage display peptide libraries

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Isolation of a Cytopathogenic Agent from Human Adenoids Undergoing Spontaneous Degeneration in Tissue Culture

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Gene Therapy Death Prompts Review of Adenovirus Vector

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The three-dimensional structure of foot-and-mouth disease virus at 2.9 Å resolution

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Stepwise dismantling of adenovirus 2 during entry into cells

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CD46 is a cellular receptor for group B adenoviruses

Gaggar, A., Shayakhmetov, D. M., & Lieber, A. (2003) · Nature Medicine · doi:10.1038/nm952 · Cited by 793 · see citing works

An Adenovirus Vector with Genetically Modified Fibers Demonstrates Expanded Tropism via Utilization of a Coxsackievirus and Adenovirus Receptor-Independent Cell Entry Mechanism

Dmitriev, I. P., Krasnykh, V. N., Miller, C. R., Wang, M., Kashentseva, E. A., Mikheeva, G., Belousova, N., & Curiel, D. T. (1998) · Journal of Virology · doi:10.1128/jvi.72.12.9706-9713.1998 · Cited by 768 · see citing works

How Viruses Enter Animal Cells

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The coxsackievirus and adenovirus receptor is a transmembrane component of the tight junction

Cohen, C. J., Shieh, J. T. C., Pickles, R. J., Okegawa, T., Hsieh, J., & Bergelson, J. M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.261452898 · Cited by 702 · see citing works

Genetic content and evolution of adenoviruses

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Genome-wide analysis of human kinases in clathrin- and caveolae/raft-mediated endocytosis

Pelkmans, L., Fava, E., Grabner, H., Hannus, M., Habermann, B. H., Krausz, E., & Zerial, M. (2005) · Nature · doi:10.1038/nature03571 · Cited by 607 · see citing works

The viruses and their replication

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Adenovirus triggers macropinocytosis and endosomal leakage together with its clathrin-mediated uptake

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Adenovirus Protein VI Mediates Membrane Disruption following Capsid Disassembly

Wiethoff, C. M., Wodrich, H., Gerace, L., & Nemerow, G. R. (2005) · Journal of Virology · doi:10.1128/jvi.79.4.1992-2000.2005 · Cited by 466 · see citing works

Structural Analysis of the Mechanism of Adenovirus Binding to Its Human Cellular Receptor, CAR

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Molecular basis of the inflammatory response to adenovirus vectors

Liu, Q., & Muruve, D. A. (2003) · Gene Therapy · doi:10.1038/sj.gt.3302036 · Cited by 432 · see citing works

Adenovirus Binding to Blood Factors Results in Liver Cell Infection and Hepatotoxicity

Shayakhmetov, D. M., Gaggar, A., Ni, S., Li, Z.-Y., & Lieber, A. (2005) · Journal of Virology · doi:10.1128/jvi.79.12.7478-7491.2005 · Cited by 429 · see citing works

Adenovirus endocytosis

Meier, O. C., & Greber, U. F. (2004) · The Journal of Gene Medicine · doi:10.1002/jgm.553 · Cited by 415 · see citing works

Blood clearance rates of adenovirus type 5 in mice

Alemany, R., Suzuki, K., & Curiel, D. T. (2000) · Journal of General Virology · doi:10.1099/0022-1317-81-11-2605 · Cited by 414 · see citing works

The Innate Immune Response to Adenovirus Vectors

Muruve, D. A. (2004) · Human Gene Therapy · doi:10.1089/hum.2004.15.1157 · Cited by 408 · see citing works

Site-Specific Genomic Integration in Mammalian Cells Mediated by Phage φC31 Integrase

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Identification of a Conserved Receptor-Binding Site on the Fiber Proteins of CAR-Recognizing Adenoviridae

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Adenovirus Fiber Disrupts CAR-Mediated Intercellular Adhesion Allowing Virus Escape

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Difference imaging of adenovirus: bridging the resolution gap between X‐ray crystallography and electron microscopy.

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Acute Cytokine Response to Systemic Adenoviral Vectors in Mice Is Mediated by Dendritic Cells and Macrophages

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Innate Immune Response to Adenoviral Vectors Is Mediated by both Toll-Like Receptor-Dependent and -Independent Pathways

Zhu, J., Huang, X., & Yang, Y. (2007) · Journal of Virology · doi:10.1128/jvi.02192-06 · Cited by 370 · see citing works

Adenovirus Type 11 Uses CD46 as a Cellular Receptor

Segerman, A., Atkinson, J. P., Marttila, M., Dennerquist, V., Wadell, G., & Arnberg, N. (2003) · Journal of Virology · doi:10.1128/jvi.77.17.9183-9191.2003 · Cited by 358 · see citing works

Toward cell–targeting gene therapy vectors: Selection of cell–binding peptides from random peptide–presenting phage libraries

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Import of adenovirus DNA involves the nuclear pore complex receptor CAN/Nup214 and histone H1

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A triple β-spiral in the adenovirus fibre shaft reveals a new structural motif for a fibrous protein

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Adenovirus targeted to heparan-containing receptors increases its gene delivery efficiency to multiple cell types

Wickham, T. J., Roelvink, P. W., Brough, D. E., & Kovesdi, I. (1996) · Nature Biotechnology · doi:10.1038/nbt1196-1570 · Cited by 325 · see citing works

Sequestration of Adenoviral Vector by Kupffer Cells Leads to a Nonlinear Dose Response of Transduction in Liver

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Antigens and structure of the adenovirus

Valentine, R. C., & Pereira, H. G. (1965) · Journal of Molecular Biology · doi:10.1016/s0022-2836(65)80076-6 · Cited by 316 · see citing works

Polymer-coated adenovirus permits efficient retargeting and evades neutralising antibodies

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Characterization of an Adenovirus Vector Containing a Heterologous Peptide Epitope in the HI Loop of the Fiber Knob

Krasnykh, V. N., Dmitriev, I. P., Mikheeva, G., Miller, C. R., Belousova, N., & Curiel, D. T. (1998) · Journal of Virology · doi:10.1128/jvi.72.3.1844-1852.1998 · Cited by 314 · see citing works

In Situ Gene Therapy for Adenocarcinoma of the Prostate: A Phase I Clinical Trial

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Molecular composition of the adenovirus type 2 virion

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Multiple vitamin K-dependent coagulation zymogens promote adenovirus-mediated gene delivery to hepatocytes

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Adenoviral vectors for gene transfer and therapy

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CAR-binding ablation does not change biodistribution and toxicity of adenoviral vectors

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Heparan Sulfate Glycosaminoglycans Are Receptors Sufficient To Mediate the Initial Binding of Adenovirus Types 2 and 5

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The Human Membrane Cofactor CD46 Is a Receptor for Species B Adenovirus Serotype 3

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Targeted adenovirus gene transfer to endothelial and smooth muscle cells by using bispecific antibodies

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Image reconstruction reveals the complex molecular organization of adenovirus

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Evolution of Cell Recognition by Viruses

Baranowski, É., Ruiz-Jarabo, C. M., & Domingo, E. (2001) · Science · doi:10.1126/science.1058613 · Cited by 279 · see citing works

Crystal structure of reovirus attachment protein σ1 reveals evolutionary relationship to adenovirus fiber

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Crystal structure of the receptor-binding domain of adenovirus type 5 fiberprotein at 1.7 Å resolution

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Sleeping beauty transposition: biology and applications for molecular therapy.

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Adenovirus Endocytosis via α v Integrins Requires Phosphoinositide-3-OH Kinase

Li, E., Stupack, D. G., Klemke, R. L., Cheresh, D. A., & Nemerow, G. R. (1998) · Journal of Virology · doi:10.1128/jvi.72.3.2055-2061.1998 · Cited by 250 · see citing works

Adenovirus Endocytosis Requires Actin Cytoskeleton Reorganization Mediated by Rho Family GTPases

Li, E., Stupack, D. G., Bokoch, G., & Nemerow, G. R. (1998) · Journal of Virology · doi:10.1128/jvi.72.11.8806-8812.1998 · Cited by 249 · see citing works

Structural and Phylogenetic Analysis of Adenovirus Hexons by Use of High-Resolution X-Ray Crystallographic, Molecular Modeling, and Sequence-Based Methods

Rux, J. J., Kuser, P. R., & Burnett, R. M. (2003) · Journal of Virology · doi:10.1128/jvi.77.17.9553-9566.2003 · Cited by 238 · see citing works

The icosahedral form of an adenovirus

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The coxsackievirus-adenovirus receptor protein as a cell adhesion molecule in the developing mouse brain

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The Structure of the Human Adenovirus 2 Penton

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Evaluation of polyethylene glycol modification of first-generation and helper-dependent adenoviral vectors to reduce innate immune responses

Mok, H. S., Palmer, D. J., Ng, P., & Barry, M. A. (2004) · Molecular Therapy · doi:10.1016/j.ymthe.2004.09.015 · Cited by 232 · see citing works

Biology of Adenovirus and Its Use as a Vector for Gene Therapy

McConnell, M. J., & Imperiale, M. J. (2004) · Human Gene Therapy · doi:10.1089/hum.2004.15.1022 · Cited by 230 · see citing works

Adenovirus-induced thrombocytopenia: the role of von Willebrand factor and P-selectin in mediating accelerated platelet clearance

Othman, M., Labelle, A., Mazzetti, I., Elbatarny, H. S., & Lillicrap, D. (2006) · Blood · doi:10.1182/blood-2006-06-032524 · Cited by 220 · see citing works

Adenovirus Serotype 5 Fiber Shaft Influences In Vivo Gene Transfer in Mice

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Genetic Targeting of an Adenovirus Vector via Replacement of the Fiber Protein with the Phage T4 Fibritin

Krasnykh, V. N., Belousova, N., Korokhov, N., Mikheeva, G., & Curiel, D. T. (2001) · Journal of Virology · doi:10.1128/jvi.75.9.4176-4183.2001 · Cited by 206 · see citing works

Integrin αvβ1 Is an Adenovirus Coreceptor

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Helper-Dependent Adenovirus Vectors Elicit Intact Innate but Attenuated Adaptive Host Immune Responses In Vivo

Muruve, D. A., Cotter, M. J., Zaiss, A. K., White, L. R., Liu, Q., Chan, T., Clark, S. A., Ross, P. J., Meulenbroek, R. A., Mælandsmo, G. M., et al. (2004) · Journal of Virology · doi:10.1128/jvi.78.11.5966-5972.2004 · Cited by 201 · see citing works

Dependence of Adenovirus Infectivity on Length of the Fiber Shaft Domain

Shayakhmetov, D. M., & Lieber, A. (2000) · Journal of Virology · doi:10.1128/jvi.74.22.10274-10286.2000 · Cited by 197 · see citing works

Helper-Dependent Adenoviral Vectors for Gene Therapy

Palmer, D. J., & Ng, P. (2005) · Human Gene Therapy · doi:10.1089/hum.2005.16.1 · Cited by 196 · see citing works

Exploiting the Natural Diversity in Adenovirus Tropism for Therapy and Prevention of Disease

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RGD Inclusion in the Hexon Monomer Provides Adenovirus Type 5-Based Vectors with a Fiber Knob-Independent Pathway for Infection

Vigne, E., Mahfouz, I., Dedieu, J.-F., Brie, A., Perricaudet, M., & Yeh, P. (1999) · Journal of Virology · doi:10.1128/jvi.73.6.5156-5161.1999 · Cited by 191 · see citing works

Transposition from a gutless adeno-transposon vector stabilizes transgene expression in vivo

Yant, S. R., Ehrhardt, A., Mikkelsen, J. G., Meuse, L. A., Pham, T. N. D., & Kay, M. A. (2002) · Nature Biotechnology · doi:10.1038/nbt738 · Cited by 188 · see citing works

The importance of being acid: the role of acidification in intracellular membrane traffic

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Signalling in viral entry

Greber, U. F. (2002) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-002-8453-3 · Cited by 186 · see citing works

The First Step of Adenovirus Type 2 Disassembly Occurs at the Cell Surface, Independently of Endocytosis and Escape to the Cytosol

Nakano, M. Y., Boucke, K., Suomalainen, M., Stidwill, R. P., & Greber, U. F. (2000) · Journal of Virology · doi:10.1128/jvi.74.15.7085-7095.2000 · Cited by 186 · see citing works

Cryo‐EM visualization of an exposed RGD epitope on adenovirus that escapes antibody neutralization

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Identification of Contact Residues and Definition of the CAR-Binding Site of Adenovirus Type 5 Fiber Protein

Kirby, I., Davison, E., Beavil, A. J., Soh, C., Wickham, T. J., Roelvink, P. W., Kovesdi, I., Sutton, B. J., & Santis, G. (2000) · Journal of Virology · doi:10.1128/jvi.74.6.2804-2813.2000 · Cited by 180 · see citing works

Targeted adenoviral vectors

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Structure of Adenovirus Complexed with Its Internalization Receptor, α v β5 Integrin

Chiu, C. Y., Mathias, P., Nemerow, G. R., & Stewart, P. L. (1999) · Journal of Virology · doi:10.1128/jvi.73.8.6759-6768.1999 · Cited by 171 · see citing works

Structure and composition of the adenovirus type 2 core

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CD46 Is a Cellular Receptor for All Species B Adenoviruses except Types 3 and 7

Marttila, M., Persson, B. D., Gustafsson, D. J., Liszewski, M. K., Atkinson, J. P., Wadell, G., & Arnberg, N. (2005) · Journal of Virology · doi:10.1128/jvi.79.22.14429-14436.2005 · Cited by 167 · see citing works

PEGylation of E1-Deleted Adenovirus Vectors Allows Significant Gene Expression on Readministration to Liver

Croyle, M. A., Chirmule, N. B., Zhang, Y., & Wilson, J. M. (2002) · Human Gene Therapy · doi:10.1089/104303402760372972 · Cited by 166 · see citing works

Engineering of Adenovirus Vectors Containing Heterologous Peptide Sequences in the C Terminus of Capsid Protein IX

Dmitriev, I. P., Kashentseva, E. A., & Curiel, D. T. (2002) · Journal of Virology · doi:10.1128/jvi.76.14.6893-6899.2002 · Cited by 164 · see citing works

Adenovirus serotype 3 utilizes CD80 (B7.1) and CD86 (B7.2) as cellular attachment receptors

Short, J. J., Pereboev, A. V., Kawakami, Y., Vasu, C., Holterman, M., & Curiel, D. T. (2004) · Virology · doi:10.1016/j.virol.2004.02.016 · Cited by 164 · see citing works

Structural proteins of adenoviruses

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Flexibility of the Adenovirus Fiber Is Required for Efficient Receptor Interaction

Wu, E. Y., Pache, L., Seggern, D. J. V., Mullen, T.-M., Mikyas, Y., Stewart, P. L., & Nemerow, G. R. (2003) · Journal of Virology · doi:10.1128/jvi.77.13.7225-7235.2003 · Cited by 158 · see citing works

Fiber Swap between Adenovirus Subgroups B and C Alters Intracellular Trafficking of Adenovirus Gene Transfer Vectors

Miyazawa, N., Leopold, P. L., Hackett, N. R., Ferris, B., Worgall, S., Falck-Pedersen, E., & Crystal, R. G. (1999) · Journal of Virology · doi:10.1128/jvi.73.7.6056-6065.1999 · Cited by 157 · see citing works

Type-Specific Epitope Locations Revealed by X-Ray Crystallographic Study of Adenovirus Type 5 Hexon

Rux, J. J., & Burnett, R. M. (2000) · Molecular Therapy · doi:10.1006/mthe.1999.0001 · Cited by 157 · see citing works

Adenovirus Type 5 Interactions with Human Blood Cells May Compromise Systemic Delivery

Lyons, M. J., Onion, D., Green, N. K., Aslan, K., Rajaratnam, R., Bazán‐Peregrino, M., PHIPPS, S. L., Hale, S. J. M., Mautner, V., Seymour, L. W., et al. (2006) · Molecular Therapy · doi:10.1016/j.ymthe.2006.01.003 · Cited by 156 · see citing works

A New Group B Adenovirus Receptor Is Expressed at High Levels on Human Stem and Tumor Cells

Tuve, S., Wang, H., Ware, C. B., Liu, Y., Gaggar, A., Bernt, K. M., Shayakhmetov, D. M., Li, Z., Strauss, R., Stone, D., et al. (2006) · Journal of Virology · doi:10.1128/jvi.01370-06 · Cited by 154 · see citing works

Cytoplasmic Dynein Mediates Adenovirus Binding to Microtubules

Kelkar, S., Pfister, K. K., Crystal, R. G., & Leopold, P. L. (2004) · Journal of Virology · doi:10.1128/jvi.78.18.10122-10132.2004 · Cited by 153 · see citing works

Structural proteins of adenoviruses

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The Role of Capsid–Endothelial Interactions in the Innate Immune Response to Adenovirus Vectors

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