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Cited by 384

The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.

Expression of the Zinc-Finger Antiviral Protein Inhibits Alphavirus Replication

Open access
Bick, Matthew J., Carroll, John-William N., Gao, Guangxia, Goff, Stephen P., Rice, Charles M., MacDonald, Margaret R.·2003·Journal of Virology
DOI 10.1128/jvi.77.21.11555-11562.2003
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Abstract

The rat zinc-finger antiviral protein (ZAP) was recently identified as a host protein conferring resistance to retroviral infection. We analyzed ZAP's ability to inhibit viruses from other families and found that ZAP potently inhibits the replication of multiple members of the Alphavirus genus within the Togaviridae , including Sindbis virus, Semliki Forest virus, Ross River virus, and Venezuelan equine encephalitis virus. However, expression of ZAP did not induce a broad-spectrum antiviral state as some viruses, including vesicular stomatitis virus, poliovirus, yellow fever virus, and herpes simplex virus type 1, replicated to normal levels in ZAP-expressing cells. We determined that ZAP expression inhibits Sindbis virus replication after virus penetration and entry, but before the amplification of newly synthesized plus strand genomic RNA. Using a temperature-sensitive Sindbis virus mutant expressing luciferase, we further showed that translation of incoming viral RNA is blocked by ZAP expression. Elucidation of the antiviral mechanism by which ZAP inhibits Sindbis virus translation may lead to the development of agents with broad activity against alphaviruses.

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Metadata

Authors
Bick, M. J., Carroll, J.-W. N., Gao, G., Goff, S. P., Rice, C. M., & MacDonald, M. R.
Venue
Journal of Virology
Publisher
American Society for Microbiology
Published
2003-11
Volume
77
Issue
21
Pages
11555-11562
ISSN
  • 0022-538X (ISSN-L)
  • 1098-5514
DOI
10.1128/jvi.77.21.11555-11562.2003
OpenAlex
W2134631240
Cited by
384
References
20
FWCI
7.58
Type
journal article
Language
en
Open access
green

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The paper
Bick, M. J., Carroll, J.-W. N., Gao, G., Goff, S. P., Rice, C. M., & MacDonald, M. R. (2003). Expression of the Zinc-Finger Antiviral Protein Inhibits Alphavirus Replication. Journal of Virology. https://doi.org/10.1128/jvi.77.21.11555-11562.2003

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.