The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
The Natural Host Range Shift and Subsequent Evolution of Canine Parvovirus Resulted from Virus-Specific Binding to the Canine Transferrin Receptor
Open accessAbstract
Canine parvovirus (CPV) is a host range variant of a feline virus that acquired the ability to infect dogs through changes in its capsid protein. Canine and feline viruses both use the feline transferrin receptor (TfR) to infect feline cells, and here we show that CPV infects canine cells through its ability to specifically bind the canine TfR. Receptor binding on host cells at 37°C only partially correlated with the host ranges of the viruses, and an intermediate virus strain (CPV type 2) bound to higher levels on cells than did either the feline panleukopenia virus or a later strain of CPV. During the process of adaptation to dogs the later variant strain of CPV gained the ability to more efficiently use the canine TfR for infection and also showed reduced binding to feline and canine cells compared to CPV type 2. Differences on the top and the side of the threefold spike of the capsid surface controlled specific TfR binding and the efficiency of binding to feline and canine cells, and these differences also determined the cell infection properties of the viruses.
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Cites
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Self-citationSialic Acid Species as a Determinant of the Host Range of Influenza A Viruses
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Self-citationCrystal structure of the hereditary haemochromatosis protein HFE complexed with transferrin receptor
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Self-citationViral infection and iron metabolism
Drakesmith, H., & Prentice, A. (2008) · Nature Reviews Microbiology · doi:10.1038/nrmicro1930 · Cited by 469
Structure of Adeno-Associated Virus Serotype 5
Walters, R. W., Agbandje-McKenna, M., Bowman, V. D., Moninger, T. O., Olson, N. H., Seiler, M., Chiorini, J. A., Baker, T. S., & Zabner, J. (2004) · Journal of Virology · doi:10.1128/jvi.78.7.3361-3371.2004 · Cited by 114
Heparin binding induces conformational changes in Adeno-associated virus serotype 2
Levy, H. C., Bowman, V. D., Govindasamy, L., McKenna, R., Nash, K., Warrington, K., Chen, W., Muzyczka, N., Yan, X., Baker, T. S., et al. (2009) · Journal of Structural Biology · doi:10.1016/j.jsb.2008.12.002 · Cited by 110
“The binding site for the CPV transferrin receptor was mapped by mutagenesis and cryo-reconstruction to the raised portion of the capsid that lies between the icosahedral two- and fivefold axes (Hueffer et al., 2003a,b; Govindasamy et al., 2003; Hafenstein et al., 2007).”
Background
Metadata
- Authors
- Hueffer, K., Parker, J. S. L., Weichert, W. S., Geisel, R. E., Sgro, J.-Y., & Parrish, C. R.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 2003-02
- Volume
- 77
- Issue
- 3
- Pages
- 1718-1726
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W2108942487
- Cited by
- 263
- References
- 44
- FWCI
- 22.38
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: The Natural Host Range Shift and Subsequent Evolution of Canine Parvovirus Resulted from Virus-Specific Binding to the Canine Transferrin Receptor. https://app.cochat.ai/papers/10.1128/jvi.77.3.1718-1726.2003
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- Hueffer, K., Parker, J. S. L., Weichert, W. S., Geisel, R. E., Sgro, J.-Y., & Parrish, C. R. (2003). The Natural Host Range Shift and Subsequent Evolution of Canine Parvovirus Resulted from Virus-Specific Binding to the Canine Transferrin Receptor. Journal of Virology. https://doi.org/10.1128/jvi.77.3.1718-1726.2003
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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