The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Sialic Acid Species as a Determinant of the Host Range of Influenza A Viruses
Open accessAbstract
The distribution of sialic acid (SA) species varies among animal species, but the biological role of this variation is largely unknown. Influenza viruses differ in their ability to recognize SA-galactose (Gal) linkages, depending on the animal hosts from which they are isolated. For example, human viruses preferentially recognize SA linked to Gal by the α2,6(SAα2,6Gal) linkage, while equine viruses favor SAα2,3Gal. However, whether a difference in relative abundance of specific SA species ( N -acetylneuraminic acid [NeuAc] and N -glycolylneuraminic acid [NeuGc]) among different animals affects the replicative potential of influenza viruses is uncertain. We therefore examined the requirement for the hemagglutinin (HA) for support of viral replication in horses, using viruses whose HAs differ in receptor specificity. A virus with an HA recognizing NeuAcα2,6Gal but not NeuAcα2,3Gal or NeuGcα2,3Gal failed to replicate in horses, while one with an HA recognizing the NeuGcα2,3Gal moiety replicated in horses. Furthermore, biochemical and immunohistochemical analyses and a lectin-binding assay demonstrated the abundance of the NeuGcα2,3Gal moiety in epithelial cells of horse trachea, indicating that recognition of this moiety is critical for viral replication in horses. Thus, these results provide evidence of a biological effect of different SA species in different animals.
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Cites
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Self-citationHuman influenza A H5N1 virus related to a highly pathogenic avian influenza virus
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Self-citationChemistry, Metabolism, and Biological Functions of Sialic Acids
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Self-citationReceptor Specificity in Human, Avian, and Equine H2 and H3 Influenza Virus Isolates
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Self-citationOn the origin of the human influenza virus subtypes H2N2 and H3N2
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Cited by
Structure and Receptor Specificity of the Hemagglutinin from an H5N1 Influenza Virus
Stevens, J., Blixt, O., Tumpey, T. M., Taubenberger, J. K., Paulson, J. C., & Wilson, I. A. (2006) · Science · doi:10.1126/science.1124513 · Cited by 938
Host and viral determinants of influenza A virus species specificity
Long, J. S., Mistry, B., Haslam, S. M., & Barclay, W. S. (2019) · Nature Reviews Microbiology · doi:10.1038/s41579-018-0115-z · Cited by 667
A Genetic Approach to Mammalian Glycan Function
Lowe, J. B., & Marth, J. D. (2003) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.72.121801.161809 · Cited by 594
Molecular basis of the structure and function of H1 hemagglutinin of influenza virus
SRIWILAIJAROEN, N., & SUZUKI, Y. (2012) · Proceedings of the Japan Academy, Series B · doi:10.2183/pjab.88.226 · Cited by 270
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Metadata
- Authors
- Suzuki, Y., Ito, T., Suzuki, T., Holland, R. E., Chambers, T. M., Kiso, M., Ishida, H., & Kawaoka, Y.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 2000-12-15
- Volume
- 74
- Issue
- 24
- Pages
- 11825-11831
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W2132527856
- Cited by
- 512
- References
- 33
- FWCI
- 5.92
- Type
- journal article
- Language
- en
- Open access
- green
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- Suzuki, Y., Ito, T., Suzuki, T., Holland, R. E., Chambers, T. M., Kiso, M., Ishida, H., & Kawaoka, Y. (2000). Sialic Acid Species as a Determinant of the Host Range of Influenza A Viruses. Journal of Virology. https://doi.org/10.1128/jvi.74.24.11825-11831.2000
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