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Cited by 115Streptococcal Infections and TreatmentsInfluenza Virus Research StudiesMicrobial infections and disease research

The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.

Influenza A Virus-Infected Hosts Boost an Invasive Type of Streptococcus pyogenes Infection in Mice

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Okamoto, Shigefumi, Kawabata, Shigetada, Nakagawa, Ichiro, Okuno, Yoshinobu, Goto, Toshiyuki, Sano, Kouichi, Hamada, Shigeyuki·2003·Journal of Virology
DOI 10.1128/jvi.77.7.4104-4112.2003PMC PMC150641
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Abstract

The apparent worldwide resurgence of invasive Streptococcus pyogenes infection in the last two decades remains unexplained. At present, animal models in which toxic shock-like syndrome or necrotizing fasciitis is induced after S. pyogenes infection are not well developed. We demonstrate here that infection with a nonlethal dose of influenza A virus 2 days before intranasal infection with a nonlethal dose of S. pyogenes strains led to a death rate of more than 90% in mice, 10% of which showed necrotizing fasciitis. Infection of lung alveolar epithelial cells by the influenza A virus resulted in viral hemagglutinin expression on the cell surface and promoted internalization of S. pyogenes. However, treatment with monoclonal antibodies to hemagglutinin markedly decreased this internalization. Our results indicate that prior infection with influenza A virus induces a lethal synergism, resulting in the induction of invasive S. pyogenes infection in mice.

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Metadata

Authors
Okamoto, S., Kawabata, S., Nakagawa, I., Okuno, Y., Goto, T., Sano, K., & Hamada, S.
Affiliations
  • The University of Osaka (JP)
  • Japan Science and Technology Agency (JP)
  • Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, Suita-Osaka 565-0871
  • Osaka Prefectural Institute of Public Health (JP)
  • Osaka Medical and Pharmaceutical University (JP)
ORCID
Venue
Journal of Virology
Publisher
American Society for Microbiology
Published
2003-04
Volume
77
Issue
7
Pages
4104-4112
ISSN
  • 0022-538X (ISSN-L)
  • 1098-5514
DOI
10.1128/jvi.77.7.4104-4112.2003
PMC
PMC150641
OpenAlex
W2143002313
Cited by
114
References
39
Citations by year
2026: 5 · 2025: 6 · 2024: 8 · 2023: 1 · 2022: 5 · 2021: 3 · 2020: 4 · 2019: 4 · 2018: 5 · 2017: 3 · 2016: 4 · 2015: 5 · 2014: 5 · 2013: 2 · 2012: 6
FWCI
6.78
Type
journal article
Language
en
Open access
Licence
journals.asm.org/non-commercial-tdm-license (tdm)
Locations
  • Journal of Virology (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Japan Science and Technology Corporation
  • Precursory Research for Embryonic Science and Technology
Topics
  • Health Sciences › Medicine › Infectious Diseases › Streptococcal Infections and Treatments
  • Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
  • Life Sciences › Immunology and Microbiology › Microbiology › Microbial infections and disease research
Keywords
Streptococcus pyogenes, invasive streptococcal infection, influenza A virus, viral-bacterial coinfection, necrotizing fasciitis, toxic shock-like syndrome, hemagglutinin, bacterial internalization, alveolar epithelial cells, monoclonal antibodies, synergistic infection, mouse model
MeSH terms
Animals, Antibodies, Monoclonal, Antibodies, Viral, Cell Line, Female, Hemagglutinins, Viral, Humans, Influenza, Human, Mice, Inbred BALB C, Microscopy, Electron, Influenza A virus, Streptococcal Infections, Streptococcus pyogenes, Tumor Necrosis Factor-alpha, Virulence, Superinfection, Interleukin-6, Fasciitis, Necrotizing, Mice

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