Cited by 115Streptococcal Infections and TreatmentsInfluenza Virus Research StudiesMicrobial infections and disease research

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Influenza A Virus-Infected Hosts Boost an Invasive Type of Streptococcus pyogenes Infection in Mice

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Okamoto, Shigefumi, Kawabata, Shigetada, Nakagawa, Ichiro, Okuno, Yoshinobu, Goto, Toshiyuki, Sano, Kouichi, Hamada, Shigeyuki·2003·Journal of Virology

DOI 10.1128/jvi.77.7.4104-4112.2003PMC PMC150641

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Abstract

The apparent worldwide resurgence of invasive Streptococcus pyogenes infection in the last two decades remains unexplained. At present, animal models in which toxic shock-like syndrome or necrotizing fasciitis is induced after S. pyogenes infection are not well developed. We demonstrate here that infection with a nonlethal dose of influenza A virus 2 days before intranasal infection with a nonlethal dose of S. pyogenes strains led to a death rate of more than 90% in mice, 10% of which showed necrotizing fasciitis. Infection of lung alveolar epithelial cells by the influenza A virus resulted in viral hemagglutinin expression on the cell surface and promoted internalization of S. pyogenes. However, treatment with monoclonal antibodies to hemagglutinin markedly decreased this internalization. Our results indicate that prior infection with influenza A virus induces a lethal synergism, resulting in the induction of invasive S. pyogenes infection in mice.

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Authors: Okamoto, S., Kawabata, S., Nakagawa, I., Okuno, Y., Goto, T., Sano, K., & Hamada, S.
Affiliations: The University of Osaka (JP)
Japan Science and Technology Agency (JP)
Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, Suita-Osaka 565-0871
Osaka Prefectural Institute of Public Health (JP)
Osaka Medical and Pharmaceutical University (JP)
ORCID: Okamoto, Shigefumi
Kawabata, Shigetada
Goto, Toshiyuki
Hamada, Shigeyuki
Venue: Journal of Virology
Publisher: American Society for Microbiology
Published: 2003-04
Volume: 77
Issue: 7
Pages: 4104-4112
ISSN: 0022-538X (ISSN-L)
1098-5514
DOI: 10.1128/jvi.77.7.4104-4112.2003
PMC: PMC150641
OpenAlex: W2143002313
Cited by: 114
References: 39
Citations by year: 2026: 5 · 2025: 6 · 2024: 8 · 2023: 1 · 2022: 5 · 2021: 3 · 2020: 4 · 2019: 4 · 2018: 5 · 2017: 3 · 2016: 4 · 2015: 5 · 2014: 5 · 2013: 2 · 2012: 6
FWCI: 6.78
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Journal of Virology (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Japan Science and Technology Corporation
Precursory Research for Embryonic Science and Technology
Topics: Health Sciences › Medicine › Infectious Diseases › Streptococcal Infections and Treatments
Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
Life Sciences › Immunology and Microbiology › Microbiology › Microbial infections and disease research
Keywords: Streptococcus pyogenes, invasive streptococcal infection, influenza A virus, viral-bacterial coinfection, necrotizing fasciitis, toxic shock-like syndrome, hemagglutinin, bacterial internalization, alveolar epithelial cells, monoclonal antibodies, synergistic infection, mouse model
MeSH terms: Animals, Antibodies, Monoclonal, Antibodies, Viral, Cell Line, Female, Hemagglutinins, Viral, Humans, Influenza, Human, Mice, Inbred BALB C, Microscopy, Electron, Influenza A virus, Streptococcal Infections, Streptococcus pyogenes, Tumor Necrosis Factor-alpha, Virulence, Superinfection, Interleukin-6, Fasciitis, Necrotizing, Mice

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Influenza A Virus-Infected Hosts Boost an Invasive Type of Streptococcus pyogenes Infection in Mice

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