The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Envelope Protein Glycosylation Status Influences Mouse Neuroinvasion Phenotype of Genetic Lineage 1 West Nile Virus Strains
Open accessAbstract
The introduction of West Nile virus(WNV) into North America has been associated with relatively high rates of neurological disease and death in humans, birds, horses, and some other animals. Previous studies identified strains in both genetic lineage 1 and genetic lineage 2, including North American isolates of lineage 1, that were highly virulent in a mouse neuroinvasion model, while other strains were avirulent or significantly attenuated (D. W. C. Beasley, L. Li, M. T. Suderman, and A. D. T. Barrett, Virology 296:17-23, 2002). To begin to elucidate the basis for these differences, we compared a highly virulent New York 1999 (NY99) isolate with a related Old World lineage 1 strain, An4766 (ETH76a), which is attenuated for mouse neuroinvasion. Genomic sequencing of ETH76a revealed a relatively small number of nucleotide (5.1%) and amino acid (0.6%) differences compared with NY99. These differences were located throughout the genome and included five amino acid differences in the envelope protein gene. Substitution of premembrane and envelope genes of ETH76a into a NY99 infectious clone backbone yielded a virus with altered in vitro growth characteristics and a mouse virulence phenotype comparable to ETH76a. Further site-specific mutagenesis studies revealed that the altered phenotype was primarily mediated via loss of envelope protein glycosylation and that this was associated with altered stability of the virion at mildly acidic pH. Therefore, the enhanced virulence of North American WNV strains compared with other Old World lineage 1 strains is at least partly mediated by envelope protein glycosylation.
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The envelope glycoprotein from tick-borne encephalitis virus at 2 Å resolution
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The Outbreak of West Nile Virus Infection in the New York City Area in 1999
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A ligand-binding pocket in the dengue virus envelope glycoprotein
Modis, Y., Ogata, S., Clements, D., & Harrison, S. C. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0832193100 · Cited by 1,061
The Fusion Glycoprotein Shell of Semliki Forest Virus
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Self-citationXiao, S.-Y., Guzman, H., Zhang, H., Travassos da Rosa, A. P. A., & Tesh, R. B. (2001) · Emerging Infectious Diseases · doi:10.3201/eid0704.010420 · Cited by 267
Mouse Neuroinvasive Phenotype of West Nile Virus Strains Varies Depending upon Virus Genotype
Beasley, D. W. C., Li, L., Suderman, M. T., & Barrett, A. D. T. (2002) · Virology · doi:10.1006/viro.2002.1372 · Cited by 240
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A CRISPR screen defines a signal peptide processing pathway required by flaviviruses
Zhang, R., Miner, J. J., Gorman, M. J., Rausch, K., Ramage, H., White, J. P., Zuiani, A., Zhang, P., Fernandez, E., Zhang, Q., et al. (2016) · Nature · doi:10.1038/nature18625 · Cited by 369
May, F. J., Davis, C. T., Tesh, R. B., & Barrett, A. D. T. (2011) · Journal of Virology · doi:10.1128/jvi.01963-10 · Cited by 280
Self-citationZika Virus Structure, Maturation, and Receptors
Sirohi, D., & Kuhn, R. J. (2017) · The Journal of Infectious Diseases · doi:10.1093/infdis/jix515 · Cited by 265
Crystal Structure of the West Nile Virus Envelope Glycoprotein
Nybakken, G. E., Nelson, C. A., Chen, B. R., Diamond, M. S., & Fremont, D. H. (2006) · Journal of Virology · doi:10.1128/jvi.01125-06 · Cited by 264
Metadata
- Authors
- Beasley, D. W. C., Whiteman, M. C., Zhang, S., Huang, C. Y.-H., Schneider, B. S., Smith, D. R., Gromowski, G. D., Higgs, S., Kinney, R. M., & Barrett, A. D. T.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 2005-07
- Volume
- 79
- Issue
- 13
- Pages
- 8339-8347
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W2147100664
- Cited by
- 313
- References
- 38
- FWCI
- 17.14
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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