The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.
Mouse Mammary Tumor Virus Encodes a Self-Regulatory RNA Export Protein and Is a Complex Retrovirus
Open accessAbstract
Mouse mammary tumor virus (MMTV) has been classified as a simple retrovirus with two accessory genes,dut and sag. Cloned MMTV proviruses carrying a trimethoprim (trim) cassette in the envelope gene were defective for Gag protein production and the nuclear export of unspliced gag-pol RNA. Complementation experiments indicated that a trans-acting product was responsible for the Gag defect of such mutants. Analysis of MMTV-infected cells revealed the presence of a novel, doubly spliced RNA that encodes a putative product of 301 amino acids. Overexpression of cDNA from this RNA increased Gag levels from env mutant proviruses or reporter gene expression from unspliced mRNAs and allowed detection of a 33-kDa protein product, which has been named r egulator of e xport of MMTV m RNA, or Rem. The Rem N terminus has motifs similar to the Rev-like export proteins of complex retroviruses, and mutation of the nuclear localization signal (NLS) abolished RNA export and detection within the nucleus. The Rem C terminus has few identifiable features, but removal of this domain increased Rem-mediated export, suggesting an autoregulatory function. A reporter vector developed from the 3′ end of the MMTV provirus was Rem responsive and required both the presence of the MMTV env-U3 junction and a functional Crm1 pathway. The identification of a third accessory protein from a doubly spliced transcript suggests that MMTV is the first murine complex retrovirus to be documented. Manipulation of the MMTV genome may provide mouse models for human retroviral diseases, such as AIDS.
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“Similarly, MMTV encodes a protein called Regulator of Export of MMTV mRNA (Rem), which interacts with the Rem Responsive Element (RmRE) present at the 3′end of the genome within the env gene, but overlapping the 3′ LTR.”
From Beyond reverse transcription: molecular mechanisms and emerging paradigms in retroviral replication (2026) · cites this paper as Mertz et al. 2005
In the citing paper
“Like HIV-1, this element is found in both the unspliced and spliced RNAs (Fig. 9; Table 1) (Indik et al. 2005, Mertz et al. 2005, 2009, Müllner et al. 2008).”
From Beyond reverse transcription: molecular mechanisms and emerging paradigms in retroviral replication (2026) · cites this paper as Mertz et al. 2005
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Metadata
- Authors
- Mertz, J. A., Simper, M. S., Lozano, M. M., Payne, S. M., & Dudley, J. P.
- Affiliations
- The University of Texas at Austin (US)
- Corresponding author
- Dudley, Jaquelin P.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 2005-12-15
- Volume
- 79
- Issue
- 23
- Pages
- 14737-14747
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- PMC
- PMC1287593
- OpenAlex
- W2109377528
- Cited by
- 130
- References
- 58
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 2 · 2023: 3 · 2022: 8 · 2021: 3 · 2020: 7 · 2019: 7 · 2018: 6 · 2017: 4 · 2016: 4 · 2015: 12 · 2014: 6 · 2013: 6 · 2012: 8
- FWCI
- 1.90
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Virology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and Retrovirus Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Keywords
- mouse mammary tumor virus, RNA export, nuclear export, Gag protein, accessory genes, nuclear localization signal, murine retrovirus
- MeSH terms
- Animals, Mammary Tumor Virus, Mouse, RNA, Viral, Viral Proteins, Mice
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