Identification of a Functional Envelope Protein from the HERV-K Family of Human Endogenous Retroviruses

Dewannieux, Marie; Blaise, Sandra; Heidmann, Thierry

doi:10.1128/jvi.79.24.15573-15577.2005

Cited by 137Chromosomal and Genetic VariationsHIV Research and TreatmentEvolution and Genetic Dynamics

Identification of a Functional Envelope Protein from the HERV-K Family of Human Endogenous Retroviruses

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Dewannieux, Marie, Blaise, Sandra, Heidmann, Thierry·2005·Journal of Virology

DOI 10.1128/jvi.79.24.15573-15577.2005PMC PMC1315997

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Abstract

Genome-wide screening of sequence databases for human endogenous retroviruses (HERVs) has led to the identification of 18 coding env genes, among which two—the syncytin genes—encode fusogenic ENV proteins possibly involved in placenta physiology. Here we show that a third ENV, originating from the most “recent” HERV-K(HML2) family, is functional. Immunofluorescence analysis of env -transduced cells demonstrates expression of the protein at the cell surface, and we show that the protein confers infectivity to simian immunodeficiency virus pseudotypes. Western blot analysis of the pseudotyped virions further discloses the expected specific cleavage of the ENV precursor protein. This functional ENV could play a role in the amplification—via infection of the germ line—of the HERV-K genomic copies, all the more as coding HERV-K gag and pol genes can similarly be found in the human genome, which could therefore generate infectious virions of a fully endogenous origin.

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Retrovirus-like particles (RLPs) resemble retroviral vesicles on EM but are non-infectious, are defined by size 90-100 nm and a subset of retroviral proteins, arise by budding from the plasma membrane, and Gag protein may serve as a marker.
“Retrovirus-like Particles (RLPs) are those that resemble retroviral vesicles on EM but are non-infectious because they do not contain the full complement of genes required for cellular entry or viral propagation. These vesicles are typically defined by their size (90-100 nm) and the presence of a subset of retroviral proteins [69-72].”
From Biogenesis of extracellular vesicles (EV): exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies (2013) · cites this paper as [72]

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Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution
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Infectious Entry Pathway Mediated by the Human Endogenous Retrovirus K Envelope Protein
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Authors: Dewannieux, M., Blaise, S., & Heidmann, T.
Affiliations: Centre National de la Recherche Scientifique (FR)
Unité des Rétrovirus Endogènes et Eléments Rétroïdes des Eucaryotes Supérieurs, UMR 8122 CNRS, Institut Gustave Roussy, 94805 Villejuif, France
ORCID: Dewannieux, Marie
Venue: Journal of Virology
Publisher: American Society for Microbiology
Published: 2005-12-15
Volume: 79
Issue: 24
Pages: 15573-15577
ISSN: 0022-538X (ISSN-L)
1098-5514
DOI: 10.1128/jvi.79.24.15573-15577.2005
PMC: PMC1315997
OpenAlex: W2072583113
Cited by: 137
References: 23
Citations by year: 2026: 5 · 2025: 5 · 2024: 7 · 2023: 8 · 2022: 9 · 2021: 8 · 2020: 6 · 2019: 4 · 2018: 7 · 2017: 4 · 2016: 5 · 2015: 8 · 2014: 12 · 2013: 4 · 2012: 4
FWCI: 9.62
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Journal of Virology (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Centre National de la Recherche Scientifique
Topics: Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
Keywords: human endogenous retroviruses, envelope protein, syncytin, fusogenic proteins, syncytin-2, retroviral evolution, placenta
MeSH terms: Humans, Viral Proteins, Genes, env, Genome, Human, Endogenous Retroviruses

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Identification of a Functional Envelope Protein from the HERV-K Family of Human Endogenous Retroviruses

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