The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Metabolic Remodeling during Biofilm Development of Bacillus subtilis
Open accessAbstract
Bacterial biofilms are ubiquitous in natural environments and play an important role in many clinical, industrial, and ecological settings. Although much is known about the transcriptional regulatory networks that control biofilm formation in model bacteria such as Bacillus subtilis , very little is known about the role of metabolism in this complex developmental process. To address this important knowledge gap, we performed a time-resolved analysis of the metabolic changes associated with bacterial biofilm development in B. subtilis by combining metabolomic, transcriptomic, and proteomic analyses. Here, we report a widespread and dynamic remodeling of metabolism affecting central carbon metabolism, primary biosynthetic pathways, fermentation pathways, and secondary metabolism. This report serves as a unique hypothesis-generating resource for future studies on bacterial biofilm physiology. Outside the biofilm research area, this work should also prove relevant to any investigators interested in microbial physiology and metabolism.
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Extracellular DNA Required for Bacterial Biofilm Formation
Whitchurch, C. B., Tolker-Nielsen, T., Ragas, P. C., & Mattick, J. S. (2002) · Science · doi:10.1126/science.295.5559.1487 · Cited by 2,203
Absolute metabolite concentrations and implied enzyme active site occupancy in Escherichia coli
Bennett, B. D., Kimball, E. H., Gao, M., Osterhout, R., Van Dien, S. J., & Rabinowitz, J. D. (2009) · Nature Chemical Biology · doi:10.1038/nchembio.186 · Cited by 1,830
Fruiting body formation by Bacillus subtilis
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Pseudomonas biofilm formation and antibiotic resistance are linked to phenotypic variation
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Cited by
Bacillus subtilis: a universal cell factory for industry, agriculture, biomaterials and medicine
Su, Y., Liu, C., Fang, H., & Zhang, D. (2020) · Microbial Cell Factories · doi:10.1186/s12934-020-01436-8 · Cited by 531
Bacillus subtilis impact on plant growth, soil health and environment: Dr. Jekyll and Mr. Hyde
Mahapatra, S., Yadav, R., & Ramakrishna, W. (2022) · Journal of Applied Microbiology · doi:10.1111/jam.15480 · Cited by 285
Metadata
- Authors
- Pisithkul, T., Schroeder, J. W., Trujillo, E. A., Yeesin, P., Stevenson, D. M., Chaiamarit, T., Coon, J. J., Wang, J. D., & Amador-Noguez, D.
- Venue
- mBio
- Publisher
- American Society for Microbiology
- Published
- 2019-06-25
- Volume
- 10
- Issue
- 3
- ISSN
- 2150-7511 (ISSN-L)
- 2161-2129
- OpenAlex
- W2946290230
- Cited by
- 174
- References
- 12
- FWCI
- 4.94
- Type
- journal article
- Language
- en
- Open access
- gold
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- Pisithkul, T., Schroeder, J. W., Trujillo, E. A., Yeesin, P., Stevenson, D. M., Chaiamarit, T., Coon, J. J., Wang, J. D., & Amador-Noguez, D. (2019). Metabolic Remodeling during Biofilm Development of Bacillus subtilis. mBio. https://doi.org/10.1128/mbio.00623-19
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