The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.
Phage-Antibiotic Synergy Is Driven by a Unique Combination of Antibacterial Mechanism of Action and Stoichiometry
Open accessAbstract
Bacteriophage (phage) therapy is a promising approach to combat the rise of multidrug-resistant bacteria. Currently, the preferred clinical modality is to pair phage with an antibiotic, a practice thought to improve efficacy. However, antagonism between phage and antibiotics has been reported, the choice of phage and antibiotic is not often empirically determined, and the effect of the host factors on the effectiveness is unknown. Here, we interrogate phage-antibiotic interactions across antibiotics with different mechanisms of action. Our results suggest that phage can lower the working MIC for bacterial strains already resistant to the antibiotic, is dependent on the antibiotic class and stoichiometry of the pairing, and is dramatically influenced by the host microenvironment.
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Cites
Ultrastructural Characterization of the Lower Motor System in a Mouse Model of Krabbe Disease
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Limb proportions show developmental plasticity in response to embryo movement
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Cited by
Molecular mechanisms of antibiotic resistance revisited
Darby, E. M., Trampari, E., Siasat, P., Gaya, M. S., Alav, I., Webber, M. A., & Blair, J. M. A. (2023) · Nature Reviews Microbiology · doi:10.1038/s41579-022-00820-y · Cited by 1,398
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Self-citationNick, J. A., Dedrick, R. M., Gray, A. L., Vladar, E. K., Smith, B. E., Freeman, K. G., Malcolm, K. C., Epperson, L. E., Hasan, N. A., Hendrix, J., et al. (2022) · Cell · doi:10.1016/j.cell.2022.04.024 · Cited by 251
Islam, M. R., Martinez-Soto, C. E., Lin, J. T., Khursigara, C. M., Barbut, S., & Anany, H. (2023) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1984200 · Cited by 47
Mutalik, V. K., & Arkin, A. P. (2022) · iScience · doi:10.1016/j.isci.2022.104121 · Cited by 32
Metadata
- Authors
- Gu Liu, C., Green, S. I., Min, L., Clark, J. R., Salazar, K. C., Terwilliger, A. L., Kaplan, H. B., Trautner, B. W., Ramig, R. F., & Maresso, A. W.
- Venue
- mBio
- Publisher
- American Society for Microbiology
- Published
- 2020-08-25
- Volume
- 11
- Issue
- 4
- ISSN
- 2150-7511 (ISSN-L)
- 2161-2129
- OpenAlex
- W3047234466
- Cited by
- 409
- References
- 59
- FWCI
- 20.08
- Type
- journal article
- Language
- en
- Open access
- gold
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- CoChat. (2026). Citation check: Phage-Antibiotic Synergy Is Driven by a Unique Combination of Antibacterial Mechanism of Action and Stoichiometry. https://app.cochat.ai/papers/10.1128/mbio.01462-20
- The paper
- Gu Liu, C., Green, S. I., Min, L., Clark, J. R., Salazar, K. C., Terwilliger, A. L., Kaplan, H. B., Trautner, B. W., Ramig, R. F., & Maresso, A. W. (2020). Phage-Antibiotic Synergy Is Driven by a Unique Combination of Antibacterial Mechanism of Action and Stoichiometry. mBio. https://doi.org/10.1128/mbio.01462-20
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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