The Multifunctional Fungal Ergosterol
Open accessAbstract
The roles of ergosterol in the regulation of membrane fluidity and structure, as well its role as a target for the activity of antifungals, have been known for decades. Two recent studies, however, demonstrated that ergosterol is an immunologically active lipid that induces pyroptosis and that virtually all steps of its biosynthetic process are potential drug targets.
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Ergosterol biosynthesis pathway has been identified as traditional therapeutic target for invasive candidiasis.
“The ergosterol biosynthesis pathway has been identified as a traditional therapeutic target for addressing invasive candidiasis55.”
From Impairing the interaction between Erg11 and cytochrome P450 reductase Ncp1 enhances azoles’ antifungal activities (2025) · cites this paper as [55]
The section “ERGOSTEROL BIOSYNTHESIS PATHWAYS PROVIDE MULTIPLE TARGETS FOR ANTIFUNGAL DEVELOPMENT” says ergosterol biosynthesis is an established target of antifungal compounds and identifies existing drug classes that inhibit it. It discusses systemic mycoses generally, but does not specifically identify the pathway as a therapeutic target for invasive candidiasis. (LLM, conf=0.83)
Experimental — accuracy not yet measuredOther studies mentioned that the antifungal activities of ATO and other statin drugs can be attributed to the inhibition of ergosterol and isoprenoid-biosynthesis.
“Other studies mentioned that the antifungal activates of ATO and other statin drugs can be attributed to the inhibition of ergosterol and isoprenoid-biosynthesis are thought to result in these antifungal properties (Rahal et al. 2015; Rodrigues 2018; Lima et al. 2019)”
From In vitro study on the potential fungicidal effects of atorvastatin in combination with some azole drugs against multidrug resistant Candida albicans (2021) · cites this paper as Rodrigues 2018
The section “Ergosterol Biosynthesis Pathways Provide Multiple Targets for Antifungal Development” links lovastatin’s antifungal activity to genes in the ergosterol-biosynthesis pathway. It does not mention atorvastatin (ATO) or attribute statins’ antifungal activity to inhibition of isoprenoid biosynthesis; the claim therefore exceeds what this source supports. (LLM, conf=0.85)
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- Authors
- Rodrigues, M. L.
- Affiliations
- Instituto Carlos Chagas, Fundação Oswaldo Cruz (Fiocruz), Curitiba, Brazil
- ORCID
- Rodrigues, Marcio L.
- Venue
- mBio
- Publisher
- American Society for Microbiology
- Published
- 2018-11-07
- Volume
- 9
- Issue
- 5
- ISSN
- 2150-7511 (ISSN-L)
- 2161-2129
- PMC
- PMC6143734
- OpenAlex
- W2890570825
- Cited by
- 275
- References
- 20
- Citations by year
- 2026: 36 · 2025: 58 · 2024: 40 · 2023: 42 · 2022: 32 · 2021: 32 · 2020: 26 · 2019: 9
- FWCI
- 12.65
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- mBio (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Arca - Repositório Institucional da Fiocruz (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- MCTI | Conselho Nacional de Desenvolvimento Científico e Tecnológico (443586/2014-4)
- Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (E-26/202.997/2015)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Keywords
- ergosterol, fungal cell membrane, membrane fluidity, antifungal drug targets, ergosterol biosynthesis, pyroptosis, fungal immunology
- MeSH terms
- Pyroptosis, Antifungal Agents, Candida albicans, Ergosterol, Macrophages, Microbial Sensitivity Tests, Saccharomyces cerevisiae
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