Cited by 278Antifungal resistance and susceptibilityLipid Membrane Structure and BehaviorFungal and yeast genetics research

The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.

The Multifunctional Fungal Ergosterol

Open access
Rodrigues, Marcio L.·2018·mBio

Abstract

The roles of ergosterol in the regulation of membrane fluidity and structure, as well its role as a target for the activity of antifungals, have been known for decades. Two recent studies, however, demonstrated that ergosterol is an immunologically active lipid that induces pyroptosis and that virtually all steps of its biosynthetic process are potential drug targets.

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Registry

Crossref · 10.1128/mbio.01755-18

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Figures

FIG 1 The multiple roles of ergosterol in fungal cells. Ergosterol is a regulator of the fluidity of fungal membranes (left panel, classic view). On the basis of the structural differences between ergosterol and mammalian cholesterol, the antifungals allylamines, azoles, and morpholines can selectively inhibit 3 of the 25 enzymes required for biosynthesis of the fungal sterol. The studies by Koselny et al. (5) and Bhattacharya et al. (6) demonstrate novel roles for fungal ergosterol (right panel). Their observations imply that additional antifungal classes have the potential to target ergosterol biosynthesis and that this lipid interacts with the immune system, inducing pyroptosis. The immunological functions of ergosterol are compatible with the notion that this fungal sterol, rather than being limited to the plasma membrane, has a broad distribution in the fungal cell.
FIG 1 The multiple roles of ergosterol in fungal cells. Ergosterol is a regulator of the fluidity of fungal membranes (left panel, classic view). On the basis of the structural differences between ergosterol and mammalian cholesterol, the antifungals allylamines, azoles, and morpholines can selectively inhibit 3 of the 25 enzymes required for biosynthesis of the fungal sterol. The studies by Koselny et al. (5) and Bhattacharya et al. (6) demonstrate novel roles for fungal ergosterol (right panel). Their observations imply that additional antifungal classes have the potential to target ergosterol biosynthesis and that this lipid interacts with the immune system, inducing pyroptosis. The immunological functions of ergosterol are compatible with the notion that this fungal sterol, rather than being limited to the plasma membrane, has a broad distribution in the fungal cell.CC BY · PubMed Central

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Research works printed but not linked: 1

  1. GAFFI. 2018. Global fund for fungal infections. GAFFI, Geneva, Switzerland.

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Metadata

Authors
Rodrigues, M. L.
Affiliations
Instituto Carlos Chagas, Fundação Oswaldo Cruz (Fiocruz), Curitiba, Brazil
Venue
mBio
Published
2018-11-07
Volume
9
Issue
5
ISSN
  • 2150-7511 (ISSN-L)
  • 2161-2129
OpenAlex
W2890570825
Cited by
275
References
20
Citations by year
2026: 36 · 2025: 58 · 2024: 40 · 2023: 42 · 2022: 32 · 2021: 32 · 2020: 26 · 2019: 9
FWCI
12.65
Type
journal article
Language
en
Open access
Locations
  • mBio (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Arca - Repositório Institucional da Fiocruz (submittedVersion, other-oa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
  • MCTI | Conselho Nacional de Desenvolvimento Científico e Tecnológico (443586/2014-4)
  • Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (E-26/202.997/2015)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Keywords
ergosterol, fungal cell membrane, membrane fluidity, antifungal drug targets, ergosterol biosynthesis, pyroptosis, fungal immunology
MeSH terms
Pyroptosis, Antifungal Agents, Candida albicans, Ergosterol, Macrophages, Microbial Sensitivity Tests, Saccharomyces cerevisiae

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