The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
The Multifunctional Fungal Ergosterol
Open accessAbstract
The roles of ergosterol in the regulation of membrane fluidity and structure, as well its role as a target for the activity of antifungals, have been known for decades. Two recent studies, however, demonstrated that ergosterol is an immunologically active lipid that induces pyroptosis and that virtually all steps of its biosynthetic process are potential drug targets.
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“The ergosterol biosynthesis pathway has been identified as a traditional therapeutic target for addressing invasive candidiasis55.”
From Impairing the interaction between Erg11 and cytochrome P450 reductase Ncp1 enhances azoles’ antifungal activities (2025) · cites this paper as [55]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Other studies mentioned that the antifungal activates of ATO and other statin drugs can be attributed to the inhibition of ergosterol and isoprenoid-biosynthesis are thought to result in these antifungal properties (Rahal et al. 2015; Rodrigues 2018; Lima et al. 2019)”
From In vitro study on the potential fungicidal effects of atorvastatin in combination with some azole drugs against multidrug resistant Candida albicans (2021) · cites this paper as Rodrigues 2018
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Citations
Cites
Man, S. M., Karki, R., & Kanneganti, T. (2017) · Immunological Reviews · doi:10.1111/imr.12534 · Cited by 1,684
The Fungal Cell Wall: Structure, Biosynthesis, and Function
Gow, N. A. R., Latge, J.-P., & Munro, C. A. (2017) · Microbiology Spectrum · doi:10.1128/microbiolspec.funk-0035-2016 · Cited by 1,423
Rodrigues, M. L., Nimrichter, L., Oliveira, D. L., Frasés, S., de Miranda, K. R., Zaragoza, Ó., Alvarez, M., Nakouzi, A. S., Feldmesser, M., & Casadevall, A. (2006) · Eukaryotic Cell · doi:10.1128/ec.00318-06 · Cited by 495
Self-citationCompositional and immunobiological analyses of extracellular vesicles released by Candida albicans
Vargas, G., Rocha, J., Oliveira, D. L., Albuquerque, P., Frases, S., Santos, S. S., Nosanchuk, J., Gomes, A. M. O., Medeiros, L., Miranda, K., et al. (2015) · Cellular Microbiology · doi:10.1111/cmi.12374 · Cited by 274
Self-citationKarki, R., Man, S. M., Malireddi, R. K. S., Gurung, P., Vogel, P., Lamkanfi, M., & Kanneganti, T.-D. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.01.006 · Cited by 272
Global analysis of fungal morphology exposes mechanisms of host cell escape
O’Meara, T. R., Veri, A. O., Ketela, T., Jiang, B., Roemer, T., & Cowen, L. E. (2015) · Nature Communications · doi:10.1038/ncomms7741 · Cited by 243
Candida albicans Triggers NLRP3-Mediated Pyroptosis in Macrophages
Wellington, M., Koselny, K., Sutterwala, F. S., & Krysan, D. J. (2014) · Eukaryotic Cell · doi:10.1128/ec.00336-13 · Cited by 227
Role of Candida albicans Transcription Factor Upc2p in Drug Resistance and Sterol Metabolism
Silver, P. M., Oliver, B. G., & White, T. C. (2004) · Eukaryotic Cell · doi:10.1128/ec.3.6.1391-1397.2004 · Cited by 216
Bhattacharya, S., Esquivel, B. D., & White, T. C. (2018) · mBio · doi:10.1128/mbio.01291-18 · Cited by 210
Plasma membrane lipids and their role in fungal virulence
Rella, A., Farnoud, A. M., & Poeta, M. D. (2015) · Progress in Lipid Research · doi:10.1016/j.plipres.2015.11.003 · Cited by 150
Research works printed but not linked: 1
- GAFFI. 2018. Global fund for fungal infections. GAFFI, Geneva, Switzerland.
Cited by
Sorted by citations
Candida auris: Epidemiology, biology, antifungal resistance, and virulence
Du, H., Bing, J., Hu, T., Ennis, C. L., Nobile, C. J., & Huang, G. (2020) · PLOS Pathogens · doi:10.1371/journal.ppat.1008921 · Cited by 609
Regulation of Ergosterol Biosynthesis in Saccharomyces cerevisiae
Jordá, T., & Puig, S. (2020) · Genes · doi:10.3390/genes11070795 · Cited by 489
Amphotericin B and Other Polyenes—Discovery, Clinical Use, Mode of Action and Drug Resistance
Carolus, H., Pierson, S., Lagrou, K., & Dijck, P. V. (2020) · Journal of Fungi · doi:10.3390/jof6040321 · Cited by 387
Virulence Factors in Candida species
Staniszewska, M. (2019) · Current Protein and Peptide Science · doi:10.2174/1389203720666190722152415 · Cited by 285
Carvacrol—A Natural Phenolic Compound with Antimicrobial Properties
Mączka, W. K., Twardawska, M., Grabarczyk, M., & Wińska, K. (2023) · Antibiotics · doi:10.3390/antibiotics12050824 · Cited by 272
Metadata
- Authors
- Rodrigues, M. L.
- Affiliations
- Instituto Carlos Chagas, Fundação Oswaldo Cruz (Fiocruz), Curitiba, Brazil
- ORCID
- Rodrigues, Marcio L.
- Venue
- mBio
- Publisher
- American Society for Microbiology
- Published
- 2018-11-07
- Volume
- 9
- Issue
- 5
- ISSN
- 2150-7511 (ISSN-L)
- 2161-2129
- PMC
- PMC6143734
- OpenAlex
- W2890570825
- Cited by
- 275
- References
- 20
- Citations by year
- 2026: 36 · 2025: 58 · 2024: 40 · 2023: 42 · 2022: 32 · 2021: 32 · 2020: 26 · 2019: 9
- FWCI
- 12.65
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- mBio (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Arca - Repositório Institucional da Fiocruz (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- MCTI | Conselho Nacional de Desenvolvimento Científico e Tecnológico (443586/2014-4)
- Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (E-26/202.997/2015)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Keywords
- ergosterol, fungal cell membrane, membrane fluidity, antifungal drug targets, ergosterol biosynthesis, pyroptosis, fungal immunology
- MeSH terms
- Pyroptosis, Antifungal Agents, Candida albicans, Ergosterol, Macrophages, Microbial Sensitivity Tests, Saccharomyces cerevisiae
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