Extracellular vesicles contribute to mixed-fungal species competition during biofilm initiation
Open accessAbstract
Candida species commonly form mixed-species biofilms with other Candida species and bacteria. In the established biofilm state, vesicle cargo delivers public goods to support the mature community.
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Several Candida species produce a unique biofilm extracellular matrix mannan-glucan complex that is delivered via EVs.
“Several Candida species produce a unique biofilm extracellular matrix mannan-glucan complex that is delivered via EVs (25–28).”
From Dual function of <i>Candida auris</i> mannosyltransferase, MNT5, in biofilm community protection from antifungal therapy and the host (2025) · cites this paper as [26]
The Observation section (page not specified) says that several Candida species secrete core polysaccharides in extracellular vesicles and links vesicle cargo to biofilm matrix production. It does not identify that cargo as a unique mannan-glucan complex or establish that such a complex is delivered via EVs. (LLM, conf=0.86)
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Cites
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Cited by
Sorted by citations
Mechanisms of pathogenicity for the emerging fungus Candida auris
Horton, M. V., Holt, A. M., & Nett, J. E. (2023) · PLOS Pathogens · doi:10.1371/journal.ppat.1011843 · Cited by 67 · see citing works
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Self-citation
- Authors
- Zarnowski, R., Massey, J., Mitchell, A. P., & Andes, D.
- Affiliations
- Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA
- University of Wisconsin–Madison (US)
- University of Georgia (US)
- Corresponding author
- Andes, David
- Venue
- mBio
- Publisher
- American Society for Microbiology
- Published
- 2022-12-20
- Volume
- 13
- Issue
- 6
- Pages
- e0298822-e0298822
- ISSN
- 2150-7511 (ISSN-L)
- PMC
- PMC9765065
- OpenAlex
- W4309100066
- Cited by
- 15
- References
- 4
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 2 · 2023: 3
- FWCI
- 1.22
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- mBio (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- HHS | NIH | National Institute of Allergy and Infectious Diseases (R01AI073289)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Keywords
- extracellular vesicles, polymicrobial biofilms, Candida, fungal competition, biofilm initiation, public goods, interspecies communication, yeast-bacteria interactions
- MeSH terms
- Extracellular Vesicles, Candida, Candida albicans, Extracellular Matrix, Biofilms
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