Cited by 710RNA Research and SplicingRNA Interference and Gene DeliveryRNA and protein synthesis mechanisms

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P-Body Formation Is a Consequence, Not the Cause, of RNA-Mediated Gene Silencing

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Eulalio, Ana, Behm-Ansmant, Isabelle, Schweizer, Daniel, Izaurralde, Elisa·2007·Molecular and Cellular Biology

DOI 10.1128/mcb.00128-07PMC PMC1900022

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Abstract

P bodies are cytoplasmic domains that contain proteins involved in diverse posttranscriptional processes, such as mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing. The localization of these proteins and their targets in P bodies raises the question of whether their spatial concentration in discrete cytoplasmic domains is required for posttranscriptional gene regulation. We show that processes such as mRNA decay, NMD, and RNA-mediated gene silencing are functional in cells lacking detectable microscopic P bodies. Although P bodies are not required for silencing, blocking small interfering RNA or microRNA silencing pathways at any step prevents P-body formation, indicating that P bodies arise as a consequence of silencing. Consistently, we show that releasing mRNAs from polysomes is insufficient to trigger P-body assembly: polysome-free mRNAs must enter silencing and/or decapping pathways to nucleate P bodies. Thus, even though P-body components play crucial roles in mRNA silencing and decay, aggregation into P bodies is not required for function but is instead a consequence of their activity.

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Langridge, C. A., & Sontag, E. M. (2026) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2026.113271

Authors: Eulalio, A., Behm-Ansmant, I., Schweizer, D., & Izaurralde, E.
Affiliations: MPI for Developmental Biology, Spemannstrasse 35, D-72076 Tübingen, Germany
Max Planck Institute for Developmental Biology (DE)
Corresponding author: Izaurralde, Elisa
ORCID: Izaurralde, Elisa
Venue: Molecular and Cellular Biology
Publisher: Informa UK Limited
Published: 2007-06-01
Volume: 27
Issue: 11
Pages: 3970-3981
ISSN: 0270-7306 (ISSN-L)
1098-5549
DOI: 10.1128/mcb.00128-07
PMC: PMC1900022
OpenAlex: W2101555571
Cited by: 710
References: 62
Citations by year: 2026: 18 · 2025: 20 · 2024: 25 · 2023: 26 · 2022: 34 · 2021: 33 · 2020: 30 · 2019: 26 · 2018: 31 · 2017: 29 · 2016: 30 · 2015: 32 · 2014: 40 · 2013: 45 · 2012: 58
FWCI: 22.81
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Molecular and Cellular Biology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion, other-oa)
Max Planck Institute for Plasma Physics (submittedVersion)
Funders: European Molecular Biology Organization
Max-Planck-Gesellschaft
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
Keywords: P-bodies, RNA-mediated gene silencing, siRNA, microRNA, nonsense-mediated mRNA decay, mRNA degradation, post-transcriptional regulation, polysome association, mRNA decapping
MeSH terms: Animals, Drosophila melanogaster, Humans, Polyribosomes, Ribonucleoproteins, RNA, Messenger, Gene Silencing, RNA Stability, Cytoplasmic Structures, Drosophila Proteins, RNA, Small Interfering, MicroRNAs

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P-Body Formation Is a Consequence, Not the Cause, of RNA-Mediated Gene Silencing

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