The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Bmp2 Is Critical for the Murine Uterine Decidual Response
Open accessAbstract
The process of implantation, necessary for all viviparous birth, consists of tightly regulated events, including apposition of the blastocyst, attachment to the uterine lumen, and differentiation of the uterine stroma. In rodents and primates the uterine stroma undergoes a process called decidualization. Decidualization, the process by which the uterine endometrial stroma proliferates and differentiates into large epithelioid decidual cells, is critical to the establishment of fetal-maternal communication and the progression of implantation. The role of bone morphogenetic protein 2 (Bmp2) in regulating the transformation of the uterine stroma during embryo implantation in the mouse was investigated by the conditional ablation of Bmp2 in the uterus using the (PR-cre) mouse. Bmp2 gene ablation was confirmed by real-time PCR analysis in the PR-cre; Bmp2fl/fl (termed Bmp2d/d) uterus. While littermate controls average 0.9 litter of 6.2+/-0.7 pups per month, Bmp2d/d females are completely infertile. Analysis of the infertility indicates that whereas embryo attachment is normal in the Bmp2d/d as in control mice, the uterine stroma is incapable of undergoing the decidual reaction to support further embryonic development. Recombinant human BMP2 can partially rescue the decidual response, suggesting that the observed phenotypes are not due to a developmental consequence of Bmp2 ablation. Microarray analysis demonstrates that ablation of Bmp2 leads to specific gene changes, including disruption of the Wnt signaling pathway, Progesterone receptor (PR) signaling, and the induction of prostaglandin synthase 2 (Ptgs2). Taken together, these data demonstrate that Bmp2 is a critical regulator of gene expression and function in the murine uterus.
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Cites
Model-based analysis of oligonucleotide arrays: Expression index computation and outlier detection.
Li, C., & Wong, W. H. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.1.31 · Cited by 3,133
Heads or tails: Wnts and anterior–posterior patterning
Yamaguchi, T. P. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00417-1 · Cited by 276
Cochaperone immunophilin FKBP52 is critical to uterine receptivity for embryo implantation
Tranguch, S., Cheung-Flynn, J., Daikoku, T., Prapapanich, V., Cox, M. B., Xie, H., Wang, H., Das, S. K., Smith, D. F., & Dey, S. K. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505775102 · Cited by 232
Barent, R. L., Nair, S. C., Carr, D. C., Ruan, Y., Rimerman, R. A., Fulton, J., Zhang, Y., & Smith, D. F. (1998) · Molecular Endocrinology · doi:10.1210/mend.12.3.0075 · Cited by 190 · cited 1×
“Fkbp4 and Fkbp5 have been shown to be a part of the molecular chaperone machinery that maintains hormone receptors in a functional state competent for binding hormone and transcriptional activation (2).”
BackgroundHubler, T. R., Denny, W. B., Valentine, D. L., Cheung-Flynn, J., Smith, D. F., & Scammell, J. G. (2003) · Endocrinology · doi:10.1210/en.2003-0092 · Cited by 145
Yang, Z., Wolf, I. M., Chen, H., Periyasamy, S., Chen, Z., Yong, W., Shi, S., Zhao, W., Xu, J., Srivastava, A., et al. (2006) · Molecular Endocrinology · doi:10.1210/me.2006-0024 · Cited by 119 · cited 2×
“The known functions of these genes, including interaction with histone deacetylases to alter gene transcription (64) and maintenance of functional hormone receptors (2, 23, 55, 65 ), suggests that these factors may be critical to appropriate, localized hormone action.”
Background
Cited by
Physiological and molecular determinants of embryo implantation
Zhang, S., Lin, H., Kong, S., Wang, S., Wang, H., Wang, H., & Armant, D. R. (2013) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2012.12.011 · Cited by 587
Jeong, J.-W., Lee, H. S., Franco, H. L., Broaddus, R. R., Taketo, M. M., Tsai, S. Y., Lydon, J. P., & DeMayo, F. J. (2009) · Oncogene · doi:10.1038/onc.2008.363 · Cited by 196
Self-citationThe Menstrual Cycle: Basic Biology
Hawkins, S. M., & Matzuk, M. M. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1429.018 · Cited by 168
Das, A., Mantena, S. R., Kannan, A., Evans, D. B., Bagchi, M. K., & Bagchi, I. C. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0901647106 · Cited by 131
Role of uterine stromal-epithelial crosstalk in embryo implantation
Hantak, A. M., Bagchi, I. C., & Bagchi, M. K. (2014) · The International Journal of Developmental Biology · doi:10.1387/ijdb.130348mb · Cited by 112
Metadata
- Authors
- Lee, K. Y., Jeong, J.-W., Wang, J., Ma, L., Martin, J. F., Tsai, S. Y., Lydon, J. P., & DeMayo, F. J.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 2007-08-01
- Volume
- 27
- Issue
- 15
- Pages
- 5468-5478
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W2139187815
- Cited by
- 350
- References
- 6
- FWCI
- 4.06
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Lee, K. Y., Jeong, J.-W., Wang, J., Ma, L., Martin, J. F., Tsai, S. Y., Lydon, J. P., & DeMayo, F. J. (2007). Bmp2 Is Critical for the Murine Uterine Decidual Response. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.00342-07
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