The DOI matches its Crossref record; 87 of the 87 references it cites were found in a registry or an index.
Hypoxia-Inducible Factor 1 and Dysregulated c-Myc Cooperatively Induce Vascular Endothelial Growth Factor and Metabolic Switches Hexokinase 2 and Pyruvate Dehydrogenase Kinase 1
Open accessAbstract
Hypoxia is a pervasive microenvironmental factor that affects normal development as well as tumor progression. In most normal cells, hypoxia stabilizes hypoxia-inducible transcription factors (HIFs), particularly HIF-1, which activates genes involved in anaerobic metabolism and angiogenesis. As hypoxia signals a cellular deprivation state, HIF-1 has also been reported to counter the activity of MYC, which encodes a transcription factor that drives cell growth and proliferation. Since many human cancers express dysregulated MYC, we sought to determine whether HIF-1 would in fact collaborate with dysregulated MYC rather countering its function. Here, using the P493-6 Burkitt's lymphoma model with an inducible MYC, we demonstrate that HIF-1 cooperates with dysregulated c-Myc to promote glycolysis by induction of hexokinase 2, which catalyzes the first step of glycolysis, and pyruvate dehydrogenase kinase 1, which inactivates pyruvate dehydrogenase and diminishes mitochondrial respiration. We also found the collaborative induction of vascular endothelial growth factor (VEGF) by HIF-1 and dysregulated c-Myc. This study reports the previously unsuspected collaboration between HIF-1 and dysregulated MYC and thereby provides additional insights into the regulation of VEGF and the Warburg effect, which describes the propensity for cancer cells to convert glucose to lactate.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“To preferentially engage aerobic glycolysis, cancer cells frequently co-opt several pathways, including the HIF/hypoxia transcriptional program, to enhance PDK1 expression and achieve PDHC repression (142).”
From Regulation and function of the mammalian tricarboxylic acid cycle (2023) · cites this paper as [142]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Hanahan, D., & Weinberg, R. A. (2000) · Cell · doi:10.1016/s0092-8674(00)81683-9 · Cited by 29,219
Warburg, O. (1956) · Science · doi:10.1126/science.123.3191.309 · Cited by 13,425
Targeting HIF-1 for cancer therapy
Semenza, G. L. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1187 · Cited by 6,717
Self-citationJaakkola, P., Mole, D. R., Tian, Y.-M., Wilson, M. I., Gielbert, J., Gaskell, S. J., Kriegsheim, A. V., Hebestreit, H. F., Mukherji, M., Schofield, C. J., et al. (2001) · Science · doi:10.1126/science.1059796 · Cited by 5,535
Why Do Cancers Have High Aerobic Glycolysis?
Gatenby, R. A., & Gillies, R. J. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1478 · Cited by 4,784
HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O 2 Sensing
Ivan, M., Kondo, K., Yang, H., Kim, W., Valiando, J., Ohh, M., Salic, A., Asara, J. M., Lane, W. S., & Kaelin Jr., W. G. (2001) · Science · doi:10.1126/science.1059817 · Cited by 4,735 · cited 1×
“Oxygen regulation of HIF-1 levels depends on the HIF-1 oxygen-dependent domain, which contains two prolyl residues (402 and 564), which are hydroxylated by prolyl hydroxylase in the presence of oxygen (4, 33 , 34, 52, 70, 73).”
BackgroundActivation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
Forsythe, J. A., Jiang, B.-H., Iyer, N. V., Agani, F., Leung, S. W., Koos, R. D., & Semenza, G. L. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.9.4604 · Cited by 3,981
Self-citationKim, J.-W., Tchernyshyov, I., Semenza, G. L., & Dang, C. V. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.02.002 · Cited by 3,905
Self-citationOn Respiratory Impairment in Cancer Cells
Warburg, O. H. (1956) · Science · doi:10.1126/science.124.3215.269 · Cited by 3,472
Regulation of angiogenesis by hypoxia: role of the HIF system
Pugh, C. W., & Ratcliffe, P. J. (2003) · Nature Medicine · doi:10.1038/nm0603-677 · Cited by 2,520
Flagged first, then by citations
Research works printed but not linked: 2
- Mateyak M. K., 1997, Cell Growth Differ., 8, 1039
- Mazure N. M., 2002, Cancer Res., 62, 1158
Cited by
Sorted by citations
Items 401–500 of 660
Impact of Hypoxia over Human Viral Infections and Key Cellular Processes
Reyes, A., Duarte, L. F., Farías, M. A., Tognarelli, E. I., Kalergis, A. M., Bueno, S. M., & González, P. A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22157954 · Cited by 25
Ubiquitin-specific protease 28: the decipherment of its dual roles in cancer development
Ren, X., Jiang, M., Ding, P., Zhang, X., Zhou, X. J., Shen, J., Liu, D., Yan, X., & Ma, Z. (2023) · Experimental Hematology and Oncology · doi:10.1186/s40164-023-00389-z · Cited by 25
Anticancer Effects of γ-Tocotrienol Are Associated with a Suppression in Aerobic Glycolysis
Parajuli, P., Tiwari, R. V., & Sylvester, P. W. (2015) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b15-00306 · Cited by 23
Barcelos, R. C., Pelizzaro‐Rocha, K. J., Pastre, J. C., Dias, M. P., Ferreira‐Halder, C. V., & Pilli, R. A. (2014) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2014.09.085 · Cited by 23
de Jonge, A. V., Mutis, T., Roemer, M. G. M., Scheijen, B., & Chamuleau, M. E. D. (2020) · Cancers · doi:10.3390/cancers12103052 · Cited by 25
Zhou, L., Zhan, M.-L., Tang, Y., Xiao, M., Li, M., Li, Q.-S., Yang, L., Li, X., Chen, W.-W., & Wang, Y.-L. (2018) · International Journal of Oncology · doi:10.3892/ijo.2018.4506 · Cited by 22
Molecular and Metabolic Subtypes in Sporadic and Inherited Clear Cell Renal Cell Carcinoma
Czyzyk-Krzeska, M., Figueroa, J. A. L., Gulati, S., Cunningham, J. T., Meller, J., Shamsaei, B., Vemuri, B., & Plas, D. R. (2021) · Genes · doi:10.3390/genes12030388 · Cited by 23
Metabolic reprogramming directed by super-enhancers in tumors: An emerging landscape
Zhou, Z., Li, J., Ousmane, D., Peng, L., Yuan, X., & Wang, J. (2024) · Molecular Therapy · doi:10.1016/j.ymthe.2024.02.003 · Cited by 22
Yanagawa, M., Morii, E., Hata, A., Fujiwara, M., Gyobu, T., Ueda, K., Honda, O., & Tomiyama, N. (2016) · European Journal of Radiology · doi:10.1016/j.ejrad.2016.05.016 · Cited by 21
Tip of the Iceberg: Roles of CircRNAs in Cancer Glycolysis
Tan, L., Xian, H.-C., Dai, L., Tang, Y., & Liang, X. (2021) · OncoTargets and Therapy · doi:10.2147/ott.s297140 · Cited by 21
Mu, H., Ge, Y. P., Li, H., Wang, M., Cui, Y., Zhang, T., Song, T., & Liu, C. (2021) · Cellular Oncology · doi:10.1007/s13402-021-00625-w · Cited by 23
Aprile, M., Cataldi, S., Perfetto, C., Federico, A., Ciccodicola, A., & Costa, V. (2023) · British Journal of Cancer · doi:10.1038/s41416-023-02282-2 · Cited by 21
Yang, K., Zhong, Z., Zou, J., Liao, J., Chen, S., Zhou, S., Zhao, Y., Li, J., Yin, D., Huang, K., et al. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.216840 · Cited by 21
Guo, C. Y., & Palmer, A. F. (2010) · Tissue Engineering Part A · doi:10.1089/ten.tea.2010.0058 · Cited by 21
Wu, H., Yang, J., Yang, Z., Xiao, Y., Liu, R., Jia, J., Zhang, X., Zhang, Y., Fu, Z., Yao, Z., et al. (2025) · Cell Death and Differentiation · doi:10.1038/s41418-025-01531-6 · Cited by 20
Guddeti, R. K., Thomas, L., Kannan, A., Karyala, P., & Pakala, S. B. (2021) · FEBS Letters · doi:10.1002/1873-3468.14062 · Cited by 20
Hua, Q., Mi, B., & Huang, G. (2018) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2018.03.028 · Cited by 20
Lu, J., Liang, X., Gao, Y., Fu, G., & Shen, Q. (2019) · Journal of Cellular Biochemistry · doi:10.1002/jcb.29278 · Cited by 20
Avenues of research in dietary interventions to target tumor metabolism in osteosarcoma
Leite, T. C., Watters, R. J., Weiss, K. R., & Intini, G. (2021) · Journal of Translational Medicine · doi:10.1186/s12967-021-03122-8 · Cited by 21
Zhao, C., Isenberg, J. S., & Popel, A. S. (2017) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1005272 · Cited by 19
EZH2, HIF-1, and Their Inhibitors: An Overview on Pediatric Cancers
Papale, M., Ferretti, E., Battaglia, G., Bellavia, D., Mai, A., & Tafani, M. (2018) · Frontiers in Pediatrics · doi:10.3389/fped.2018.00328 · Cited by 19
Yang, E.-S., Do, Y., Cheon, S.-Y., Kim, B., Ling, J., Cho, M., Kim, T., Bae, S., & Ha, K. (2023) · Oncology Reports · doi:10.3892/or.2023.8509 · Cited by 19
Chen, Y., Zhu, H., Luo, Y., Xie, T., Hu, Y., Yan, Z., Ji, W., Wang, Y., Yin, Q., & Xian, H. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1573815 · Cited by 19
McDonald, T. S., & Borges, K. (2017) · Epilepsia · doi:10.1111/epi.13796 · Cited by 19
Li, X., & Xu, W. (2019) · Oncology Reports · doi:10.3892/or.2019.7041 · Cited by 19
Kou, L., Wei, S., & Kou, P. (2021) · Frontiers in Chemistry · doi:10.3389/fchem.2021.733463 · Cited by 19
Cevatemre, B., Ulukaya, E., Dere, E., Dilege, Ş., & Açılan, C. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.738916 · Cited by 19
Cardiovascular Dysfunction in COVID-19: Association Between Endothelial Cell Injury and Lactate
Yang, K., Holt, M., Fan, M., Lam, V. L., Yang, Y., Ha, T., Williams, D. L., Li, C., & Wang, X. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.868679 · Cited by 19
Hypoxia-inducible factor-2α regulates the expression of TRAIL receptor DR5 in renal cancer cells
Mahajan, S., Dammai, V., Hsu, T., & Kraft, A. S. (2008) · Carcinogenesis · doi:10.1093/carcin/bgn132 · Cited by 20
Autophagy in Viral Development and Progression of Cancer
Suares, A., Medina, M. V., & Coso, O. A. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.603224 · Cited by 19
Li, J., Fang, Y. H., & Wu, D. (2021) · Current topics in membranes · doi:10.1016/bs.ctm.2021.07.003 · Cited by 19
Hypoxia-Induced LXRα Contributes to the Migration and Invasion of Gastric Cancer Cells
Guo, R., & Yang, B. J. (2021) · Folia Biologica · doi:10.14712/fb2021067030091 · Cited by 18
Curcumin and Wnt/β‑catenin signaling in exudative age‑related macular degeneration (Review)
Vallée, A. (2022) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2022.5135 · Cited by 18
Harshan, S., Dey, P., & Raghunathan, S. (2022) · Genes · doi:10.3390/genes13071216 · Cited by 17
Adhikari, S., Guha, D., Mohan, C., Mukherjee, S., Tyler, J. K., & Das, C. (2022) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-3-031-07634-3_1 · Cited by 19
Mitochondrial dynamics and metabolism in induced pluripotency
Prieto, J., Ponsoda, X., Belmonte, J. C. I., & Torres, J. (2020) · Experimental Gerontology · doi:10.1016/j.exger.2020.110870 · Cited by 18
Bornlisy Attenuates Colitis-Associated Colorectal Cancer via Inhibiting GPR43-Mediated Glycolysis
Lu, X., Qiao, S., Chen, P., Yan, W., Xu, Z., Qu, J., Hou, Y., Zhao, S., Chen, P., & Wang, T. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.706382 · Cited by 17
Nagasaka, M., Inoue, Y., Yoshida, M., Miyajima, C., Morishita, D., Tokugawa, M., Nakamoto, H., Sugano, M., Ohoka, N., & Hayashi, H. (2022) · FEBS Letters · doi:10.1002/1873-3468.14296 · Cited by 17
Dual Targeting Oncoproteins MYC and HIF1α Regresses Tumor Growth of Lung Cancer and Lymphoma
Huang, X., Liu, Y., Wang, Y., Bailey, C., Zheng, P., & Liu, Y. (2021) · Cancers · doi:10.3390/cancers13040694 · Cited by 17
Self-citationDuan, R., Zhai, Y., Wang, Q., Zhao, L., Wang, Y., Yu, N., Zhang, J., & Guo, W. (2024) · MedComm · doi:10.1002/mco2.70003 · Cited by 16
Dasgupta, A., Sawant, M. A., Lavhale, M. S., Krishnapati, L. S., Ghaskadbi, S., & Sitasawad, S. L. (2015) · Angiogenesis · doi:10.1007/s10456-015-9466-5 · Cited by 16
Metabolic pathways in cancers: key targets and implications in cancer therapy
Vijayakumar, S. N., Sethuraman, S., & Krishnan, U. M. (2015) · RSC Advances · doi:10.1039/c5ra06505d · Cited by 16
Antino, M., Gil-Rodríguez, F., Rodríguez‐Muñoz, A., & Borzillo, S. (2014) · International Journal of Social Psychology Revista de Psicología Social · doi:10.1080/02134748.2014.972705 · Cited by 16
SIRT6 regulated nucleosomal occupancy affects Hexokinase 2 expression
Gupta, P., Sheikh, T., & Sen, E. (2017) · Experimental Cell Research · doi:10.1016/j.yexcr.2017.05.005 · Cited by 16
Maurer, G. D., Brucker, D. P., & Steinbach, J. P. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.05.115 · Cited by 16
The expanding universe of hypoxia
Zhang, H., & Semenza, G. L. (2008) · Journal of Molecular Medicine · doi:10.1007/s00109-008-0364-9 · Cited by 17
Self-citationZou, Y., Wang, R., Zhao, J., Cai, Y., & Zhong, W. (2021) · American Journal Of Pathology · doi:10.1016/j.ajpath.2021.02.010 · Cited by 15
Advances in Understanding of Metabolism of B-Cell Lymphoma: Implications for Therapy
Kľučková, K., D’Avola, A., & Riches, J. C. (2022) · Cancers · doi:10.3390/cancers14225552 · Cited by 16
Yazdani, B., Sirous, H., Enguita, F. J., Brogi, S., Wing, P. A. C., & Fassihi, A. (2023) · Molecular Diversity · doi:10.1007/s11030-023-10650-6 · Cited by 16
CK1δ and CK1ε Signaling Sustains Mitochondrial Metabolism and Cell Survival in Multiple Myeloma
Burger, K. L., Fernandez, M. R., Meads, M. B., Sudalagunta, P. R., Oliveira, P. S., Canevarolo, R. R., Alugubelli, R. R., Tungsevik, A., Avila, G. D., SILVA, M. R. N. G., et al. (2023) · Cancer Research · doi:10.1158/0008-5472.can-22-2350 · Cited by 15
Fernández-Calero, T., Davyt, M., Perelmuter, K., Chalar, C., Bampi, G., Persson, H., Tosar, J. P., Hafstað, V., Naya, H., Rovira, C., et al. (2020) · Cancer & Metabolism · doi:10.1186/s40170-020-00216-7 · Cited by 18
Non-coding RNAs, metabolic stress and adaptive mechanisms in cancer
Liu, X., Feng, S., Zhang, X. D., Li, J., Zhang, K., Wu, M., & Thorne, R. F. (2020) · Cancer Letters · doi:10.1016/j.canlet.2020.06.024 · Cited by 15
Miripour, Z. S., Abbasvandi, F., Aghaee, P., Najafikhoshnoo, S., Faramarzpour, M., Mohaghegh, P., Hoseinpour, P., Namdar, N., Amiri, M. H., Ghafari, H., et al. (2021) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10236 · Cited by 15
Micronutrient Food Supplements in Patients with Gastro-Intestinal and Hepatic Cancers
Alam, W., Ullah, H., Santarcangelo, C., Minno, A. D., Khan, H. Z., Daglia, M., & Arciola, C. R. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22158014 · Cited by 15
Dendelé, B., Tekpli, X., Sergent, O., Dimanche‐Boitrel, M., Holme, J. A., Laurence Therese, H. U. C., & Lagadic‐Gossmann, D. (2011) · Toxicology in Vitro · doi:10.1016/j.tiv.2011.11.001 · Cited by 15
Shi, W., Xu, X., Yan, F., Wang, B., Zhao, H., Chan, A., Ren, Z., Ma, Y., Wang, F., & Yuan, J. (2017) · Oncology Letters · doi:10.3892/ol.2017.7024 · Cited by 15
Oncogenic kinases and perturbations in protein synthesis machinery and energetics in neoplasia
Uchenunu, O., Pollak, M., Topisirović, I., & Hulea, L. (2018) · Journal of Molecular Endocrinology · doi:10.1530/jme-18-0058 · Cited by 16
Non-Hodgkin Lymphoma Metabolism
Kirsch, B. J., Chang, S., Betenbaugh, M. J., & Le, A. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-65768-0_7 · Cited by 17
GLUT1 as a Potential Therapeutic Target in Glioblastoma
Ruchika, F., Suvarnapathaki, S., Serrano-Farias, A., Bettegowda, C., & Rincón-Torroella, J. (2025) · Brain Sciences · doi:10.3390/brainsci15060585 · Cited by 14
Paradoski, B. T., Hou, S., Mejia, E. M., Olayinka‐Adefemi, F., Fowke, D., Hatch, G. M., Saleem, A., Banerji, V., Hay, N., Zeng, H., et al. (2024) · iScience · doi:10.1016/j.isci.2024.110939 · Cited by 14
Geranylgeranyltransferase I regulates HIF-1α promoting glioblastoma cell migration and invasion
Zhou, X., Liu, Z., Shi, Q., Jiao, J., Bian, W., Song, X., Mo, J., Sang, B., Xu, Y., Qian, J., et al. (2013) · Journal of Neuro-Oncology · doi:10.1007/s11060-013-1081-y · Cited by 15
Liu, X., Tan, X., Xia, M., Wu, C., Song, J., Wu, J., Laurence, A. D. J., Xie, Q., Zhang, M., Liang, H., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.6661 · Cited by 14
Recent advances in understanding lymphangiogenesis and metabolism
Lee, H., Yu, P., & Simons, M. (2018) · F1000Research · doi:10.12688/f1000research.14803.1 · Cited by 14
Wang, L., Wang, H., Wu, B., Zhang, C., Yu, H., Li, X., Wang, Q., Shi, X., Fan, C., Wang, D., et al. (2020) · OncoTargets and Therapy · doi:10.2147/ott.s273797 · Cited by 14
Purkayastha, B. P. D., & Roy, J. K. (2014) · Cancer Letters · doi:10.1016/j.canlet.2014.05.015 · Cited by 14
TNFα driven HIF-1α-hexokinase II axis regulates MHC-I cluster stability through actin cytoskeleton
Ghosh, S., Gupta, P., & Sen, E. (2015) · Experimental Cell Research · doi:10.1016/j.yexcr.2015.11.016 · Cited by 14
Kocemba‐Pilarczyk, K. A., Dulińska-Litewka, J., Wojdyła, K. L., & Pękala, P. A. (2016) · Postępy Higieny i Medycyny Doświadczalnej · doi:10.5604/17322693.1218187 · Cited by 14
Metabolic Gatekeepers of Pathological B Cell Activation
Sadras, T., Chan, L. N., Xiao, G., & Müschen, M. (2020) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-061020-050135 · Cited by 17
Lactylation: a novel driver of drug resistance in the tumor microenvironment
Li, C., Liu, Z., Kong, D., Li, Z., & Li, L. (2025) · Cancer Drug Resistance · doi:10.20517/cdr.2025.90 · Cited by 13
FKBP4 promotes glycolysis and hepatocellular carcinoma progression via p53/HK2 axis
Zeng, Z., Xu, S., Wang, R., & Han, X. (2024) · Scientific Reports · doi:10.1038/s41598-024-78383-6 · Cited by 13
Wang, L., Shi, M., Sung, A. Y., Yin, C. C., Bai, Y., & Chen, M. (2025) · Seminars in Diagnostic Pathology · doi:10.1016/j.semdp.2025.150916 · Cited by 14
Cofilin Acts as a Booster for Progression of Malignant Tumors Represented by Glioma
Lv, S., Chen, Z., Mi, H., & Yu, X. (2022) · Cancer Management and Research · doi:10.2147/cmar.s389825 · Cited by 14
Active pyruvate dehydrogenase and impaired gluconeogenesis in orthotopic hepatomas of rats
Lee, M. H., DeBerardinis, R. J., Wen, X., Corbin, I. R., Sherry, A. D., Malloy, C. R., & Jin, E. S. (2019) · Metabolism · doi:10.1016/j.metabol.2019.153993 · Cited by 13
Circular RNAs Regulate Glucose Metabolism in Cancer Cells
Ji, X., Sun, W., Lv, C., Huang, J., & Zhang, H. (2021) · OncoTargets and Therapy · doi:10.2147/ott.s316597 · Cited by 13
Guo, J., Wang, C., Tang, H., Sang, B., Liu, X., Yi, F., & Wu, X. (2022) · Cell Biology International · doi:10.1002/cbin.11780 · Cited by 13
Liu, Y., Guo, F.-M., Qiu, W.-J., Gao, Y.-P., Han, X., & Shen, B. (2025) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd12100384 · Cited by 14
Self-citationShifting the Gears of Metabolic Plasticity to Drive Cell State Transitions in Cancer
Wu, Z., Lee, Y. F., Yeo, X. H., Loo, S. Y., & Tam, W. L. (2021) · Cancers · doi:10.3390/cancers13061316 · Cited by 14
Łuczak, M. W., Krawic, C., & Zhitkovich, A. (2021) · Cell Cycle · doi:10.1080/15384101.2021.1959988 · Cited by 12
Stabilization of PIM Kinases in Hypoxia Is Mediated by the Deubiquitinase USP28
Toth, R. K., Solomon, R. N., & Warfel, N. A. (2022) · Cells · doi:10.3390/cells11061006 · Cited by 12
Elongation factor 1A1 regulates metabolic substrate preference in mammalian cells
Wilson, R. B., Kozlov, A. M., Tehrani, H. H., Twumasi-Ankrah, J. S., Chen, Y. J., Borrelli, M. J., Sawyez, C. G., Maini, S., Shepherd, T. G., Cumming, R. C., et al. (2024) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2024.105684 · Cited by 12
Vallée, A., Lecarpentier, Y., & Vallée, J.-N. (2021) · Biomedicines · doi:10.3390/biomedicines9060619 · Cited by 12
Wobser, M., Siedel, C., Kneitz, H., Br�cker, E.-B., Goebeler, M., Houben, R., & Geissinger, E. (2013) · Acta Dermato Venereologica · doi:10.2340/00015555-1589 · Cited by 12
Identification of pyruvate dehydrogenase kinase 1 inhibitors with anti-osteosarcoma activity
Fang, A., Luo, H., Liu, L., Fan, H., Zhou, Y., Yao, Y., & Zhang, Y. (2017) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2017.10.073 · Cited by 12
Colella, F., Calapà, F., Artemi, G., Pazzaglia, E., Colonna, R., Vitale, S., Lazzarino, G., Vincenzoni, F., Fiori, M. E., Maria, R. D., et al. (2025) · Journal of Extracellular Biology · doi:10.1002/jex2.70039 · Cited by 11
Jiang, Y., Peng, F., Chen, Y., Fu, A., Yang, R., Yang, Z., Wang, Q., & Cao, L. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-08033-w · Cited by 10
Clutton, G., Weideman, A. M., Goonetilleke, N. P., & Maurer, T. A. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.961021 · Cited by 10
Shutting off the fuel supply to target metabolic vulnerabilities in multiple myeloma
Rana, P. S., Goparaju, K., & Driscoll, J. J. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1141851 · Cited by 10
The Role of Kallikrein 7 in Tumorigenesis
Xiang, F., Wang, Y., Cao, C., Li, Q., Deng, H., Zheng, J., Liu, X., & Tan, X. (2021) · Current Medicinal Chemistry · doi:10.2174/0929867328666210915104537 · Cited by 10
Jin, X., Shao, X., Pang, W., Wang, Z., & Huang, J. (2022) · Bioengineered · doi:10.1080/21655979.2022.2073127 · Cited by 10
Vulic, R., Zdurienčíková, M., Tyčiaková, S., Benada, O., Dubrovčáková, M., Lakota, J., & Škultéty, Ľ. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14265 · Cited by 10
Ferdousmakan, S., Mansourian, D., Asl, F. S. S., Fathi, Z., Maleki‐Sheikhabadi, F., Nabi‐Afjadi, M., & Zalpoor, H. (2025) · Medical Oncology · doi:10.1007/s12032-025-02607-6 · Cited by 9
Labrecque, M. P., Brown, L. G., Coleman, I. M., Nguyen, H. M., Lin, D. W., Corey, E., Nelson, P. S., & Morrissey, C. M. (2021) · PLoS ONE · doi:10.1371/journal.pone.0245602 · Cited by 9
Exploring Myc puzzle: Insights into cancer, stem cell biology, and PPI networks
Ghasemi, N., & Azizi, H. (2024) · Gene · doi:10.1016/j.gene.2024.148447 · Cited by 9
Varlı, M., Kim, E., Oh, S., Pulat, S., Zhou, R., Gamage, C. D. B., Gökalsın, B., Sesal, N. C., Kim, K. K., Paik, M., et al. (2024) · Cancer Cell International · doi:10.1186/s12935-024-03434-x · Cited by 9
Prakasam, G., Iqbal, M. A., Srivastava, A., Bamezai, R. N. K., & Singh, R. K. (2022) · VirusDisease · doi:10.1007/s13337-022-00776-w · Cited by 8
Signaling pathways driving ocular malignancies and their targeting by bioactive phytochemicals
Croley, C. R., Pumarol, J., Delgadillo, B. E., Cook, A. C., Day, F., Kaceli, T., Ward, C. C., Husain, I., Husain, A., Banerjee, S., et al. (2023) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2023.108479 · Cited by 8
Jin, X., Ji, T., Shi, Z., Zhang, Q., Ye, F., Yu, W., & Li, R. (2021) · The Kaohsiung Journal of Medical Sciences · doi:10.1002/kjm2.12399 · Cited by 8
Targeting Cancer Metabolism to Improve Outcomes with Immune Checkpoint Inhibitors
Fatima, Z., Abonofal, A., & Stephen, B. (2023) · Journal of Immunotherapy and Precision Oncology · doi:10.36401/jipo-22-27 · Cited by 9
BioVyon Protein A, an alternative solid-phase affinity matrix for chromatin immunoprecipitation
Chernukhin, I. V., Kang, S. Y., Brown, S., Gretton, S., Méndez-Catalá, C. F., Cowieson, D., & Klenova, E. M. (2011) · Analytical Biochemistry · doi:10.1016/j.ab.2011.01.036 · Cited by 8
Racial disparity in metabolic regulation of cancer
Singh, P. K. (2017) · Frontiers in bioscience · doi:10.2741/4543 · Cited by 8
Metadata
- Authors
- Kim, J.-W., Gao, P., Liu, Y.-C., Semenza, G. L., & Dang, C. V.
- Affiliations
- Division of Hematology, Department of Medicine
- Graduate Program of Pathobiology
- Johns Hopkins University (US)
- Corresponding author
- Dang, Chi V.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 2007-11-01
- Volume
- 27
- Issue
- 21
- Pages
- 7381-7393
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- PMC
- PMC2169056
- OpenAlex
- W2105250121
- Cited by
- 658
- References
- 87
- Citations by year
- 2026: 21 · 2025: 29 · 2024: 28 · 2023: 31 · 2022: 49 · 2021: 60 · 2020: 45 · 2019: 48 · 2018: 38 · 2017: 36 · 2016: 38 · 2015: 28 · 2014: 44 · 2013: 29 · 2012: 35
- FWCI
- 8.37
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Molecular and Cellular Biology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Johns Hopkins University
- National Institutes of Health (n01hv28180-13-0-0, NO1-HV-28180)
- National Heart, Lung, and Blood Institute (N01 HV028180, N02-HV-28180)
- National Cancer Institute (CA 57341, R01CA057341, CA52497)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Kruppel-like factors research
- Keywords
- HIF-1, c-Myc, vascular endothelial growth factor, hexokinase 2, pyruvate dehydrogenase kinase 1, Warburg effect, glycolysis, mitochondrial respiration, Burkitt lymphoma, tumor hypoxia, angiogenesis, cancer metabolism
- MeSH terms
- Pyruvate Dehydrogenase Acetyl-Transferring Kinase, Cell Line, DNA, Enzyme Induction, Glucose, Glycolysis, Hexokinase, Humans, Neoplasms, Protein Binding, Regulatory Sequences, Nucleic Acid, Proto-Oncogene Proteins c-myc, Protein Serine-Threonine Kinases, Vascular Endothelial Growth Factor A, Chromatin Immunoprecipitation, Hypoxia-Inducible Factor 1
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review