Cited by 660Cancer, Hypoxia, and MetabolismAngiogenesis and VEGF in CancerKruppel-like factors research

The DOI matches its Crossref record; 87 of the 87 references it cites were found in a registry or an index.

Hypoxia-Inducible Factor 1 and Dysregulated c-Myc Cooperatively Induce Vascular Endothelial Growth Factor and Metabolic Switches Hexokinase 2 and Pyruvate Dehydrogenase Kinase 1

Open access

Kim, Jung-whan, Gao, Ping, Liu, Yen-Chun, Semenza, Gregg L., Dang, Chi V.·2007·Molecular and Cellular Biology

Open this paper in CoChat — free account

Abstract

Hypoxia is a pervasive microenvironmental factor that affects normal development as well as tumor progression. In most normal cells, hypoxia stabilizes hypoxia-inducible transcription factors (HIFs), particularly HIF-1, which activates genes involved in anaerobic metabolism and angiogenesis. As hypoxia signals a cellular deprivation state, HIF-1 has also been reported to counter the activity of MYC, which encodes a transcription factor that drives cell growth and proliferation. Since many human cancers express dysregulated MYC, we sought to determine whether HIF-1 would in fact collaborate with dysregulated MYC rather countering its function. Here, using the P493-6 Burkitt's lymphoma model with an inducible MYC, we demonstrate that HIF-1 cooperates with dysregulated c-Myc to promote glycolysis by induction of hexokinase 2, which catalyzes the first step of glycolysis, and pyruvate dehydrogenase kinase 1, which inactivates pyruvate dehydrogenase and diminishes mitochondrial respiration. We also found the collaborative induction of vascular endothelial growth factor (VEGF) by HIF-1 and dysregulated c-Myc. This study reports the previously unsuspected collaboration between HIF-1 and dysregulated MYC and thereby provides additional insights into the regulation of VEGF and the Warburg effect, which describes the propensity for cancer cells to convert glucose to lactate.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1128/mcb.00440-07

Cites

87 of 87 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The hallmarks of cancer
Hanahan, D., & Weinberg, R. A. (2000) · Cell · doi:10.1016/s0092-8674(00)81683-9 · Cited by 29,219
On the origin of cancer cells
Warburg, O. (1956) · Science · doi:10.1126/science.123.3191.309 · Cited by 13,425
Targeting HIF-1 for cancer therapy
Semenza, G. L. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1187 · Cited by 6,717
Self-citation
Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O 2 -Regulated Prolyl Hydroxylation
Jaakkola, P., Mole, D. R., Tian, Y.-M., Wilson, M. I., Gielbert, J., Gaskell, S. J., Kriegsheim, A. V., Hebestreit, H. F., Mukherji, M., Schofield, C. J., et al. (2001) · Science · doi:10.1126/science.1059796 · Cited by 5,535
Why Do Cancers Have High Aerobic Glycolysis?
Gatenby, R. A., & Gillies, R. J. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1478 · Cited by 4,784
HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O 2 Sensing
Ivan, M., Kondo, K., Yang, H., Kim, W., Valiando, J., Ohh, M., Salic, A., Asara, J. M., Lane, W. S., & Kaelin Jr., W. G. (2001) · Science · doi:10.1126/science.1059817 · Cited by 4,735 · cited 1×
“Oxygen regulation of HIF-1 levels depends on the HIF-1 oxygen-dependent domain, which contains two prolyl residues (402 and 564), which are hydroxylated by prolyl hydroxylase in the presence of oxygen (4, 33 , 34, 52, 70, 73).”
Background
Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
Forsythe, J. A., Jiang, B.-H., Iyer, N. V., Agani, F., Leung, S. W., Koos, R. D., & Semenza, G. L. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.9.4604 · Cited by 3,981
Self-citation
HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
Kim, J.-W., Tchernyshyov, I., Semenza, G. L., & Dang, C. V. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.02.002 · Cited by 3,905
Self-citation
On Respiratory Impairment in Cancer Cells
Warburg, O. H. (1956) · Science · doi:10.1126/science.124.3215.269 · Cited by 3,472
Regulation of angiogenesis by hypoxia: role of the HIF system
Pugh, C. W., & Ratcliffe, P. J. (2003) · Nature Medicine · doi:10.1038/nm0603-677 · Cited by 2,520

Flagged first, then by citations

Show all 87 references

Research works printed but not linked: 2

Mateyak M. K., 1997, Cell Growth Differ., 8, 1039
Mazure N. M., 2002, Cancer Res., 62, 1158

Sorted by citations

Items 601–660 of 660

Análise de proteômica do microambiente tumoral de pacientes caquéticos: desvendando vias biológicas e mecanismos moleculares na caquexia.
Lima, J. D. C. C. (2020) · doi:10.11606/t.42.2020.tde-06012021-095737
Mild Chronic Hypoxia-Induced HIF-2α Interacts with c-MYC Through Competition with HIF-1α in Hepatocellular Carcinoma ProliferationPreprint
Mu, H., Yu, G., Li, H., Wang, M., Cui, Y., Zhang, T., Song, T., & Liu, C. (2020) · doi:10.21203/rs.3.rs-37458/v1
Erratum to: The 2014 Beatson international cancer conference: powering the cancer machine
Kamphorst, J. J., & Murphy, D. J. (2014) · Cancer & Metabolism · doi:10.1186/s40170-014-0127-8
Nutraceuticals for Prevention and Treatment of Cancer
Das, N., Nathani, S., Kumar, V., Agrawal, H., Sircar, D., & Roy, P. (2022) · Wiley eBooks · doi:10.1002/9781119746843.ch19
Metabolic Reprogramming of Circulating Tumor Cells for Metastasis
Zhang, Z., & Shi, Q. (2022) · Springer eBooks · doi:10.1007/978-3-030-93084-4_18
Targeting the Immuno-Oncology Metabolism in Cancer
Tripathi, S. C., Fahrmann, J. F., & Amle, D. B. (2022) · Springer eBooks · doi:10.1007/978-981-16-6226-3_5
Data from Combinatorial Regulation of Neuroblastoma Tumor Progression by N-Myc and Hypoxia Inducible Factor HIF-1α
Qing, G., Skuli, N., Mayes, P. A., Pawel, B., Martı́nez, D., Maris, J. M., & Simon, M. C. (2023) · doi:10.1158/0008-5472.c.6500883
Supplementary Figure 4 from Hyperpolarized 13C Spectroscopic Imaging Informs on Hypoxia-Inducible Factor-1 and Myc Activity Downstream of Platelet-Derived Growth Factor Receptor
Dafni, H., Larson, P. E. Z., Hu, S., Yoshihara, H. A. I., Ward, C. S., Venkatesh, H. S., Wang, C., Zhang, X., Vigneron, D. B., & Ronen, S. M. (2023) · doi:10.1158/0008-5472.22385141
Data from PPARα Agonist Fenofibrate Enhances Cancer Vaccine Efficacy
Chekaoui, A., & Ertl, H. C. J. (2023) · doi:10.1158/0008-5472.c.6513286.v1
Ancient Synteny Links Metabolism with Erythroid DevelopmentPreprint
Preston, A. E., Frost, J. N., Badat, M., Teh, M. R., Armitage, A. E., Norfo, R., Wideman, S. K., Hanifi, M., White, N., Roy, N. B. A., et al. (2023) · SSRN Electronic Journal · doi:10.2139/ssrn.4615452
Hypoxia and Epithelial-to-Mesenchymal Transition (EMT) in Cancer: A Non-coding RNA Perspective
Singh, A., Gupta, R., & Kulshreshtha, R. (2023) · RNA technologies · doi:10.1007/978-3-031-36390-0_21
Additional file 6 of Natural product triptolide induces GSDME-mediated pyroptosis in head and neck cancer through suppressing mitochondrial hexokinase-ΙΙ
Cai, J., Yi, M., Tan, Y., Li, X., Li, G., Zeng, Z., Xiong, W., & Xiang, B. (2021) · Figshare · doi:10.6084/m9.figshare.14759595
Regulation of glycolysis in bladder cancer
Pandey, P. K., Shrivastava, A., Srivastava, A., Jain, A., Venkatesh, V., Tiwari, S., Singh, R. K., & Jamal, F. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-23881-9.00003-7
Effects of Extracellular pH Modulation on HIF-1α, c-Myc, and FOXO1 Expression in Colorectal Cancer Cells
Ibrahim, S., Rifai, F. N. P., & Arda, A. G. (2025) · International Journal of Cell and Biomedical Science · doi:10.59278/cbs.v4i10.67
Multidimensional Single-Cell Transcriptomic Profiling of Uterine Leiomyosarcomas Reveals Distinct Tumor States with Inferred Therapeutic VulnerabilitiesPreprint
Korah, M. M., Agolia, J. P., Reddy, B., Flojo, R. A. B., Gonçalves, A. C., Wang, L., Bethi, R., Bobst, W., Liang, B., Yip, K. A., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.11.17.688894
The study of RAS-induced metabolic reprogramming and the role of the pentose phosphate pathway in tumor metabolism
Mauricio, A. B. (2014) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
Characterization of the Role of Mitochondrial Function During Tumor Development and Muscle Wasting
Wang, X. (2012)
Additional file 1 of Natural product triptolide induces GSDME-mediated pyroptosis in head and neck cancer through suppressing mitochondrial hexokinase-ΙΙ
Cai, J., Yi, M., Tan, Y., Li, X., Li, G., Zeng, Z., Xiong, W., & Xiang, B. (2021) · Figshare · doi:10.6084/m9.figshare.14759580
Additional file 3 of Natural product triptolide induces GSDME-mediated pyroptosis in head and neck cancer through suppressing mitochondrial hexokinase-ΙΙ
Cai, J., Yi, M., Tan, Y., Li, X., Li, G., Zeng, Z., Xiong, W., & Xiang, B. (2021) · Figshare · doi:10.6084/m9.figshare.14759586
Additional file 4 of Natural product triptolide induces GSDME-mediated pyroptosis in head and neck cancer through suppressing mitochondrial hexokinase-ΙΙ
Cai, J., Yi, M., Tan, Y., Li, X., Li, G., Zeng, Z., Xiong, W., & Xiang, B. (2021) · Figshare · doi:10.6084/m9.figshare.14759589
Additional file 1 of A review of the biological and clinical implications of RAS-MAPK pathway alterations in neuroblastoma
Mlakar, V., Morel, E., Mlakar, S. J., Ansari, M., & Gumy‐Pause, F. (2021) · Figshare · doi:10.6084/m9.figshare.14752291
Additional file 5 of Natural product triptolide induces GSDME-mediated pyroptosis in head and neck cancer through suppressing mitochondrial hexokinase-ΙΙ
Cai, J., Yi, M., Tan, Y., Li, X., Li, G., Zeng, Z., Xiong, W., & Xiang, B. (2021) · Figshare · doi:10.6084/m9.figshare.14759592
Additional file 2 of Natural product triptolide induces GSDME-mediated pyroptosis in head and neck cancer through suppressing mitochondrial hexokinase-ΙΙ
Cai, J., Yi, M., Tan, Y., Li, X., Li, G., Zeng, Z., Xiong, W., & Xiang, B. (2021) · Figshare · doi:10.6084/m9.figshare.14759583
Additional file 1 of Proton export upregulates aerobic glycolysis
Russell, S., Xu, L., Kam, Y., Abrahams, D., Ordway, B., Lopez, A. S., Bui, M. M., Johnson, J., Epstein, T., Ruiz, E., et al. (2022) · Figshare · doi:10.6084/m9.figshare.20324710
MiR-181a-5p/CDK6 axis attenuates cell proliferation, migration and glycolytic reprogramming in oral squamous cell carcinoma
Gao, J., Yang, Y., Chang, X., Wang, X., Zhang, Z., Shi, S., Liu, Y., Su, J., Chen, Z., Sun, R., et al. (2026) · Cancer Cell International · doi:10.1186/s12935-026-04171-z
Self-citation
Molecular mechanisms and targeted therapeutic strategies for glycolytic reprogramming in osteosarcoma
Ni, X., Xia, P., Liang, M., Zhang, L. Q., Chen, J., He, Z., Huang, H., Feng, J., Niu, X., & Pu, F. (2026) · Genes & Diseases · doi:10.1016/j.gendis.2026.102111
Métabolisme oxydatif et mitochondrial des cellules cancéreuses de prostate
Matar, C. (2011) · theses.fr (ABES) · doi:10.70675/6abb943ez119bz424fzbe51z3467241fc235
Metabolic fueling of hematopoietic stem cell differentiation to the erythroid lineage
Oburoglu, L. (2014) · theses.fr (ABES) · doi:10.70675/2a8ca582z1bd3z4b90z96c1z5964d1e426b9
Etude de la reprogrammation métabolique de l' adénocarcinome canalaire pancréatique
Olivares, O. (2015) · theses.fr (ABES) · doi:10.70675/ef2c6a2czab6dz4a68z8004z1ade8605dadc
Molecular thermodynamic aspects of dissipative structures in oncology, inflammatory and degenerative processes of Central Nervous System diseases
Vallée, A. (2017) · theses.fr (ABES) · doi:10.70675/e07edff7z4f56z4165z8ee2z475c4aafb600
Étude de l’effet Warburg, à l’origine du métabolisme énergétique de la cellule cancéreuse, chez la levure Saccharomyces cerevisiae
Hammad, N. (2018) · theses.fr (ABES) · doi:10.70675/95e12429zc05bz4cd1za56ez80e5989decee
Identification of APOBEC-Associated Frequent Mutations and Characterization of FGFR3-Driven Signaling Pathways in Bladder Cancer
Shi, M. (2019) · theses.fr (ABES) · doi:10.70675/3635da7az5e15z4aaaz890cz02e6ace799ec
PGC-1α régule un programme onco-métabolique capable de réprimer l’agressivité du cancer de la prostate
Kaminski, L. (2018) · theses.fr (ABES) · doi:10.70675/7f6ae88bz4f3cz49d3zafcdz8682254b2be3
Role of VDAC1 hypoxic form, VDAC1-∆C, in the expression of primary cilia and tumor progression
Fabbri, L. (2019) · theses.fr (ABES) · doi:10.70675/7a53239dzc652z4ea4z8b95z4a71961c83b4
Influence fonctionnelle de l’IMC, de la densité mammaire et du statut ménopausique sur le dialogue entre adipocytes et cellules tumorales mammaires
Zaoui, M. (2018) · theses.fr (ABES) · doi:10.70675/7e124db9z9e85z4d81z906fz646d6224b036
Identification de régulateurs clés de la carcinogenèse hépatique humaine : Études clinico-pathologiques, moléculaires et fonctionnelles
Santos, A. D. (2019) · theses.fr (ABES) · doi:10.70675/50131371z9cf2z4925zad84ze1758a9a5831
Étude de nouvelles fonctions moléculaires et cellulaires de l'Hexokinase 2 dans le cancer
Watzky, M. (2023) · theses.fr (ABES) · doi:10.70675/73163a81z2c2bz4e11zaba1z8dc110d9c697
Influence and reliance of Chlamydia trachomatis on host glucose metabolism
N’Gadjaga, M. D. (2021) · doi:10.70675/1cd46d05z4460z406ez8c4bz8deb1fc872a3
EVT-701 : targeting electron transport chain complex I as therapeutic approach in cancer
Yolba, R. L. (2021) · theses.fr (ABES) · doi:10.70675/9cadea77z03ccz4a54zb381zf34a432615a5
Virus de l'hépatite E : Mécanismes d'entrée et modifications du métabolisme cellulaire
Glaziou, Q. (2023) · theses.fr (ABES) · doi:10.70675/7d870e61z864fz4bbdzabe6z09bb1f895b46
Simulations de dynamique moléculaire à haute résolution des isoformes 1 et 2 de la pyruvate kinase musculaire
Delobelle, Q. (2024) · theses.fr (ABES) · doi:10.70675/a7e826aazb648z4cecza50dzbe987acb77e6
Deciphering the metabolic bases of Drosophila intestinal tumors
Delamotte, P. (2024) · theses.fr (ABES) · doi:10.70675/c62595f4zbfe2z4ee5zba1az272c10f57e2a
BACH1 stabilization by antioxidants facilitates hepatocellular carcinoma metastasis
Bu, Q., Wang, Z., (27728), Q. W., Qi, X., Lin, S., Liu, S., & Zhang, Y. (2026) · Cell Death and Disease · doi:10.1038/s41419-026-08865-0
AL109933.1 inhibits hepatocellular carcinoma progression via downregulating the Warburg effect and inactivating the YY1/PKM2/PIK3R1/PI3K/AKT/ mTOR/HIF-1α axis
Li, Y., HOU, Y., Han, Y., Feng, W., Zong, W., Wang, X., Chen, G., Tan, X., Zhang, B., Ju, L., et al. (2026) · Cellular Signalling · doi:10.1016/j.cellsig.2026.112675
Engineering the “pro-healing niche”: Hydrogel-driven immunometabolic reprogramming for diabetic foot ulcers
Xu, Z., Yang, Z., Liu, R., Wang, Y., Li, Y., & Sun, Q. (2026) · Biomaterials Advances · doi:10.1016/j.bioadv.2026.215033
Hypoxia-preconditioned dental pulp stem cells alleviate acetaminophen-induced liver failure via promoting MYC-HIF1A/HIF-1α-BNIP3-mediated mitophagy
Li, J., Yang, Q., Pang, P., Liu, Y., Liu, X., Zhong, W., Zhang, R., Sun, W., He, Y., & Ye, Q. (2026) · Autophagy · doi:10.1080/15548627.2026.2694664
Self-citation
Immunometabolic Stress and Immune Suppression in Clear-Cell Renal Cell Carcinoma: Perspectives in Therapeutic Strategy
Nguyen, T. V., & Hsu, T. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27136021 · Cited by 1
Glucose and Lactate, Starters or Intermediates of Cancer Metabolic Rewiring
Mendes, C. (2026) · Advances in experimental medicine and biology · doi:10.1007/978-3-032-12166-0_2
From Tissue Specificity to Systemic Cues: Shaping MYC-Driven Tumor Metabolism
Alamoudi, A. A., Mao, Y., Zadra, G., & Labbé, D. P. (2026) · Cancer Research · doi:10.1158/0008-5472.can-26-0142
Physapubescin B From Physalis: A Food‐Derived Withanolide for Cancer Chemoprevention and Nutraceutical Development
Koch, W., Stępnik, K., Wawruszak, A., Okoń, E., Jarząb, A., Gaweł‐Bęben, K., Michalak-Tomczyk, M., Jachuła, J., Zdziebło, M., Helon, P., et al. (2026) · eFood · doi:10.1002/efd2.70196
CircRNA circuits orchestrate lactate metabolism in gastrointestinal cancer progression
Chen, Q., Zhou, H., Shen, Z., Zhou, Y., Ding, J., 段昌虎, Cao, X., Liu, Y., Wang, L., & He, W. (2026) · Open Life Sciences · doi:10.1515/biol-2025-1351
Self-citation
Targeting MYC-Driven Cancers: From Oncogenic Addiction to Therapeutic Vulnerability
Sainero‐Alcolado, L., Lama, D., Alzrigat, M., & Arsenian‐Henriksson, M. (2026) · BioDrugs · doi:10.1007/s40259-026-00798-6
Inhibition of Hexokinase 2 Undermines Cartilage Health and Accelerates Osteoarthritis
Xu, H., Zhang, X., Fu, Y., Liu, G., Deng, D., Ren, F., Yuan, S., Lin, Y., Lai, R., Li, K., et al. (2026) · Cartilage · doi:10.1177/19476035261494285
Beyond tumor cell–intrinsic metabolism: Hexokinase 2 as a central regulator of the tumor microenvironment
Wang, X., Pei, H., Yao, F., Zhu, S., & Zheng, S. (2026) · Genes & Diseases · doi:10.1016/j.gendis.2026.102517
Molecular mechanisms and targeted therapeutic strategies of TIGAR in regulating energy metabolism to promote tumor proliferation in breast cancer
Zhai, M., Wang, P., & Ou, Y. (2026) · Breast Cancer · doi:10.1007/s12282-026-01929-1
BindingDB Entry 50044844: Discovery and optimization of 4,5-diarylisoxazoles as potent dual inhibitors of pyruvate dehydrogenase kinase and heat shock protein 90.
BindingDB (2016) · UC San Diego · doi:10.7270/q2p270r1
BindingDB Entry 50047588: Unexpected Discovery of Dichloroacetate Derived Adenosine Triphosphate Competitors Targeting Pyruvate Dehydrogenase Kinase To Inhibit Cancer Proliferation.
BindingDB (2017) · UC San Diego · doi:10.7270/q2p55qfz
BindingDB Entry 50002029: Identification of pyruvate dehydrogenase kinase 1 inhibitors with anti-osteosarcoma activity.
BindingDB (2020) · UC San Diego · doi:10.7270/q23n25zg
Emerging Anti-cancer Targets in Mitochondria
Ježek, P., Smolková, K., Dvořák, A., & Olejár, T. (2014) · Springer eBooks · doi:10.1007/978-94-017-8984-4_10
The Dual Role of HIF Hydroxylase PHD3 in Cancer Cell Survival
Rantanen, K. (2012) · UTUPub (University of Turku)

Authors: Kim, J.-W., Gao, P., Liu, Y.-C., Semenza, G. L., & Dang, C. V.
Affiliations: Division of Hematology, Department of Medicine
Graduate Program of Pathobiology
Johns Hopkins University (US)
Corresponding author: Dang, Chi V.
ORCID: Kim, Jung-whan
Gao, Ping
Semenza, Gregg L.
Dang, Chi V.
Venue: Molecular and Cellular Biology
Publisher: Informa UK Limited
Published: 2007-11-01
Volume: 27
Issue: 21
Pages: 7381-7393
ISSN: 0270-7306 (ISSN-L)
1098-5549
DOI: 10.1128/mcb.00440-07
PMC: PMC2169056
OpenAlex: W2105250121
Cited by: 658
References: 87
Citations by year: 2026: 21 · 2025: 29 · 2024: 28 · 2023: 31 · 2022: 49 · 2021: 60 · 2020: 45 · 2019: 48 · 2018: 38 · 2017: 36 · 2016: 38 · 2015: 28 · 2014: 44 · 2013: 29 · 2012: 35
FWCI: 8.37
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Molecular and Cellular Biology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Johns Hopkins University
National Institutes of Health (n01hv28180-13-0-0, NO1-HV-28180)
National Heart, Lung, and Blood Institute (N01 HV028180, N02-HV-28180)
National Cancer Institute (CA 57341, R01CA057341, CA52497)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Kruppel-like factors research
Keywords: HIF-1, c-Myc, vascular endothelial growth factor, hexokinase 2, pyruvate dehydrogenase kinase 1, Warburg effect, glycolysis, mitochondrial respiration, Burkitt lymphoma, tumor hypoxia, angiogenesis, cancer metabolism
MeSH terms: Pyruvate Dehydrogenase Acetyl-Transferring Kinase, Cell Line, DNA, Enzyme Induction, Glucose, Glycolysis, Hexokinase, Humans, Neoplasms, Protein Binding, Regulatory Sequences, Nucleic Acid, Proto-Oncogene Proteins c-myc, Protein Serine-Threonine Kinases, Vascular Endothelial Growth Factor A, Chromatin Immunoprecipitation, Hypoxia-Inducible Factor 1

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Hypoxia-Inducible Factor 1 and Dysregulated c-Myc Cooperatively Induce Vascular Endothelial Growth Factor and Metabolic Switches Hexokinase 2 and Pyruvate Dehydrogenase Kinase 1

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks