The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
miR-206 and -486 Induce Myoblast Differentiation by Downregulating Pax7
Open accessAbstract
The Pax7 transcription factor is required for muscle satellite cell biogenesis and specification of the myogenic precursor lineage. Pax7 is expressed in proliferating myoblasts but is rapidly downregulated during differentiation. Here we report that miR-206 and -486 are induced during myoblast differentiation and downregulate Pax7 by directly targeting its 3' untranslated region (UTR). Expression of either of these microRNAs in myoblasts accelerates differentiation, whereas inhibition of these microRNAs causes persistence of Pax7 protein and delays differentiation. A microRNA-resistant form of Pax7 is sufficient to inhibit differentiation. Since both these microRNAs are induced by MyoD and since Pax7 promotes the expression of Id2, an inhibitor of MyoD, our results revealed a bistable switch that exists either in a Pax7-driven myoblast state or a MyoD-driven myotube state.
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Cites
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Cited by
Satellite Cells and the Muscle Stem Cell Niche
Yin, H., Price, F., & Rudnicki, M. A. (2013) · Physiological Reviews · doi:10.1152/physrev.00043.2011 · Cited by 2,166
Transcriptional mechanisms regulating skeletal muscle differentiation, growth and homeostasis
Braun, T., & Gautel, M. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3118 · Cited by 713
Satellite Cells and Skeletal Muscle Regeneration
Dumont, N. A., Bentzinger, C. F., Sincennes, M., & Rudnicki, M. A. (2015) · Comprehensive Physiology · doi:10.1002/cphy.c140068 · Cited by 719
Muscle-specific microRNAs in skeletal muscle development
Horak, M., Novak, J., & Bienertova-Vasku, J. (2016) · Developmental Biology · doi:10.1016/j.ydbio.2015.12.013 · Cited by 478
Control of satellite cell function in muscle regeneration and its disruption in ageing
Sousa-Victor, P., García-Prat, L., & Muñoz-Cánoves, P. (2022) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-021-00421-2 · Cited by 476
Metadata
- Authors
- Dey, B. K., Gagan, J., & Dutta, A.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 2011-01-01
- Volume
- 31
- Issue
- 1
- Pages
- 203-214
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W2062427797
- Cited by
- 408
- References
- 50
- FWCI
- 9.57
- Type
- journal article
- Language
- en
- Open access
- green
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- Dey, B. K., Gagan, J., & Dutta, A. (2011). miR-206 and -486 Induce Myoblast Differentiation by Downregulating Pax7. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.01009-10
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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