The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Eukaryotic Wobble Uridine Modifications Promote a Functionally Redundant Decoding System
Open accessAbstract
The translational decoding properties of tRNAs are modulated by naturally occurring modifications of their nucleosides. Uridines located at the wobble position (nucleoside 34 [U(34)]) in eukaryotic cytoplasmic tRNAs often harbor a 5-methoxycarbonylmethyl (mcm(5)) or a 5-carbamoylmethyl (ncm(5)) side chain and sometimes an additional 2-thio (s(2)) or 2'-O-methyl group. Although a variety of models explaining the role of these modifications have been put forth, their in vivo functions have not been defined. In this study, we utilized recently characterized modification-deficient Saccharomyces cerevisiae cells to test the wobble rules in vivo. We show that mcm(5) and ncm(5) side chains promote decoding of G-ending codons and that concurrent mcm(5) and s(2) groups improve reading of both A- and G-ending codons. Moreover, the observation that the mcm(5)U(34)- and some ncm(5)U(34)-containing tRNAs efficiently read G-ending codons challenges the notion that eukaryotes do not use U-G wobbling.
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Cites
Universal rules and idiosyncratic features in tRNA identity
Giege, R., Sissler, M., & Florentz, C. (1998) · Nucleic Acids Research · doi:10.1093/nar/26.22.5017 · Cited by 769
Yokoyama, S., Watanabe, T., Murao, K., Ishikura, H., Yamaizumi, Z., Nishimura, S., & Miyazawa, T. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.15.4905 · Cited by 271
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Metadata
- Authors
- Johansson, M. J. O., Esberg, A., Huang, B., Björk, G. R., & Byström, A. S.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 2008-05-01
- Volume
- 28
- Issue
- 10
- Pages
- 3301-3312
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W2148399893
- Cited by
- 254
- References
- 2
- FWCI
- 4.22
- Type
- journal article
- Language
- en
- Open access
- green
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- Johansson, M. J. O., Esberg, A., Huang, B., Björk, G. R., & Byström, A. S. (2008). Eukaryotic Wobble Uridine Modifications Promote a Functionally Redundant Decoding System. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.01542-07
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