Cited by 73RNA modifications and cancerRNA regulation and diseaseRNA and protein synthesis mechanisms

Role of RNA modifications in brain and behavior

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Jung, Y., Goldman, D.·2018·Genes, Brain and Behavior

Abstract

Much progress in our understanding of RNA metabolism has been made since the first RNA nucleoside modification was identified in 1957. Many of these modifications are found in noncoding RNAs but recent interest has focused on coding RNAs. Here, we summarize current knowledge of cellular consequences of RNA modifications, with a special emphasis on neuropsychiatric disorders. We present evidence for the existence of an “RNA code,” similar to the histone code, that fine‐tunes gene expression in the nervous system by using combinations of different RNA modifications. Unlike the relatively stable genetic code, this combinatorial RNA epigenetic code, or epitranscriptome, may be dynamically reprogrammed as a cause or consequence of psychiatric disorders. We discuss potential mechanisms linking disregulation of the epitranscriptome with brain disorders and identify potential new avenues of research.

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  • m6A accounts for two-thirds of all RNA modifications that can be written, read, and erased via the actions of a complex network of proteins.

    “To date, among all RNA modifications, N6-methyladenosine (m6A) accounts for two-thirds of all RNA modifications that can be “written”, “read”, and “erased” via the actions of a complex network of proteins348,349”

    From Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential (2023) · cites this paper as [348]

    The “Writers, Readers and Erasers” section describes proteins that add, recognize and erase m6A. The “N-6-methyladenosine (m6A)” section gives its frequency as 0.2% of total RNA transcripts, but the paper does not say m6A accounts for two-thirds of all RNA modifications. Page numbers are unavailable in our copy. (LLM, conf=0.88)

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Authors
Jung, Y., & Goldman, D.
Affiliations
National Institutes of Health (US)
Corresponding author
Goldman, D.
Venue
Genes, Brain and Behavior
Publisher
Wiley
Published
2018-03
Volume
17
Issue
3
Pages
e12444-e12444
ISSN
  • 1601-183X (ISSN-L)
  • 1601-1848
OpenAlex
W2774828372
Cited by
66
References
125
Citations by year
2026: 2 · 2025: 9 · 2024: 7 · 2023: 9 · 2022: 8 · 2021: 19 · 2020: 7 · 2019: 4 · 2018: 1
FWCI
0.31
Type
journal article
Language
en
Open access
Locations
  • Genes Brain & Behavior (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Institute on Alcohol Abuse and Alcoholism (Z01AA000280)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA modifications and cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
Keywords
RNA modification, epitranscriptome, epitranscriptomics, neuropsychiatric disorders, gene expression regulation, non-coding RNA, coding RNA, brain disorders
MeSH terms
Brain, Gene Expression Regulation, Humans, RNA, RNA Processing, Post-Transcriptional, RNA, Messenger, Gene Expression, RNA, Untranslated, Epigenesis, Genetic, Epigenomics

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