Role of RNA modifications in brain and behavior
Open accessAbstract
Much progress in our understanding of RNA metabolism has been made since the first RNA nucleoside modification was identified in 1957. Many of these modifications are found in noncoding RNAs but recent interest has focused on coding RNAs. Here, we summarize current knowledge of cellular consequences of RNA modifications, with a special emphasis on neuropsychiatric disorders. We present evidence for the existence of an “RNA code,” similar to the histone code, that fine‐tunes gene expression in the nervous system by using combinations of different RNA modifications. Unlike the relatively stable genetic code, this combinatorial RNA epigenetic code, or epitranscriptome, may be dynamically reprogrammed as a cause or consequence of psychiatric disorders. We discuss potential mechanisms linking disregulation of the epitranscriptome with brain disorders and identify potential new avenues of research.
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m6A accounts for two-thirds of all RNA modifications that can be written, read, and erased via the actions of a complex network of proteins.
“To date, among all RNA modifications, N6-methyladenosine (m6A) accounts for two-thirds of all RNA modifications that can be “written”, “read”, and “erased” via the actions of a complex network of proteins348,349”
From Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential (2023) · cites this paper as [348]
The “Writers, Readers and Erasers” section describes proteins that add, recognize and erase m6A. The “N-6-methyladenosine (m6A)” section gives its frequency as 0.2% of total RNA transcripts, but the paper does not say m6A accounts for two-thirds of all RNA modifications. Page numbers are unavailable in our copy. (LLM, conf=0.88)
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- Authors
- Jung, Y., & Goldman, D.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Goldman, D.
- ORCID
- Venue
- Genes, Brain and Behavior
- Publisher
- Wiley
- Published
- 2018-03
- Volume
- 17
- Issue
- 3
- Pages
- e12444-e12444
- ISSN
- 1601-183X (ISSN-L)
- 1601-1848
- PMC
- PMC6233296
- OpenAlex
- W2774828372
- Cited by
- 66
- References
- 125
- Citations by year
- 2026: 2 · 2025: 9 · 2024: 7 · 2023: 9 · 2022: 8 · 2021: 19 · 2020: 7 · 2019: 4 · 2018: 1
- FWCI
- 0.31
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Genes Brain & Behavior (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute on Alcohol Abuse and Alcoholism (Z01AA000280)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA modifications and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Keywords
- RNA modification, epitranscriptome, epitranscriptomics, neuropsychiatric disorders, gene expression regulation, non-coding RNA, coding RNA, brain disorders
- MeSH terms
- Brain, Gene Expression Regulation, Humans, RNA, RNA Processing, Post-Transcriptional, RNA, Messenger, Gene Expression, RNA, Untranslated, Epigenesis, Genetic, Epigenomics
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