The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.
Di- and Tri- but Not Monomethylation on Histone H3 Lysine 36 Marks Active Transcription of Genes Involved in Flowering Time Regulation and Other Processes in Arabidopsis thaliana
Open accessAbstract
Histone lysines can be mono-, di-, or trimethylated, providing an ample magnitude of epigenetic information for transcription regulation. In fungi, SET2 is the sole methyltransferase responsible for mono-, di-, and trimethylation of H3K36. Here we show that in Arabidopsis thaliana, the degree of H3K36 methylation is regulated by distinct methyltransferases. The SET2 homologs SDG8 and SDG26 each can methylate oligonucleosomes in vitro, and both proteins are localized in the nucleus. While the previously reported loss-of-function sdg8 mutants have an early-flowering phenotype, the loss-of-function sdg26 mutants show a late-flowering phenotype. Consistently, several MADS-box flowering repressors are down-regulated by sdg8 but up-regulated by sdg26. The sdg8 but not the sdg26 mutant plants show a dramatically reduced level of both di- and trimethyl-H3K36 and an increased level of monomethyl-H3K36. SDG8 is thus specifically required for di- and trimethylation of H3K36. Our results further establish that H3K36 di- and tri- but not monomethylation correlates with transcription activation. Finally, we show that SDG8 and VIP4, which encodes a component of the PAF1 complex, act independently and synergistically in transcription regulation. Together our results reveal that the deposition of H3K36 methylation is finely regulated, possibly to cope with the complex regulation of growth and development in higher eukaryotes.
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Cites
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Cited by
Comprehensive Analysis of Silencing Mutants Reveals Complex Regulation of the Arabidopsis Methylome
Stroud, H., Greenberg, M. V. C., Feng, S., Bernatavichute, Y. V., & Jacobsen, S. E. (2013) · Cell · doi:10.1016/j.cell.2012.10.054 · Cited by 873
Histone Methylation in Higher Plants
Liu, C., Lu, F., Cui, X., & Cao, X. (2010) · Annual Review of Plant Biology · doi:10.1146/annurev.arplant.043008.091939 · Cited by 732
Genome-wide analysis of mono-, di- and trimethylation of histone H3 lysine 4 in Arabidopsis thaliana
Zhang, X., Bernatavichute, Y. V., Cokus, S., Pellegrini, M., & Jacobsen, S. E. (2009) · Genome Biology · doi:10.1186/gb-2009-10-6-r62 · Cited by 614
Reversal of Histone Methylation: Biochemical and Molecular Mechanisms of Histone Demethylases
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Jasmonate-mediated wound signalling promotes plant regeneration
Zhang, G., Zhao, F., Chen, L., Pan, Y., Sun, L., Bao, N., Zhang, T., Cui, C.-X., Qiu, Z., Zhang, Y., et al. (2019) · Nature Plants · doi:10.1038/s41477-019-0408-x · Cited by 308
Self-citation
Metadata
- Authors
- Xu, L., Zhao, Z., Dong, A., Soubigou-Taconnat, L., Renou, J.-P., Steinmetz, A., & Shen, W.-H.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 2008-02-01
- Volume
- 28
- Issue
- 4
- Pages
- 1348-1360
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W2163813691
- Cited by
- 329
- References
- 63
- FWCI
- 23.10
- Type
- journal article
- Language
- en
- Open access
- green
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- Xu, L., Zhao, Z., Dong, A., Soubigou-Taconnat, L., Renou, J.-P., Steinmetz, A., & Shen, W.-H. (2008). Di- and Tri- but Not Monomethylation on Histone H3 Lysine 36 Marks Active Transcription of Genes Involved in Flowering Time Regulation and Other Processes in Arabidopsis thaliana. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.01607-07
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