The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Inhibiting the Mitochondrial Fission Machinery Does Not Prevent Bax/Bak-Dependent Apoptosis
Open accessAbstract
Apoptosis, induced by a number of death stimuli, is associated with a fragmentation of the mitochondrial network. These morphological changes in mitochondria have been shown to require proteins, such as Drp1 or hFis1, which are involved in regulating the fission of mitochondria. However, the precise role of mitochondrial fission during apoptosis remains elusive. Here we report that inhibiting the fission machinery in Bax/Bak-mediated apoptosis, by down-regulating of Drp1 or hFis1, prevents the fragmentation of the mitochondrial network and partially inhibits the release of cytochrome c from the mitochondria but fails to block the efflux of Smac/DIABLO. In addition, preventing mitochondrial fragmentation does not inhibit cell death induced by Bax/Bak-dependent death stimuli, in contrast to the effects of Bcl-xL or caspase inhibition. Therefore, the fission of mitochondria is a dispensable event in Bax/Bak-dependent apoptosis.
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The Role of Dynamin-Related Protein 1, a Mediator of Mitochondrial Fission, in Apoptosis
Frank, S., Gaume, B., Bergmann-Leitner, E. S., Leitner, W. W., Robert, E. G., Catez, F., Smith, C. L., & Youle, R. J. (2001) · Developmental Cell · doi:10.1016/s1534-5807(01)00055-7 · Cited by 1,755
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Roles of the mammalian mitochondrial fission and fusion mediators Fis1, Drp1, and Opa1 in apoptosis
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Mitofusin 1 and 2 play distinct roles in mitochondrial fusion reactions via GTPase activity
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“Mitochondrial fusion in mammalian cells utilizes a different set of proteins: the large transmembrane GTPase mitofusins (Mfn1, Mfn2) anchored on the MOM and dynamin-like GTPase OPA1 (Optic Atrophy 1) located in the mitochondrial intermembrane space (10, 30, 34, 35, 54, 60).”
BackgroundA role for Fis1 in both mitochondrial and peroxisomal fission in mammalian cells
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Cited by
The BCL-2 protein family: opposing activities that mediate cell death
Youle, R. J., & Strasser, A. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2308 · Cited by 4,679
Mitochondria and cell death: outer membrane permeabilization and beyond
Tait, S. W. G., & Green, D. R. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2952 · Cited by 2,593
The Role of Mitochondria in Apoptosis
Wang, C., & Youle, R. J. (2009) · Annual Review of Genetics · doi:10.1146/annurev-genet-102108-134850 · Cited by 1,987
Functions and dysfunctions of mitochondrial dynamics
Detmer, S. A., & Chan, D. C. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2275 · Cited by 1,369
Mitochondria in Apoptosis: Bcl-2 Family Members and Mitochondrial Dynamics
Martinou, J.-C., & Youle, R. J. (2011) · Developmental Cell · doi:10.1016/j.devcel.2011.06.017 · Cited by 1,368
Self-citation
Metadata
- Authors
- Parone, P. A., James, D. I., Da Cruz, S., Mattenberger, Y., Donzé, O., Barja, F., & Martinou, J.-C.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 2006-10-01
- Volume
- 26
- Issue
- 20
- Pages
- 7397-7408
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W2169537129
- Cited by
- 231
- References
- 10
- FWCI
- 8.84
- Type
- journal article
- Language
- en
- Open access
- green
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- Parone, P. A., James, D. I., Da Cruz, S., Mattenberger, Y., Donzé, O., Barja, F., & Martinou, J.-C. (2006). Inhibiting the Mitochondrial Fission Machinery Does Not Prevent Bax/Bak-Dependent Apoptosis. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.02282-05
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