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The glucocorticoid receptor binds to a sequence overlapping the TATA box of the human osteocalcin promoter: a potential mechanism for negative regulation.
Open accessAbstract
Expression of the human osteocalcin promoter is negatively regulated by glucocorticoids in vivo. In vitro DNase I and exonuclease III footprinting analysis showed binding of purified glucocorticoid receptor in close proximity to and overlapping with the TATA box of the osteocalcin gene. These results imply competition or interference with binding of the TATA box-binding transcription factor IID as a mechanism of repression of this gene by glucocorticoids. In support of this notion, point mutation analysis of the receptor binding site indicated that flanking nucleotides and not the TATA box motif per se were important for receptor interaction. Moreover, DNA binding competition assays showed specific binding of the receptor only to the TATA box region of the osteocalcin gene and not to the corresponding region of an immunoglobulin heavy-chain promoter.
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Cites
Gene regulation by steroid hormones
Beato, M. (1989) · Cell · doi:10.1016/0092-8674(89)90237-7 · Cited by 3,383
Drouin, J., Trifiro, M. A., Plante, R. K., Nemer, M., Eriksson, P., & Wrange, Ö. (1989) · Molecular and Cellular Biology · doi:10.1128/mcb.9.12.5305-5314.1989 · Cited by 283
Cited by
Mechanisms involved in the side effects of glucocorticoids
SCHACKE, H. (2002) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(02)00297-8 · Cited by 1,847
STEIN, G. S., & LIAN, J. B. (1993) · Endocrine Reviews · doi:10.1210/edrv-14-4-424 · Cited by 1,078
McKay, L. I., & Cidlowski, J. A. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.4.0375 · Cited by 805
Ratman, D., Vanden Berghe, W., Dejager, L., Libert, C., Tavernier, J., Beck, I. M., & De Bosscher, K. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2012.12.014 · Cited by 411
The human glucocorticoid receptor: One gene, multiple proteins and diverse responses
ZHOU, J., & CIDLOWSKI, J. (2005) · Steroids · doi:10.1016/j.steroids.2005.02.006 · Cited by 372
Metadata
- Authors
- Strömstedt, P. E., Poellinger, L., Gustafsson, J. A., & Carlstedt-Duke, J.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 1991-06
- Volume
- 11
- Issue
- 6
- Pages
- 3379-3383
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W2118168806
- Cited by
- 164
- References
- 2
- FWCI
- 7.44
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: The glucocorticoid receptor binds to a sequence overlapping the TATA box of the human osteocalcin promoter: a potential mechanism for negative regulation. https://app.cochat.ai/papers/10.1128/mcb.11.6.3379
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- Strömstedt, P. E., Poellinger, L., Gustafsson, J. A., & Carlstedt-Duke, J. (1991). The glucocorticoid receptor binds to a sequence overlapping the TATA box of the human osteocalcin promoter: a potential mechanism for negative regulation. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.11.6.3379
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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