How glucocorticoid receptors modulate the activity of other transcription factors: A scope beyond tethering
Abstract
The activity of the glucocorticoid receptor (GR), a nuclear receptor transcription factor belonging to subclass 3C of the steroid/thyroid hormone receptor superfamily, is typically triggered by glucocorticoid hormones. Apart from driving gene transcription via binding onto glucocorticoid response elements in regulatory regions of particular target genes, GR can also inhibit gene expression via transrepression, a mechanism largely based on protein:protein interactions. Hereby GR can influence the activity of other transcription factors, without contacting DNA itself. GR is known to inhibit the activity of a growing list of immune-regulating transcription factors. Hence, GCs still rule the clinic for treatments of inflammatory disorders, notwithstanding concomitant deleterious side effects. Although patience is a virtue when it comes to deciphering the many mechanisms GR uses to influence various signaling pathways, the current review is testimony of the fact that groundbreaking mechanistic work has been accumulating over the past years and steadily continues to grow.
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Nuclear receptors act by forming homodimers or heterodimers.
“Nuclear receptors act by forming homodimers or heterodimers. For example, the glucocorticoid receptor [1] and estrogen receptor [2] form a homodimer, and insect ecdysone receptor (EcR) forms a heterodimer with an ultraspiracle protein (USP), the ortholog of retinoid X receptor in vertebrates [3].”
From G-protein-coupled receptor participates in 20-hydroxyecdysone signaling on the plasma membrane (2014) · cites this paper as [1]
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1 retracted
RETRACTED: Maturation of MicroRNA Is Hormonally Regulated by a Nuclear Receptor
Yamagata, K., Fujiyama, S., Ito, S., Ueda, T., Murata, T., Naitou, M., Takeyama, K., Minami, Y., O’Malley, B. W., & Kato, S. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.08.017 · Cited by 197 · see citing works
RetractedComprehensive Mapping of Long-Range Interactions Reveals Folding Principles of the Human Genome
Lieberman-Aiden, E., van Berkum, N. L., Williams, L., Imakaev, M., Ragoczy, T., Telling, A., Amit, I., Lajoie, B. R., Sabo, P. J., Dorschner, M. O., et al. (2009) · Science · doi:10.1126/science.1181369 · Cited by 8,898 · see citing works
The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation
Ricote, M., Li, A. C., Willson, T. M., Kelly, C. J., & Glass, C. K. (1998) · Nature · doi:10.1038/34178 · Cited by 3,525 · see citing works
Mechanisms involved in the side effects of glucocorticoids
SCHACKE, H. (2002) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(02)00297-8 · Cited by 1,847 · see citing works
Molecular and Cellular Endocrinology
Rainey, W. E., & Rodgers, R. J. (2004) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2004.10.007 · Cited by 1,309 · see citing works
Diamond, M. I., Miner, J. N., Yoshinaga, S. K., & Yamamoto, K. R. (1990) · Science · doi:10.1126/science.2119054 · Cited by 1,274 · see citing works
HDAC6 Regulates Hsp90 Acetylation and Chaperone-Dependent Activation of Glucocorticoid Receptor
Kovacs, J. J., Murphy, P. J. M., Gaillard, S., Zhao, X., Wu, J.-T., Nicchitta, C. V., Yoshida, M., Toft, D. O., Pratt, W. B., & Yao, T.-P. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.04.021 · Cited by 1,153 · see citing works
Activation of human aortic smooth-muscle cells is inhibited by PPARα but not by PPARγ activators
Staels, B., Köenig, W., Habib, A., Merval, R., Lebret, M., Pineda‐Torra, I., Delerive, P., Fadel, A., Chinetti, G., Fruchart, J., et al. (1998) · Nature · doi:10.1038/31701 · Cited by 1,134 · see citing works
Delerive, P., De Bosscher, K., Besnard, S., Vanden Berghe, W., Peters, J. M., Gonzalez, F. J., Fruchart, J.-C., Tedgui, A., Haegeman, G., & Staels, B. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.45.32048 · Cited by 1,089 · see citing works
DNA binding of the glucocorticoid receptor is not essential for survival
Reichardt, H. M., Kaestner, K. H., Tuckermann, J., Kretz, O., Wessely, O., Bock, R., Gass, P., Schmid, W., Herrlich, P., Angel, P., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)81183-6 · Cited by 1,068 · see citing works
Glucocorticoid resistance in inflammatory diseases
Barnes, P. J., & Adcock, I. M. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60326-3 · Cited by 983 · see citing works
Chromatin accessibility pre-determines glucocorticoid receptor binding patterns
John, S., Sabo, P. J., Thurman, R. E., Sung, M.-H., Biddie, S. C., Johnson, T. A., Hager, G. L., & Stamatoyannopoulos, J. A. (2011) · Nature Genetics · doi:10.1038/ng.759 · Cited by 954 · see citing works
De Bosscher, K., Vanden Berghe, W., & Haegeman, G. (2003) · Endocrine Reviews · doi:10.1210/er.2002-0006 · Cited by 898 · see citing works
Bledsoe, R. K., Montana, V. G., Stanley, T. B., Delves, C. J., Apolito, C. J., McKee, D. D., Consler, T. G., Parks, D. J., Stewart, E. L., Willson, T. M., et al. (2002) · Cell · doi:10.1016/s0092-8674(02)00817-6 · Cited by 818 · see citing works
Silverman, M. N., & Sternberg, E. M. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06633.x · Cited by 740 · see citing works
Ito, K., Barnes, P. J., & Adcock, I. M. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.18.6891-6903.2000 · Cited by 723 · see citing works
Multiple and cooperative trans-activation domains of the human glucocorticoid receptor
Hollenberg, S. M., & Evans, R. M. (1988) · Cell · doi:10.1016/0092-8674(88)90145-6 · Cited by 685 · see citing works
P-TEFb, a Cyclin-Dependent Kinase Controlling Elongation by RNA Polymerase II
Price, D. H. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.8.2629-2634.2000 · Cited by 678 · see citing works
Functional interactions between Stat5 and the glucocorticoid receptor
Stöcklin, E., Wissler, M., Gouilleux, F., & Groner, B. (1996) · Nature · doi:10.1038/383726a0 · Cited by 675 · see citing works
DNA binding site sequence directs glucocorticoid receptor structure and activity
Meijsing, S. H., Pufall, M. A., So, A. Y., Bates, D. L., Chen, L., & Yamamoto, K. R. (2009) · Science · doi:10.1126/science.1164265 · Cited by 673 · see citing works
Molecular determinants of crosstalk between nuclear receptors and toll-like receptors
Ogawa, S., Lozach, J., Benner, C., Pascual, G., Tangirala, R. K., Westin, S., Hoffmann, A., Subramaniam, S., David, M., Rosenfeld, M. G., et al. (2005) · Cell · doi:10.1016/j.cell.2005.06.029 · Cited by 647 · see citing works
Ito, K., Yamamura, S., Essilfie-Quaye, S., Cosio, B., Ito, M., Barnes, P. J., & Adcock, I. M. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20050466 · Cited by 638 · see citing works
The Human Glucocorticoid Receptor β Isoform
Oakley, R. H., Sar, M., & Cidlowski, J. A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.16.9550 · Cited by 562 · see citing works
Nissen, R. M., & Yamamoto, K. R. (2000) · Genes & Development · doi:10.1101/gad.827900 · Cited by 559 · see citing works
Surjit, M., Ganti, K. P., Mukherji, A., Ye, T., Hua, G., Metzger, D., Li, M., & Chambon, P. (2011) · Cell · doi:10.1016/j.cell.2011.03.027 · Cited by 551 · cited 1× · see citing works
“(Surjit et al., 2011).”
Reddy, T. E., Pauli, F., Sprouse, R. O., Neff, N. F., Newberry, K. M., Garabedian, M. J., & Myers, R. M. (2009) · Genome Research · doi:10.1101/gr.097022.109 · Cited by 543 · see citing works
Nielsen, R., Pedersen, T. Å., Hagenbeek, D., Moulos, P., Siersbæk, R., Megens, E., Denissov, S., Børgesen, M., Françoijs, K., Mandrup, S., et al. (2008) · Genes & Development · doi:10.1101/gad.501108 · Cited by 520 · see citing works
Ito, K., Lim, S., Caramori, G., Cosío, B. G., Chung, K. F., Adcock, I. M., & Barnes, P. J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.132556899 · Cited by 512 · see citing works
Transcription Factor AP1 Potentiates Chromatin Accessibility and Glucocorticoid Receptor Binding
Biddie, S. C., John, S., Sabo, P. J., Thurman, R. E., Johnson, T. A., Schiltz, R. L., Miranda, T. B., Sung, M.-H., Trump, S., Lightman, S. L., et al. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.06.016 · Cited by 503 · see citing works
Crosstalk between Glucocorticoid Receptor and Nutritional Sensor mTOR in Skeletal Muscle
Shimizu, N., Yoshikawa, N., Ito, N., Maruyama, T., Suzuki, Y., Takeda, S.-I., Nakae, J., Tagata, Y., Nishitani, S., Takehana, K., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.01.001 · Cited by 498 · see citing works
Hollenberg, S. M., Giguère, V., Segui, P., & Evans, R. M. (1987) · Cell · doi:10.1016/0092-8674(87)90753-7 · Cited by 497 · see citing works
Allosteric effects of DNA on transcriptional regulators
Lefstin, J. A., & Yamamoto, K. R. (1998) · Nature · doi:10.1038/31860 · Cited by 488 · see citing works
Sakai, D. D., Helms, S. R., Carlstedt‐Duke, J., Gustafsson, J.-Α., ROTTMAN, F. M., & Yamamoto, K. R. (1988) · Genes & Development · doi:10.1101/gad.2.9.1144 · Cited by 448 · see citing works
Bhatt, D. M., Pandya‐Jones, A., Tong, A.-J., Barozzi, I., Lissner, M. M., Natoli, G., Black, D. L., & Smale, S. T. (2012) · Cell · doi:10.1016/j.cell.2012.05.043 · Cited by 442 · see citing works
Van Raalte, D. H., Ouwens, D. M., & Diamant, M. (2009) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2008.02067.x · Cited by 439 · see citing works
NF-κB Binds P-TEFb to Stimulate Transcriptional Elongation by RNA Polymerase II
Barborič, M., Nissen, R. M., Kanazawa, S., Jabrane‐Ferrat, N., & Peterlin, B. M. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00314-8 · Cited by 434 · see citing works
Rauch, A., Seitz, S., Baschant, U., Schilling, A., Illing, A., Stride, B. D., Kirilov, M., Mandic, V., Takacz, A., Schmidt-Ullrich, R., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.05.005 · Cited by 423 · see citing works
The glucocorticoid responses are shaped by molecular chaperones
Grad, I., & Picard, D. (2007) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2007.05.018 · Cited by 423 · see citing works
Molecular mechanisms of glucocorticoid action and resistance
Schaaf, M. J. M., & Cidlowski, J. A. (2002) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(02)00263-7 · Cited by 417 · see citing works
Disassembly of Transcriptional Regulatory Complexes by Molecular Chaperones
Freeman, B. C., & Yamamoto, K. R. (2002) · Science · doi:10.1126/science.1073051 · Cited by 400 · see citing works
ChIP‐Seq of ERα and RNA polymerase II defines genes differentially responding to ligands
Welboren, W.-J., van Driel, M. A., Janssen‐Megens, E. M., van Heeringen, S. J., Sweep, F. C. G. J., Span, P. N., & Stunnenberg, H. G. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.88 · Cited by 395 · see citing works
TLR recognition of self nucleic acids hampers glucocorticoid activity in lupus
Guiducci, C., Gong, M., Xu, Z., Gill, M. A., Chaussabel, D., Meeker, T., Chan, J. H., Wright, T. B., Punaro, M., Bolland, S. M., et al. (2010) · Nature · doi:10.1038/nature09102 · Cited by 380 · see citing works
Oakley, R. H., & Cidlowski, J. A. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.r110.179325 · Cited by 373 · see citing works
Newton, R. C., & Holden, N. S. (2007) · Molecular Pharmacology · doi:10.1124/mol.107.038794 · Cited by 325 · see citing works
Determinants of Cell- and Gene-Specific Transcriptional Regulation by the Glucocorticoid Receptor
So, A. Y., Chaivorapol, C., Bolton, E. C., Li, H., & Yamamoto, K. R. (2007) · PLoS Genetics · doi:10.1371/journal.pgen.0030094 · Cited by 304 · see citing works
Beck, I. M. E., Vanden Berghe, W., Vermeulen, L., Yamamoto, K. R., Haegeman, G., & De Bosscher, K. (2009) · Endocrine Reviews · doi:10.1210/er.2009-0013 · Cited by 298 · see citing works
Self-citationPan, D., Kocherginsky, M., & Conzen, S. D. (2011) · Cancer Research · doi:10.1158/0008-5472.can-11-0362 · Cited by 298 · see citing works
Groeneweg, F. L., Karst, H., de Kloet, E. R., & Joëls, M. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.06.020 · Cited by 289 · see citing works
Estrogen Receptor Target Gene: An Evolving Concept
Carroll, J. S., & Brown, M. A. (2006) · Molecular Endocrinology · doi:10.1210/me.2005-0334 · Cited by 284 · see citing works
Crosstalk between the glucocorticoid receptor and other transcription factors: Molecular aspects
Kassel, O., & Herrlich, P. (2007) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2007.07.003 · Cited by 277 · see citing works
Anti-inflammatory functions of glucocorticoid-induced genes
Clark, A. R. (2007) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2007.04.013 · Cited by 272 · see citing works
Glucocorticoids sensitize the innate immune system through regulation of the NLRP3 inflammasome
Busillo, J. M., Azzam, K. M., & Cidlowski, J. A. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.275370 · Cited by 264 · see citing works
Gene regulation by the glucocorticoid receptor: structure:function relationship
Kumar, R., & Thompson, E. B. (2005) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2004.12.046 · Cited by 261 · see citing works
Vreugdenhil, E., Veríssimo, C. S., Mariman, R., Kamphorst, J. T., Barbosa, J. S., Zweers, T. J., Champagne, D. L., Schouten, T. G., Meijer, O. C., de Kloet, E. R., et al. (2009) · Endocrinology · doi:10.1210/en.2008-1335 · Cited by 260 · see citing works
Tuckermann, J. P., Kleiman, A., Moriggl, R., Spanbroek, R., Neumann, A., Illing, A., Clausen, B. E., Stride, B., Förster, I., Habenicht, A. J. R., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci28034 · Cited by 252 · see citing works
Glucocorticoid receptor isoforms generate transcription specificity
Lu, N. Z., & Cidlowski, J. A. (2006) · Trends in Cell Biology · doi:10.1016/j.tcb.2006.04.005 · Cited by 247 · see citing works
DNA methylation status predicts cell type‐specific enhancer activity
Wiench, M., John, S., Baek, S., Johnson, T. A., Sung, M., Escobar, T., Simmons, C. A., Pearce, K. H., Biddie, S. C., Sabo, P. J., et al. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.210 · Cited by 245 · see citing works
Bilodeau, S., Vallette-Kasic, S., Gauthier, Y., Figarella-Branger, D. F., Brue, T. C., Berthelet, F., Lacroix, A., Batista, D. L., Stratakis, C. A., Hanson, J., et al. (2006) · Genes & Development · doi:10.1101/gad.1444606 · Cited by 243 · see citing works
Coding exons function as tissue-specific enhancers of nearby genesPreprint
Birnbaum, R. Y., Clowney, E. J., Agamy, O., Kim, M. J., Zhao, J., Yamanaka, T., Pappalardo, Z., Clarke, S. L., Wenger, A. M., Nguyen, L., et al. (2012) · Genome Research · doi:10.1101/gr.133546.111 · Cited by 242 · see citing works
New targets for drug development in asthma
Adcock, I. M., Caramori, G., & Chung, K. F. (2008) · The Lancet · doi:10.1016/s0140-6736(08)61449-x · Cited by 238 · see citing works
Rogatsky, I., Luecke, H. F., Leitman, D. C., & Yamamoto, K. R. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.262671599 · Cited by 226 · see citing works
Collison, A., Mattes, J. E., Plank, M. W., & Foster, P. S. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.04.005 · Cited by 225 · see citing works
A Novel Antiinflammatory Maintains Glucocorticoid Efficacy with Reduced Side Effects
Coghlan, M. J., Jacobson, P. B., Lane, B. C., Nakane, M., Lin, C. W., Elmore, S. W., Kym, P. R., Luly, J. R., Carter, G. W., Turner, R. T., et al. (2003) · Molecular Endocrinology · doi:10.1210/me.2002-0355 · Cited by 224 · see citing works
Tuckermann, J. P., Kleiman, A., Moriggl, R., Spanbroek, R., Neumann, A., Illing, A., Clausen, B. E., Stride, B. D., Förster, I., Habenicht, A. J. R., et al. (2007) · HAL · Cited by 224 · see citing works
Malkoski, S. P., & Dorin, R. I. (1999) · Molecular Endocrinology · doi:10.1210/mend.13.10.0351 · Cited by 223 · see citing works
On the Trail of the Glucocorticoid Receptor: Into the Nucleus and Back
Vandevyver, S., Dejager, L., & Libert, C. (2011) · Traffic · doi:10.1111/j.1600-0854.2011.01288.x · Cited by 222 · see citing works
Self-citationCoactivation of GR and NFKB alters the repertoire of their binding sites and target genesPreprint
Rao, N., McCalman, M. T., Moulos, P., Françoijs, K., Chatziioannou, A. A., Kolisis, F. N., Alexis, Μ. N., Mitsiou, D. J., & Stunnenberg, H. G. (2011) · Genome Research · doi:10.1101/gr.118042.110 · Cited by 218 · see citing works
Luecke, H. F., & Yamamoto, K. R. (2005) · Genes & Development · doi:10.1101/gad.1297105 · Cited by 217 · see citing works
MicroRNAs, new effectors and regulators of NF‐κB
Boldin, M., & Baltimore, D. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01089.x · Cited by 216 · see citing works
Non-genomic glucocorticoid effects to provide the basis for new drug developments
Song, I., & Buttgereit, F. (2006) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2005.11.012 · Cited by 208 · see citing works
The structural basis of direct glucocorticoid- mediated transrepression
Hudson, W. H., Youn, C., & Ortlund, E. A. (2013) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2456 · Cited by 200 · see citing works
Belvisi, M. G., Wicks, S., Battram, C. H., Bottoms, S. E., Redford, J., Woodman, P., Brown, T. J., Webber, S. E., & Foster, M. L. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.3.1975 · Cited by 186 · see citing works
Gehani, S. S., Singh, S. A., Dietrich, N., Christophersen, N. S., Helin, K., & Hansen, K. H. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.08.020 · Cited by 186 · see citing works
Langlais, D., Couture, C., Balsalobre, A., & Drouin, J. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.04.021 · Cited by 185 · see citing works
Ogawa, S., Lozach, J., Jepsen, K., Sawka‐Verhelle, D., Perissi, V., Šášik, R., Rose, D. W., Johnson, R. S., Rosenfeld, M. G., & Glass, C. K. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405786101 · Cited by 185 · see citing works
IκB Kinase α-Mediated Derepression of SMRT Potentiates Acetylation of RelA/p65 by p300
Hoberg, J. E., Popko, A. E., Ramsey, C. S., & Mayo, M. W. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.26.2.457-471.2006 · Cited by 181 · see citing works
Yu, C.-Y., Mayba, O., Lee, J. V., Tran, J., Harris, C. L., Speed, T. P., & Wang, J.-C. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015188 · Cited by 179 · see citing works
MicroRNA Expression Profiling in Mild Asthmatic Human Airways and Effect of Corticosteroid Therapy
Williams, A. E., Larner-Svensson, H., Perry, M. M., Campbell, G. A., Herrick, S. E., Adcock, I. M., Erjefalt, J. S., Chung, K. F., & Lindsay, M. A. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005889 · Cited by 178 · see citing works
Duma, D., Collins, J. B., Chou, J. W., & Cidlowski, J. A. (2010) · Science Signaling · doi:10.1126/scisignal.2001077 · Cited by 178 · see citing works
Stoecklin, E., Wissler, M., Moriggl, R., & Groner, B. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.11.6708 · Cited by 173 · see citing works
Kleiman, A., & Tuckermann, J. P. (2007) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2007.05.009 · Cited by 165 · see citing works
Galliher-Beckley, A. J., Williams, J. G., & Cidlowski, J. A. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.05866-11 · Cited by 164 · see citing works
Strömstedt, P. E., Poellinger, L., Gustafsson, J.-Α., & Carlstedt‐Duke, J. (1991) · Molecular and Cellular Biology · doi:10.1128/mcb.11.6.3379 · Cited by 162 · see citing works
Selective regulation of bone cell apoptosis by translational isoforms of the glucocorticoid receptor
Lu, N. Z., Collins, J. B., Grissom, S. F., & Cidlowski, J. A. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00253-07 · Cited by 160 · see citing works
A New Function for the C-terminal Zinc Finger of the Glucocorticoid Receptor
Lidén, J., Delaunay, F., Rafter, I., Gustafsson, J.-Å., & Okret, S. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.34.21467 · Cited by 155 · see citing works
Glucocorticoid signaling: a nongenomic mechanism for T-cell immunosuppression
Löwenberg, M., Verhaar, A. P., BRINK, G. R. V. D., & Hommes, D. W. (2007) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2007.02.001 · Cited by 154 · see citing works
Kleiman, A., Hübner, S., Parkitna, J. M. R., Neumann, A., Hofer, S., Weigand, M. A., Bauer, M., Schmid, W., Schütz, G., Libert, C., et al. (2012) · The FASEB Journal · doi:10.1096/fj.11-192112 · Cited by 152 · see citing works
Self-citationRegulation of Lipogenesis by Glucocorticoids and Insulin in Human Adipose Tissue
Gathercole, L. L., Morgan, S. A., Bujalska, I. J., Hauton, D., Stewart, P. M., & Tomlinson, J. W. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026223 · Cited by 150 · see citing works
JNK phosphorylation relieves HDAC3‐dependent suppression of the transcriptional activity of c‐Jun
Weiss, C., Schneider, S., Wagner, E. F., Zhang, X. M., Seto, E., & Bohmann, D. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg364 · Cited by 150 · see citing works
The GRIP1:IRF3 interaction as a target for glucocorticoid receptor-mediated immunosuppression
Reily, M. M., Pantoja, C., Hu, X., Chinenov, Y., & Rogatsky, I. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7600919 · Cited by 149 · see citing works
Ki, S. H., Cho, I. J., Choi, D. W., & Kim, S. G. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.10.4150-4165.2005 · Cited by 145 · see citing works
Rivers, C., Levy, A., Hancock, J., Lightman, S., & Norman, M. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.11.6235 · Cited by 141 · see citing works
The Type I Interferon Signaling Pathway Is a Target for Glucocorticoid Inhibition
Flammer, J. R., Dobrovolná, J., Kennedy, M. A., Chinenov, Y. V., Glass, C. K., Ivashkiv, L. B., & Rogatsky, I. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.00146-10 · Cited by 137 · see citing works
A chromatin-modifying function of JNK during stem cell differentiation
Tiwari, V. K., Stadler, M. B., Wirbelauer, C., Paro, R., Schübeler, D., & Beisel, C. (2011) · Nature Genetics · doi:10.1038/ng.1036 · Cited by 133 · see citing works
Glucocorticoid receptor dimerization induces MKP1 to protect against TNF-induced inflammation
Vandevyver, S., Dejager, L., Bogaert, T. V., Kleyman, A., Liu, Y., Tuckermann, J. P., & Libert, C. (2012) · Journal of Clinical Investigation · doi:10.1172/jci60006 · Cited by 133 · see citing works
Self-citationTargeting inflammation using selective glucocorticoid receptor modulators
Bosscher, K. D., Haegeman, G., & Elewaut, D. S. (2010) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2010.04.007 · Cited by 132 · see citing works
Ledderose, C., Möhnle, P., Limbeck, E., Schütz, S., Weis, F., Rink, J., Briegel, J., & Kreth, S. (2012) · Critical Care Medicine · doi:10.1097/ccm.0b013e31825b8ebc · Cited by 130 · see citing works
Selective Glucocorticoid Receptor modulators
Bosscher, K. D. (2010) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2010.02.027 · Cited by 129 · see citing works
Liberman, A. C., Refojo, D., Druker, J., Toscano, M. A., Rein, T., Holsboer, F., & ARZT, E. S. (2007) · The FASEB Journal · doi:10.1096/fj.06-7452com · Cited by 125 · see citing works
Schäcke, H., Zollner, T., Döcke, W., Rehwinkel, H., Jaroch, S., Skuballa, W., Neuhaus, R., May, E., Zügel, U., & Asadullah, K. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00238.x · Cited by 121 · see citing works
Ronacher, K., Hadley, K., Avenant, C., Stubsrud, E., Simons, S. S., Louw, A., & Hapgood, J. P. (2009) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2008.10.008 · Cited by 121 · see citing works
de Lange, P., Segeren, C. M., Koper, J. W., Wiemer, E., Sonneveld, P., Brinkmann, A. O., White, A., Brogan, I. J., de Jong, F. H., & Lamberts, S. W. J. (2010) · Cancer Research · doi:10.1158/0008-5472.3937.61.10 · Cited by 121 · see citing works
Influence of a steroid receptor DNA-binding domain on transcriptional regulatory functions.Preprint
Lefstin, J. A., Thomas, J., & Yamamoto, K. R. (1994) · Genes & Development · doi:10.1101/gad.8.23.2842 · Cited by 120 · see citing works
Lechner, J., Welte, T., Tomasi, J. K., Bruno, P., Cairns, C. A., Gustafsson, J.-Α., & Doppler, W. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.33.20954 · Cited by 118 · see citing works
Guo, L., Lichten, L. A., Ryu, M., Liuzzi, J. P., Wang, F., & Cousins, R. J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914941107 · Cited by 117 · see citing works
Engblom, D., Kornfeld, J., Schwake, L., Tronche, F., Reimann, A., Beug, H., Hennighausen, L. G., Moriggl, R., & Schütz, G. (2007) · Genes & Development · doi:10.1101/gad.426007 · Cited by 117 · see citing works
Stoecklin, E., Wissler, M., Schaetzle, D., Pfitzner, E., & Groner, B. (1999) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(99)00052-7 · Cited by 115 · see citing works
Genome-wide conserved consensus transcription factor binding motifs are hyper-methylated
Choy, M., Movassagh, M., Goh, H. G., Bennett, M. R., Down, T. A., & Foo, R. (2010) · BMC Genomics · doi:10.1186/1471-2164-11-519 · Cited by 115 · see citing works
Lerner, L. R., Henriksen, M. A., Zhang, X., & Darnell, J. E., Jr. (2003) · Genes & Development · doi:10.1101/gad.1135003 · Cited by 115 · see citing works
Adams, M., Meijer, O. C., Wang, J., Bhargava, A., & Pearce, D. (2003) · Molecular Endocrinology · doi:10.1210/me.2002-0305 · Cited by 113 · see citing works
Kassel, O., Schneider, S., Heilbock, C., Litfin, M., Göttlicher, M., & Herrlich, P. A. (2004) · Genes & Development · doi:10.1101/gad.322404 · Cited by 112 · see citing works
Wissink, S., van Heerde, E. C., Schmitz, M. L., Kalkhoven, E., van der Burg, B., Baeuerle, P. A., & van der Saag, P. T. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.35.22278 · Cited by 111 · see citing works
Bougarne, N., Paumelle, R., Caron, S., Hennuyer, N., Mansouri, R. M., Gervois, P. P., Staels, B., Haegeman, G., & Bosscher, K. D. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806742106 · Cited by 110 · see citing works
Baschant, U., Frappart, L., Rauchhaus, U., Bruns, L., Reichardt, H. M., Kamradt, T., Bräuer, R., & Tuckermann, J. P. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1105857108 · Cited by 106 · see citing works
Structure and function of the glucocorticoid receptor
Wright, A. P. H., Zilliacus, J., McEwan, I. J., Dahlman, K., Almlöf, T., Carlstedt‐Duke, J., & Gustafsson, J. (1993) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(93)90052-x · Cited by 103 · see citing works
The role of DNA response elements as allosteric modulators of steroid receptor function
Geserick, C., Meyer, H., & Haendler, B. (2005) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2005.03.007 · Cited by 102 · see citing works
Tao, Y., Williams-Skipp, C., & Scheinman, R. I. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c000526200 · Cited by 96 · see citing works
The Sin3a repressor complex is a master regulator of STAT transcriptional activity
Icardi, L., Mori, R., Gesellchen, V., Eyckerman, S., Cauwer, L. D., Verhelst, J., Vercauteren, K., Saelens, X., Meuleman, P., Leroux-Roels, G., et al. (2012) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1206458109 · Cited by 96 · see citing works
Self-citationGlucocorticoids Modulate MicroRNA Expression and Processing during Lymphocyte Apoptosis
Smith, L. K., Shah, R., & Cidlowski, J. A. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.162123 · Cited by 94 · see citing works
Altered subcellular distribution of MSK1 induced by glucocorticoids contributes to NF‐κB inhibition
Beck, I. M. E., Berghe, W. V., Vermeulen, L., Bougarne, N., Cruyssen, B. V., Haegeman, G., & Bosscher, K. D. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.95 · Cited by 92 · see citing works
Self-citationLannan, E. A., Galliher-Beckley, A. J., Scoltock, A. B., & Cidlowski, J. A. (2012) · Endocrinology · doi:10.1210/en.2012-1020 · Cited by 91 · see citing works
Zheng, Y., Xiong, S., Jiang, P., Liu, R., Liu, X., Qian, J., Zheng, X., & Chu, Y. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.01.031 · Cited by 91 · see citing works
Molitoris, J. K., McColl, K. S., & Distelhorst, C. (2011) · Molecular Endocrinology · doi:10.1210/me.2010-0402 · Cited by 91 · see citing works
Glucocorticoids inhibitGATA‐3 phosphorylation and activity in T cells
Liberman, A. C., Druker, J., Refojo, D., Holsboer, F., & ARZT, E. S. (2009) · The FASEB Journal · doi:10.1096/fj.08-121236 · Cited by 86 · see citing works
Pearce, D., Matsui, W. H., Miner, J. N., & Yamamoto, K. R. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.46.30081 · Cited by 85 · see citing works
Selective glucocorticoid receptor modulation maintains bone mineral density in mice
Thiele, S., Ziegler, N., Tsourdi, E. A., Bosscher, K. D., Tuckermann, J. P., Hofbauer, L. C., & Rauner, M. (2012) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1688 · Cited by 85 · see citing works
Genome-wide mechanisms of nuclear receptor action
Biddie, S. C., John, S., & Hager, G. L. (2010) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2009.08.006 · Cited by 83 · see citing works
Klinge, C. M., Jernigan, S. C., Smith, S. L., Tyulmenkov, V. V., & Kulakosky, P. C. (2001) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(01)00382-3 · Cited by 82 · see citing works
So, A. Y., Cooper, S., Feldman, B. J., Manuchehri, M., & Yamamoto, K. R. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801551105 · Cited by 82 · see citing works
Dnmt1/Transcription Factor Interactions: An Alternative Mechanism of DNA Methylation Inheritance
Hervouet, É., Vallette, F. M., & Cartron, P. (2010) · Genes & Cancer · doi:10.1177/1947601910373794 · Cited by 81 · see citing works
Kabotyanski, E. B., Huetter, M., Xian, W., Rijnkels, M., & Rosen, J. M. (2006) · Molecular Endocrinology · doi:10.1210/me.2006-0160 · Cited by 79 · see citing works
Origin and functional activity of the membrane-bound glucocorticoid receptor
Strehl, C., Gaber, T., Löwenberg, M., Hommes, D. W., Verhaar, A. P., Schellmann, S., Hahne, M., Fangradt, M., Wagegg, M., Hoff, P., et al. (2011) · Arthritis & Rheumatism · doi:10.1002/art.30637 · Cited by 79 · see citing works
Potential Therapeutic Targets for Steroid-Resistant Asthma
Wang, W., Li, J. J., Foster, P. S., Hansbro, P. M., & Yang, M. (2010) · Current Drug Targets · doi:10.2174/138945010791591412 · Cited by 75 · see citing works
Transcriptional Networks Controlling Adipocyte DifferentiationPreprint
Siersbæk, R., & Mandrup, S. (2011) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2011.76.010512 · Cited by 73 · see citing works
Subramaniam, N., Cairns, W. J., & Okret, S. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.36.23567 · Cited by 71 · see citing works
Rauch, A., Gossye, V., Bracke, D., Gevaert, E., Jacques, P., Beneden, K. V., Vandooren, B., Rauner, M., Hofbauer, L. C., Haegeman, G., et al. (2011) · The FASEB Journal · doi:10.1096/fj.10-173393 · Cited by 71 · see citing works
Role for MicroRNAs in Regulating Glucocorticoid Response and Resistance in Multiple Myeloma
Tessel, M. A., Benham, A. L., Krett, N. L., Rosen, S. T., & Gunaratne, P. H. (2011) · Hormones and Cancer · doi:10.1007/s12672-011-0072-8 · Cited by 69 · see citing works
Crosstalk between TNF and glucocorticoid receptor signaling pathways
Bogaert, T. V., Bosscher, K. D., & Libert, C. (2010) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2010.04.003 · Cited by 69 · see citing works
Self-citationConway-Campbell, B. L., George, C. L., Pooley, J. R., Knight, D. M., Norman, M. R., Hager, G. L., & Lightman, S. L. (2011) · Molecular Endocrinology · doi:10.1210/me.2010-0073 · Cited by 65 · see citing works
Kabotyanski, E. B., Rijnkels, M., Freeman-Zadrowski, C., Buser, A. C., Edwards, D. P., & Rosen, J. M. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.032490 · Cited by 65 · see citing works
Tumor Necrosis Factor Inhibits Glucocorticoid Receptor Function in Mice
Bogaert, T. V., Vandevyver, S., Dejager, L., Hauwermeiren, F. V., Pinheiro, I., Πέττα, Ι., Engblom, D., Kleyman, A., Schütz, G., Tuckermann, J. P., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.212365 · Cited by 64 · see citing works
Self-citationChromatin remodeling during glucocorticoid receptor regulated transactivation
King, H. A., Trotter, K. W., & Archer, T. (2012) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2012.02.019 · Cited by 64 · see citing works
Jewell, C. M., Scoltock, A. B., Hamel, B., Yudt, M. R., & Cidlowski, J. A. (2011) · Molecular Endocrinology · doi:10.1210/me.2011-1116 · Cited by 63 · see citing works
Bhandare, R., Damera, G., Banerjee, A., Flammer, J. R., Keslacy, S., Rogatsky, I., Panettieri, R. A., Amrani, Y., & Tliba, O. (2009) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2009-0239rc · Cited by 61 · see citing works
The HAT/HDAC interplay: Multilevel control of STAT signaling
Icardi, L., Bosscher, K. D., & Tavernier, J. H. (2012) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2012.08.002 · Cited by 61 · see citing works
Self-citationDiefenbacher, M. E., Sekula, S., Heilbock, C., Maier, J. V., Litfin, M., van Dam, H., Castellazzi, M., Herrlich, P. A., & Kassel, O. (2008) · Molecular Endocrinology · doi:10.1210/me.2007-0574 · Cited by 57 · see citing works
Gross, K. L., Oakley, R. H., Scoltock, A. B., Jewell, C. M., & Cidlowski, J. A. (2011) · Molecular Endocrinology · doi:10.1210/me.2010-0051 · Cited by 56 · see citing works
Dynamic access of the glucocorticoid receptor to response elements in chromatin
George, A. A., Schiltz, R. L., & Hager, G. L. (2008) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2008.09.019 · Cited by 54 · see citing works
Rauner, M., Goettsch, C., Stein, N., Thiele, S., Bornhaeuser, M., Bosscher, K. D., Haegeman, G., Tuckermann, J. P., & Hofbauer, L. C. (2010) · Endocrinology · doi:10.1210/en.2010-0456 · Cited by 52 · see citing works
Lu, S., Mukkada, V. A., Mangray, S., Cleveland, K., Shillingford, N., Schorl, C., Brodsky, A. S., & Resnick, M. B. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040676 · Cited by 51 · see citing works
Mechanism of Interaction between the Glucocorticoid Receptor and Stat5: Role of DNA-Binding
Lechner, J., Welte, T., & Doppler, W. (1997) · Immunobiology · doi:10.1016/s0171-2985(97)80032-0 · Cited by 48 · see citing works
van Tilborg, M. A. A., Lefstin, J. A., Kruiskamp, M., Teuben, J.-M., Boelens, R., Yamamoto, K. R., & Kaptein, R. (2000) · Journal of Molecular Biology · doi:10.1006/jmbi.2000.4001 · Cited by 46 · see citing works
The mislabelling of deoxycorticosterone: making sense of corticosteroid structure and function
Vinson, G. P. (2011) · Journal of Endocrinology · doi:10.1530/joe-11-0178 · Cited by 46 · see citing works
Glucocorticoid receptor mutants: man-made tools for functional research
Beck, I. M. E., Bosscher, K. D., & Haegeman, G. (2011) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2011.03.009 · Cited by 44 · see citing works
Self-citationEpigenetic Architecture and miRNA: Reciprocal Regulators
Wiklund, E. D., Kjems, J., & Clark, S. J. (2010) · Epigenomics · doi:10.2217/epi.10.51 · Cited by 43 · see citing works
The c-fos serum response element (SRE) confers negative response to glucocorticoids.
Karagianni, N., & Tsawdaroglou, N. H. (1994) · PubMed · Cited by 43 · see citing works
Ray, A., LaForge, K. S., & Sehgal, P. B. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.16.7086 · Cited by 42 · see citing works
Martino, M. U. D., Alesci, S., Chrousos, G. P., & Kino, T. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1321.006 · Cited by 40 · see citing works
Bain, D. L., Yang, Q., Connaghan, K. D., Robblee, J. P., Miura, M. T., DeGala, G. D., Lambert, J. R., & Maluf, N. K. (2012) · Journal of Molecular Biology · doi:10.1016/j.jmb.2012.06.005 · Cited by 39 · see citing works
Engel, K. B., & Yamamoto, K. R. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.05351-11 · Cited by 37 · see citing works
Intracellular Molecular Signaling
Liberman, A. C., Druker, J., Aprile-Garcia, F., Holsboer, F., & ARZT, E. S. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2008.03958.x · Cited by 34 · see citing works
Díaz‐Gallardo, M. Y., Cote-Vélez, A., Charli, J., & Joseph‐Bravo, P. (2010) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2010.01966.x · Cited by 30 · see citing works
Wu, J., Yu, L., Dietz, J. D., & Lala, D. S. (2003) · Molecular Endocrinology · doi:10.1210/me.2002-0373 · Cited by 27 · see citing works
Glucocorticoid and Growth Factor Synergism Requirement for Notch4 Chromatin Domain Activation
Wu, J., & Bresnick, E. H. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.02152-06 · Cited by 27 · see citing works
A Composite Hormone Response Element Regulates Transcription of the Rat GHRH Receptor Gene
Nogami, H., Hiraoka, Y., Matsubara, M., Nonobe, E., Harigaya, T., Katayama, M., Hemmi, N., Kobayashi, S., Mogi, K., Aiso, S., et al. (2002) · Endocrinology · doi:10.1210/endo.143.4.8710 · Cited by 26 · see citing works
Hollenberg, S. M., Giguère, V., & Evans, R. M. (1989) · PubMed · Cited by 23 · see citing works
Flick, M. B., Sapi, E., & Kacinski, B. M. (2002) · Journal of Cellular Biochemistry · doi:10.1002/jcb.10102.abs · Cited by 22 · see citing works
Identification of microRNAs as a potential novel regulatory mechanism in HSD11B1 expression
Han, Y., Staab-Weijnitz, C. A., Xiong, G., & Maser, E. (2012) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2012.09.005 · Cited by 21 · see citing works
Diefenbacher, M. E., Litfin, M., Herrlich, P. A., & Kassel, O. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.02.010 · Cited by 19 · see citing works
Latchoumanin, O., Mynard, V., Leclerc, J., Dugué, M.-A., BERTAGNA, X. Y., & CATELLI, M. G. (2006) · Endocrinology · doi:10.1210/en.2006-0460 · Cited by 15 · see citing works
Möhnle, P., Ledderose, C., Briegel, J., & Kreth, S. (2012) · Critical Care · doi:10.1186/cc11786 · Cited by 13 · see citing works
Li, R., Guo, W., Gu, J., Zhang, M. Q., & Wang, X. (2012) · Genomics · doi:10.1016/j.ygeno.2012.07.009 · Cited by 5 · see citing works
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Immune regulation by glucocorticoids
Cain, D. W., & Cidlowski, J. A. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2017.1 · Cited by 1,846 · see citing works
Therapeutic Mechanisms of Glucocorticoids
Vandewalle, J., Luypaert, A., Bosscher, K. D., & Libert, C. (2017) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2017.10.010 · Cited by 554 · see citing works
Self-citationMolecular regulations of circadian rhythm and implications for physiology and diseases
Fagiani, F., Marino, D. D., Romagnoli, A., Travelli, C., Voltan, D., Mannelli, L. D. C., Racchi, M., Govoni, S. M., & Lanni, C. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-00899-y · Cited by 487 · see citing works
Interleukin-1 Beta—A Friend or Foe in Malignancies?
Bent, R., Moll, L., Grabbe, S., & Bros, M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19082155 · Cited by 451 · see citing works
A users guide to HPA axis research
Spencer, R. L., & Terrence Deak, B. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.11.014 · Cited by 408 · see citing works
Glucocorticoids—All-Rounders Tackling the Versatile Players of the Immune System
Strehl, C., Ehlers, L., Gaber, T., & Buttgereit, F. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01744 · Cited by 308 · see citing works
Chronic stress and glucocorticoids: From neuronal plasticity to neurodegeneration
Vyas, S., Rodrigues, A. J., Silva, J. M., Tronche, F., Almeida, O. F. X., Sousa, N., & Sotiropoulos, I. (2016) · Neural Plasticity · doi:10.1155/2016/6391686 · Cited by 297 · see citing works
McEwen, B. S., Gray, J. D., & Nasca, C. (2015) · Journal of Endocrinology · doi:10.1530/joe-15-0121 · Cited by 253 · see citing works
Rafacho, A., Ortsäter, H., Nadal, A., & Quesada, I. (2014) · Journal of Endocrinology · doi:10.1530/joe-14-0373 · Cited by 216 · see citing works
Immune regulation by glucocorticoids can be linked to cell type–dependent transcriptional responses
Franco, L. M., Gadkari, M., Howe, K. N., Sun, J., Kardava, L., Kumar, P., Kumari, S., Hu, Z., Fraser, I. D. C., Moir, S. L., et al. (2019) · The Journal of Experimental Medicine · doi:10.1084/jem.20180595 · Cited by 194 · see citing works
Argentieri, M. A., Nagarajan, S., Seddighzadeh, B., Baccarelli, A., & Shields, A. E. (2017) · EBioMedicine · doi:10.1016/j.ebiom.2017.03.044 · Cited by 189 · see citing works
Regulatory and Mechanistic Actions of Glucocorticoids on T and Inflammatory Cells
Liberman, A. C., Budziñski, M. L., Sokn, C., Gobbini, R. P., Steininger, A., & ARZT, E. S. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00235 · Cited by 185 · see citing works
Direct GR Binding Sites Potentiate Clusters of TF Binding across the Human Genome
Vockley, C. M., D’Ippolito, A. M., McDowell, I. C., Majoros, W. H., Safi, A., Song, L., Crawford, G. E., & Reddy, T. E. (2016) · Cell · doi:10.1016/j.cell.2016.07.049 · Cited by 182 · see citing works
Retinoic Acid Actions through Mammalian Nuclear Receptors
Huang, P., Chandra, V., & Rastinejad, F. (2013) · Chemical Reviews · doi:10.1021/cr400161b · Cited by 167 · see citing works
Adrenal function and dysfunction in critically ill patients
Téblick, A., Peeters, B., Langouche, L., & den Berghe, G. V. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0185-7 · Cited by 156 · see citing works
New Insights in Glucocorticoid Receptor Signaling—More Than Just a Ligand-Binding Receptor
Scheschowitsch, K., Leite, J. A., & Assreuy, J. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00016 · Cited by 155 · see citing works
Glucocorticoid Signaling: An Update from a Genomic Perspective
Sacta, M. A., Chinenov, Y. V., & Rogatsky, I. (2015) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021115-105323 · Cited by 150 · see citing works
Mechanisms of cortisol action in fish hepatocytes
Faught, E. L., & Vijayan, M. M. (2016) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/j.cbpb.2016.06.012 · Cited by 149 · see citing works
Roy, B., Shelton, R. C., & Dwivedi, Y. (2017) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2017.02.005 · Cited by 139 · see citing works
BaHammam, A. S., & Pirzada, R. (2023) · Clocks & Sleep · doi:10.3390/clockssleep5030034 · Cited by 138 · see citing works
The Glucocorticoid Receptor: Isoforms, Functions, and Contribution to Glucocorticoid Sensitivity
Lockett, J., Inder, W. J., & Clifton, V. L. (2024) · Endocrine Reviews · doi:10.1210/endrev/bnae008 · Cited by 135 · see citing works
Voisin, M., de Médina, P., Mallinger, A., Dalenc, F., Huc‐Claustre, E., Leignadier, J., Serhan, N., Soulès, R., Segala, G., Mougel, A., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1707965114 · Cited by 135 · see citing works
Glucocorticoids, genes and brain function
Juszczak, G. R., & Stankiewicz, A. M. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.11.020 · Cited by 135 · see citing works
Stress and the dynamic genome: Steroids, epigenetics, and the transposome
Hunter, R. G., Gagnidze, K., McEwen, B. S., & Pfaff, D. W. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1411260111 · Cited by 133 · see citing works
Hypothalamic-pituitary – adrenal axis-feedback control
Keller‐Wood, M. (2015) · Comprehensive Physiology · doi:10.1002/cphy.c140065 · Cited by 131 · see citing works
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Massafra, V., Pellicciari, R., Gioiello, A., & van Mil, S. W. C. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.06.009 · Cited by 129 · see citing works
Genome reading by the NF-κB transcription factors
Mulero, M. C., Wang, V. Y., Huxford, T., & Ghosh, G. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz739 · Cited by 127 · see citing works
Johnson, F. K., & Kaffman, A. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.06.008 · Cited by 124 · see citing works
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Vandewalle, J., & Libert, C. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01318 · Cited by 123 · see citing works
Self-citationAlam, M. M., Okazaki, K., Nguyen, L. T. T., Ota, N., Kitamura, H., Murakami, S., Shima, H., Igarashi, K., Sekine, H., & Motohashi, H. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.773960 · Cited by 122 · see citing works
Hormonal control of T-cell development in health and disease
Savino, W., Mendes‐da‐Cruz, D. A., Lepletier, A., & Dardenne, M. (2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.168 · Cited by 121 · see citing works
Glucocorticoids Regulate Circadian Rhythm of Innate and Adaptive Immunity
Shimba, A., & Ikuta, K. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.02143 · Cited by 121 · see citing works
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Ren, B., & Zhu, Y. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052708 · Cited by 121 · see citing works
Liu, J., Buisman-Pijlman, F., & Hutchinson, M. R. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00309 · Cited by 119 · see citing works
Starick, S. R., Ibn-Salem, J., Jurk, M., Hernandez, C., Love, M. I., Chung, H., Vingron, M., Thomas‐Chollier, M., & Meijsing, S. H. (2015) · Genome Research · doi:10.1101/gr.185157.114 · Cited by 120 · see citing works
Rodrigues, M. E. D. S., Bekhbat, M., Houser, M. C., Chang, J., Walker, D. I., Jones, D. P., do Nascimento, C. M. P. O., Barnum, C. J., & Tansey, M. G. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.08.021 · Cited by 119 · see citing works
Endothelial Response to Glucocorticoids in Inflammatory Diseases
Zielińska, K. A., Moortel, L. V., Opdenakker, G., Bosscher, K. D., & den Steen, P. E. V. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00592 · Cited by 116 · see citing works
The Pro-inflammatory Effects of Glucocorticoids in the Brain
Duque, É. D. A., & Munhoz, C. D. (2016) · Frontiers in Endocrinology · doi:10.3389/fendo.2016.00078 · Cited by 115 · see citing works
Spencer, R. L., Chun, L. E., Hartsock, M. J., & Woodruff, E. R. (2017) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2017.12.005 · Cited by 113 · see citing works
Xie, Y., Tolmeijer, S. H., Oskam, J. M., Tonkens, T., Meijer, A. H., & Schaaf, M. J. M. (2019) · Disease Models & Mechanisms · doi:10.1242/dmm.037887 · Cited by 112 · see citing works
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Buchholz, D. R. (2015) · Developmental Biology · doi:10.1016/j.ydbio.2015.02.018 · Cited by 105 · see citing works
DuPont, J. J., McCurley, A., Davel, A. P., McCarthy, J., Bender, S. B., Hong, K., Yang, Y., Yoo, J., Aronovitz, M. J., Baur, W. E., et al. (2016) · JCI Insight · doi:10.1172/jci.insight.88942 · Cited by 105 · see citing works
Defining the role of glucocorticoids in inflammation
Ronchetti, S., Migliorati, G., Bruscoli, S., & Riccardi, C. (2018) · Clinical Science · doi:10.1042/cs20171505 · Cited by 102 · see citing works
Steroids and endocrine disruptors—History, recent state of art and open questions
Hampl, R., Kubátová, J., & Stárka, L. (2014) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2014.04.013 · Cited by 97 · see citing works
Kemenade, B. M. L. V.-V., Cohen, N., & Chadzińska, M. (2016) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2016.05.015 · Cited by 96 · see citing works
Voutsadakis, I. A. (2016) · Journal of Clinical Medicine · doi:10.3390/jcm5010011 · Cited by 94 · see citing works
Vamorolone targets dual nuclear receptors to treat inflammation and dystrophic cardiomyopathy
Heier, C. R., Yu, Q., Fiorillo, A. A., Tully, C., Tucker, A., Mázala, D. A. G., Uaesoontrachoon, K., Srinivassane, S., Damsker, J. M., Hoffman, E. P., et al. (2019) · Life Science Alliance · doi:10.26508/lsa.201800186 · Cited by 92 · see citing works
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Lee, R. A., Harris, C. A., & Wang, J.-C. (2018) · Nuclear Receptor Research · doi:10.32527/2018/101373 · Cited by 92 · see citing works
Morris, G., Berk, M., Maes, M. H. J., Carvalho, A. F., & Puri, B. K. (2019) · Molecular Neurobiology · doi:10.1007/s12035-019-1498-1 · Cited by 87 · see citing works
Glucocorticoid resistance as a major drive in sepsis pathology
Dendoncker, K., & Libert, C. (2017) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2017.04.002 · Cited by 85 · see citing works
Self-citationHua, G., Ganti, K. P., & Chambon, P. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1522826113 · Cited by 84 · see citing works
Hua, G., Paulen, L., & Chambon, P. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1522821113 · Cited by 84 · see citing works
Cistrome of the aldosterone-activated mineralocorticoid receptor in human renal cells
Billan, F. L., Khan, J. A., Lamribet, K., Viengchareun, S., Bouligand, J., Fagart, J., & Lombès, M. (2015) · The FASEB Journal · doi:10.1096/fj.15-274266 · Cited by 82 · see citing works
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Lemche, E. (2018) · Current Genomics · doi:10.2174/1389202919666171229145156 · Cited by 82 · see citing works
Oxysterols and nuclear receptors
Ma, L., & Nelson, E. R. (2019) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2019.01.016 · Cited by 81 · see citing works
Pan-Vazquez, A., Rye, N., Ameri, M., McSparron, B., Smallwood, G., Bickerdyke, J., Rathbone, A., Dajas‐Bailador, F., & Toledo‐Rodriguez, M. (2015) · Molecular Brain · doi:10.1186/s13041-015-0128-8 · Cited by 80 · see citing works
New insights into the novel anti-inflammatory mode of action of glucocorticoids
Ingawale, D. K., & Mandlik, S. K. (2020) · Immunopharmacology and Immunotoxicology · doi:10.1080/08923973.2020.1728765 · Cited by 78 · see citing works
Harris, B. N. (2019) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2019.113355 · Cited by 76 · see citing works
Thambirajah, A. A., Wade, M. G., Jonathan Verreault, A., Buisine, N., Alves, V. A., Langlois, V. S., & Helbing, C. C. (2021) · Environmental Research · doi:10.1016/j.envres.2021.111906 · Cited by 76 · see citing works
Regulation of TRH neurons and energy homeostasis-related signals under stress
Joseph‐Bravo, P., Jaimes-Hoy, L., & Charli, J. (2015) · Journal of Endocrinology · doi:10.1530/joe-14-0593 · Cited by 76 · see citing works
Green, M. R., & McCormick, C. M. (2016) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2016.02.004 · Cited by 76 · see citing works
Weikum, E. R., de Vera, I. M. S., Nwachukwu, J. C., Hudson, W. H., Nettles, K. W., Kojetin, D. J., & Ortlund, E. A. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx509 · Cited by 76 · see citing works
Prenek, L., Boldizsár, F., Kugyelka, R., Ugor, E., Berta, G., Németh, P., & Berki, T. (2016) · APOPTOSIS · doi:10.1007/s10495-016-1320-8 · Cited by 75 · see citing works
Maternal stress and fish reproduction: The role of cortisol revisited
Faught, E. L., & Vijayan, M. M. (2018) · Fish and Fisheries · doi:10.1111/faf.12309 · Cited by 73 · see citing works
Roles of the Glucocorticoid and Mineralocorticoid Receptors in Skin Pathophysiology
Sevilla, L. M., & Pérez, P. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19071906 · Cited by 72 · see citing works
Sevilla, L. M., Jiménez‐Panizo, A., Alegre‐Martí, A., Estébanez‐Perpiñá, E., Caelles, C., & Pérez, P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221810049 · Cited by 72 · see citing works
Lesovaya, E. A., Yemelyanov, A. Y., Swart, A. C., Swart, P., Haegeman, G., & Budunova, I. V. (2015) · Oncotarget · doi:10.18632/oncotarget.5078 · Cited by 72 · see citing works
Chromatin recruitment of activated AMPK drives fasting response genes co-controlled by GR and PPARα
Ratman, D., Mylka, V., Bougarne, N., Pawlak, M., Caron, S., Hennuyer, N., Paumelle, R., Cauwer, L. D., Thommis, J., Rider, M. H., et al. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw742 · Cited by 70 · see citing works
Self-citationA Body Shape Index (ABSI), hip index, and risk of cancer in the UK Biobank cohort
Christakoudi, S., Tsilidis, K. K., Εvangelou, Ε., & Ríboli, E. (2021) · Cancer Medicine · doi:10.1002/cam4.4097 · Cited by 70 · see citing works
Rummel, C. D. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.09.003 · Cited by 70 · see citing works
Role of microRNAs in Immune Regulation with Translational and Clinical Applications
Gaál, Z. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25031942 · Cited by 69 · see citing works
Comparing the rules of engagement of androgen and glucocorticoid receptors
Claessens, F., Joniau, S., & Helsen, C. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2467-3 · Cited by 69 · see citing works
Glucocorticoid receptor function in health and disease
Caratti, G., Matthews, L. C., Poolman, T. M., Kershaw, S., Baxter, M. D., & Ray, D. W. (2015) · Clinical Endocrinology · doi:10.1111/cen.12728 · Cited by 68 · see citing works
Glucocorticoids promote apoptosis of proinflammatory monocytes by inhibiting ERK activity
Achuthan, A. A., Aslam, A. S. M., Nguyen, Q., Lam, P. Y., Fleetwood, A. J., Frye, A. T., Louis, C., Lee, M.-C., Smith, J. E., Cook, A. D., et al. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0332-4 · Cited by 67 · see citing works
Blum, S., & McCombe, P. (2014) · Journal of the Peripheral Nervous System · doi:10.1111/jns5.12074 · Cited by 66 · see citing works
Glucocorticoid receptor quaternary structure drives chromatin occupancy and transcriptional outcomePreprint
Paakinaho, V., Johnson, T. A., Presman, D. M., & Hager, G. L. (2019) · Genome Research · doi:10.1101/gr.244814.118 · Cited by 66 · see citing works
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Bosscher, K. D., Beck, I. M. E., Ratman, D., Berghe, W. V., & Libert, C. (2015) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2015.09.002 · Cited by 65 · see citing works
Self-citationWiley, J. W., Higgins, G. A., & Athey, B. D. (2015) · Neurogastroenterology & Motility · doi:10.1111/nmo.12706 · Cited by 65 · see citing works
Pleiotropic Effects of Glucocorticoids on the Immune System in Circadian Rhythm and Stress
Shimba, A., Ejima, A., & Ikuta, K. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.706951 · Cited by 64 · see citing works
Baida, G. E., Bhalla, P., Игоревич, К. К., Lesovaya, E. A., Геннадиевна, Я. М., Yuen, K., Guo, S., Lavker, R. M., Readhead, B., Dudley, J. T., et al. (2014) · EMBO Molecular Medicine · doi:10.15252/emmm.201404601 · Cited by 64 · see citing works
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Klepsch, V., Moschen, A. R., Tilg, H., Baier, G., & Hermann‐Kleiter, N. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01070 · Cited by 63 · see citing works
Duality of glucocorticoid action in cancer: tumor-suppressor or oncogene?
Mayayo‐Peralta, I., Zwart, W. T., & Preković, S. (2021) · Endocrine Related Cancer · doi:10.1530/erc-20-0489 · Cited by 63 · see citing works
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Cannarile, L., Delfino, D. V., Adorisio, S., Riccardi, C., & Ayroldi, E. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01823 · Cited by 62 · see citing works
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Giulbudagian, M., Hönzke, S., Bergueiro, J., Işık, D., Schumacher, F., Saeidpour, S., Lohan, S. B., Meinke, M. C., Teutloff, C., Schäfer‐Korting, M., et al. (2017) · Nanoscale · doi:10.1039/c7nr04480a · Cited by 61 · see citing works
Zhao, X.-F. (2020) · Cell Communication and Signaling · doi:10.1186/s12964-020-00620-y · Cited by 60 · see citing works
Ugor, E., Prenek, L., Pap, R., Berta, G., Ernszt, D., Najbauer, J., Németh, P., Boldizsár, F., & Berki, T. (2017) · Immunobiology · doi:10.1016/j.imbio.2017.10.010 · Cited by 58 · see citing works
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Hübner, S., Dejager, L., Libert, C., & Tuckermann, J. P. (2015) · Biological Chemistry · doi:10.1515/hsz-2015-0106 · Cited by 57 · see citing works
Self-citationJubb, A. W., Young, R. S., Hume, D. A., & Bickmore, W. A. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1502009 · Cited by 57 · see citing works
Hu, S., Xia, L., Luo, H., Xu, Y., Yu, H., Xu, D., & Wang, H. (2019) · Toxicology · doi:10.1016/j.tox.2019.02.008 · Cited by 55 · see citing works
Dulek, D. E., Fuhlbrigge, R. C., Tribble, A. C., Connelly, J. A., Loi, M. M., Chebib, H. E., Chandrakasan, S., Otto, W. R., Diorio, C. J., Keim, G. P., et al. (2020) · Journal of the Pediatric Infectious Diseases Society · doi:10.1093/jpids/piaa098 · Cited by 55 · see citing works
Harding, T., Baughn, L. B., Kumar, S. K., & Ness, B. V. (2019) · Leukemia · doi:10.1038/s41375-018-0362-z · Cited by 54 · see citing works
Mechanisms of Glucocorticoid-Regulated Gene Transcription
Meijsing, S. H. (2015) · Advances in experimental medicine and biology · doi:10.1007/978-1-4939-2895-8_3 · Cited by 53 · see citing works
Dexamethasone enhances the lung metastasis of breast cancer via a PI3K-SGK1-CTGF pathway
Zhang, Y., Shi, G., Zhang, H., Xiong, Q., Cheng, F., Wang, H., Luo, J., Zhang, Y., Shi, P., Xu, J., et al. (2021) · Oncogene · doi:10.1038/s41388-021-01944-w · Cited by 53 · see citing works
He, M., Halima, M., Xie, Y., Schaaf, M. J. M., Meijer, A. H., & Wang, M. (2020) · Cells · doi:10.3390/cells9051107 · Cited by 52 · see citing works
Regulation of the Immune System Development by Glucocorticoids and Sex Hormones
Quatrini, L., Ricci, B., Ciancaglini, C., Tumino, N., & Moretta, L. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.672853 · Cited by 51 · see citing works
The Acute Stress Response in the Multiomic Era
Floriou-Servou, A., von Ziegler, L., Waag, R., Schläppi, C., Germain, P.-L., & Bohacek, J. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.12.031 · Cited by 51 · see citing works
Cellular stress mechanisms of prenatal maternal stress: Heat shock factors and oxidative stress
Dowell, J., Elser, B. A., Schroeder, R. E., & Stevens, H. E. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.134368 · Cited by 50 · see citing works
Ballester, M., Ramayo‐Caldas, Y., Revilla, M., Corominas, J., Castelló, A., Estellé, J., Fernández, A. I., & Folch, J. M. (2017) · Scientific Reports · doi:10.1038/srep46539 · Cited by 49 · see citing works
Genome-wide fetalization of enhancer architecture in heart disease
Spurrell, C. H., Barozzi, I., Kosicki, M., Mannion, B. J., Blow, M. J., Fukuda-Yuzawa, Y., Slaven, N., Afzal, S. Y., Akiyama, J. A., Afzal, V., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111400 · Cited by 48 · see citing works
Glucocorticoid-targeted therapies for the treatment of rheumatoid arthritis
Strehl, C., van der Goes, M. C., Bijlsma, J. W. J., Jacobs, J. W. G., & Buttgereit, F. (2017) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2017.1276562 · Cited by 46 · see citing works
- Authors
- Ratman, D., Vanden Berghe, W., Dejager, L., Libert, C., Tavernier, J., Beck, I. M., & De Bosscher, K.
- Affiliations
- Ghent University (BE)
- Ghent University Hospital (BE)
- Venue
- Molecular and Cellular Endocrinology
- Publisher
- Elsevier BV
- Published
- 2013-11
- Volume
- 380
- Issue
- 1-2
- Pages
- 41-54
- ISSN
- 0303-7207 (ISSN-L)
- OpenAlex
- W2067181732
- Cited by
- 411
- References
- 174
- Citations by year
- 2026: 17 · 2025: 16 · 2024: 17 · 2023: 25 · 2022: 34 · 2021: 30 · 2020: 30 · 2019: 51 · 2018: 46 · 2017: 45 · 2016: 36 · 2015: 35 · 2014: 22 · 2013: 7
- FWCI
- 2.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular and Cellular Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- Funders
- Fonds Wetenschappelijk Onderzoek
- Universiteit Antwerpen
- Vlaamse regering
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- glucocorticoid receptor, transrepression, transcription factor regulation, protein-protein interaction, glucocorticoid response element, glucocorticoid signaling, inflammatory diseases, glucocorticoid adverse effects, nuclear receptors
- MeSH terms
- Animals, Chromatin, Humans, Protein Kinases, Protein Processing, Post-Translational, Receptors, Glucocorticoid, Transcription Factors, Transcriptional Activation, Response Elements, Epigenetic Repression
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