CoChat
Sign Up
Cited by 149

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

Growth Factor-Induced Tyrosine Phosphorylation of Hrs, a Novel 115-Kilodalton Protein with a Structurally Conserved Putative Zinc Finger Domain

Komada, Masayuki, Kitamura, Naomi·1995·Molecular and Cellular Biology
DOI 10.1128/mcb.15.11.6213
Open this paper in CoChat — free account

Abstract

The activation of growth factor receptor tyrosine kinases leads to tyrosine phosphorylation of many intracellular proteins which are thought to play crucial roles in growth factor signaling pathways. We previously showed that tyrosine phosphorylation of a 115-kDa protein is rapidly induced in cells treated with hepatocyte growth factor. To clarify the structure and possible function of the 115-kDa protein (designated Hrs for hepatocyte growth factor-regulated tyrosine kinase substrate), we purified this protein from B16-F1 mouse melanoma cells by anti-phosphotyrosine immunoaffinity chromatography and determined its partial amino acid sequences. On the basis of the amino acid sequences, we molecularly cloned the cDNA for mouse Hrs. The nucleotide sequence of the cDNA revealed that Hrs is a novel 775-amino-acid protein with a putative zinc finger domain that is structurally conserved in several other proteins. This protein also contained a proline-rich region and a proline- and glutamine-rich region. The expression of Hrs mRNA was detected in all adult mouse tissues tested and also in embryos. To analyze the Hrs cDNA product, we prepared a polyclonal antibody against bacterially expressed Hrs. Using this antibody, we showed by subcellular fractionation that Hrs is localized to the cytoplasm; we also showed that that tyrosine phosphorylation of Hrs is induced in cells treated with epidermal growth factor or platelet-derived growth factor. These results suggest that Hrs plays a u…

Overview

Integrity signals

Registry

Crossref · 10.1128/mcb.15.11.6213

Cites

3 of 3 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 69

  1. 10.1016/S0021-9258(18)82042-7 · DOI
  2. 10.1126/science.1846706 · DOI
  3. 10.1016/0092-8674(91)90639-G · DOI
  4. 10.1016/0006-291X(92)91706-V · DOI
  5. 10.1038/362549a0 · DOI
  6. 10.1126/science.2466336 · DOI
  7. 10.1002/j.1460-2075.1993.tb05735.x · DOI
  8. 10.1016/0092-8674(91)90638-F · DOI
  9. 10.1016/0092-8674(92)90444-H · DOI
  10. 10.1002/j.1460-2075.1993.tb06058.x · DOI
  11. 10.1128/mcb.13.9.5814-5828.1993 · DOI
  12. 10.1073/pnas.91.22.10655 · DOI
  13. 10.1073/pnas.86.15.5844 · DOI
  14. 10.1073/pnas.90.2.649 · DOI
  15. 10.1172/JCI113334 · DOI
  16. 10.1038/337749a0 · DOI
  17. 10.1073/pnas.90.5.1937 · DOI
  18. 10.1016/S0021-9258(18)54536-1 · DOI
  19. 10.1128/mcb.14.7.4749-4758.1994 · DOI
  20. 10.1073/pnas.91.9.3584 · DOI
  21. 10.1016/0092-8674(93)90664-C · DOI
  22. 10.1016/0006-291X(91)90524-B · DOI
  23. 10.1128/mcb.11.2.713-720.1991 · DOI
  24. 10.1016/0092-8674(90)90220-9 · DOI
  25. 10.1016/0092-8674(89)90510-2 · DOI
  26. 10.1126/science.2157284 · DOI
  27. 10.1016/0968-0004(90)90073-K · DOI
  28. 10.1073/pnas.91.10.4170 · DOI
  29. 10.1016/0968-0004(87)90231-3 · DOI
  30. 10.1126/science.1708916 · DOI
  31. Komada M., 1993, Oncogene, 8, 2381
  32. 10.1016/S0021-9258(17)33982-0 · DOI
  33. 10.1111/j.1432-1033.1992.tb16705.x · DOI
  34. 10.1093/nar/15.20.8125 · DOI
  35. 10.1128/mcb.12.12.5824-5833.1992 · DOI
  36. 10.1016/0092-8674(89)90047-0 · DOI
  37. 10.1073/pnas.88.13.5729 · DOI
  38. 10.1016/0092-8674(89)90048-2 · DOI
  39. 10.1126/science.2667136 · DOI
  40. 10.1016/0092-8674(91)90363-4 · DOI
  41. 10.1002/j.1460-2075.1993.tb05879.x · DOI
  42. 10.1016/0092-8674(89)90100-1 · DOI
  43. 10.1074/jbc.270.22.13503 · DOI
  44. 10.1002/j.1460-2075.1991.tb07836.x · DOI
  45. 10.1006/bbrc.1993.1125 · DOI
  46. 10.1073/pnas.86.13.4868 · DOI
  47. 10.1128/mcb.12.12.5816-5823.1992 · DOI
  48. 10.1073/pnas.84.18.6379 · DOI
  49. 10.1016/0092-8674(94)90552-5 · DOI
  50. 10.1016/0092-8674(92)90536-L · DOI
  51. 10.1016/0092-8674(94)90318-2 · DOI
  52. 10.1126/science.8438166 · DOI
  53. 10.1128/mcb.12.11.5152-5158.1992 · DOI
  54. 10.1073/pnas.86.18.6940 · DOI
  55. 10.1073/pnas.88.2.415 · DOI
  56. 10.1016/0168-9525(94)90034-5 · DOI
  57. 10.1016/0092-8674(94)90191-0 · DOI
  58. 10.1016/0092-8674(93)90404-E · DOI
  59. 10.1002/jcp.1041390316 · DOI
  60. 10.1038/327239a0 · DOI
  61. 10.1172/JCI115207 · DOI
  62. 10.1016/0092-8674(90)90801-K · DOI · Paper page
  63. 10.1038/342699a0 · DOI
  64. 10.1083/jcb.111.5.2097 · DOI
  65. 10.1083/jcb.121.1.145 · DOI
  66. 10.1016/S0021-9258(18)48539-0 · DOI
  67. 10.1021/bi00409a001 · DOI
  68. 10.1016/0092-8674(94)90367-0 · DOI
  69. 10.1016/S0021-9258(18)43972-5 · DOI

Cited by

Sorted by citations

Metadata

Authors
Komada, M., & Kitamura, N.
Affiliations
Institute for Liver Research, Kansai Medical University, Moriguchi, Osaka 570, Japan
Venue
Molecular and Cellular Biology
Publisher
Informa UK Limited
Published
1995-11-01
Volume
15
Issue
11
Pages
6213-6221
ISSN
1098-5549
DOI
10.1128/mcb.15.11.6213
Cited by
149
References
3
Language
en
Licence
journals.asm.org/non-commercial-tdm-license (tdm)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review