The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Calcium Activates Serum Response Factor-Dependent Transcription By A Ras- and Elk-1-Independent Mechanism That Involves a Ca2+/Calmodulin-Dependent Kinase
Open accessAbstract
Enhanced levels of cytoplasmic Ca2+ due to membrane depolarization with elevated levels of KCl or exposure to the Ca2+ ionophore ionomycin stimulate serum response element (SRE)-dependent transcription in the pheochromocytoma cell line PC12. By using altered binding specificity mutants of transcription factors that bind to the SRE, it was demonstrated that in contrast to treatment with purified growth factors, such as nerve growth factor, the serum response factor (SRF), but not Elk-1, mediates Ca(2+)-regulated SRE-dependent transcription. Enhanced levels of cytoplasmic Ca2+ were found to trigger SRE-dependent transcription via a Ras-independent signaling pathway that appears to involve a Ca2+/calmodulin-dependent kinase (CaMK). Overexpression of a constitutively active form of CaMKIV stimulated SRF-dependent transcription. Taken together, these findings indicate that SRF is a versatile transcription factor that, when bound to the SRE, can function by distinct mechanisms and can mediate transcriptional responses to both CaMK- and Ras-dependent signaling pathways.
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Citations
Cites
Regulation of Gene Expression in Hippocampal Neurons by Distinct Calcium Signaling Pathways
Bading, H., Ginty, D. D., & Greenberg, M. E. (1993) · Science · doi:10.1126/science.8097060 · Cited by 1,157
Self-citation
Cited by
Whitmarsh, A. J., & Davis, R. J. (1996) · Journal of Molecular Medicine · doi:10.1007/s001090050063 · Cited by 1,543
Nerve Growth Factor Signaling, Neuroprotection, and Neural Repair
Sofroniew, M. V., Howe, C. L., & Mobley, W. C. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.1217 · Cited by 1,284
Coupling of the RAS-MAPK Pathway to Gene Activation by RSK2, a Growth Factor-Regulated CREB Kinase
Xing, J., Ginty, D. D., & Greenberg, M. E. (1996) · Science · doi:10.1126/science.273.5277.959 · Cited by 1,248
Self-citationCa2+/CaM-Dependent Kinases: From Activation to Function
Hook, S. S., & Means, A. R. (2001) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.41.1.471 · Cited by 482
Role of p38 and JNK Mitogen-Activated Protein Kinases in the Activation of Ternary Complex Factors
Whitmarsh, A. J., Yang, S.-H., Su, M. S.-S., Sharrocks, A. D., & Davis, R. J. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.5.2360 · Cited by 455
Metadata
- Authors
- Miranti, C. K., Ginty, D. D., Huang, G., Chatila, T., & Greenberg, M. E.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 1995-07-01
- Volume
- 15
- Issue
- 7
- Pages
- 3672-3684
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W2100338501
- Cited by
- 216
- References
- 1
- FWCI
- 7.70
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Calcium Activates Serum Response Factor-Dependent Transcription By A Ras- and Elk-1-Independent Mechanism That Involves a Ca2+/Calmodulin-Dependent Kinase. https://app.cochat.ai/papers/10.1128/mcb.15.7.3672
- The paper
- Miranti, C. K., Ginty, D. D., Huang, G., Chatila, T., & Greenberg, M. E. (1995). Calcium Activates Serum Response Factor-Dependent Transcription By A Ras- and Elk-1-Independent Mechanism That Involves a Ca2+/Calmodulin-Dependent Kinase. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.15.7.3672
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