Activation and Association of Stat3 with Src in v-Src-Transformed Cell Lines

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A novel role for c-Src and STAT3 in apoptotic cell–mediated MerTK-dependent immunoregulation of dendritic cells

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Functional Uncoupling of the Janus Kinase 3-Stat5 Pathway in Malignant Growth of Human T Cell Leukemia Virus Type 1-Transformed Human T Cells

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The role of scaffold microarchitecture in engineering endothelial cell immunomodulation

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STAT s profiling reveals predominantly‐activated STAT3 in cholangiocarcinoma genesis and progression

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Positive feedback regulation between IL10 and EGFR promotes lung cancer formation

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Therapeutic Mechanistic Studies of ShuFengJieDu Capsule in an Acute Lung Injury Animal Model Using Quantitative Proteomics Technology

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Synergistic Signaling by Corticotropin-Releasing Hormone and Leukemia Inhibitory Factor Bridged by Phosphorylated 3′,5′-Cyclic Adenosine Monophosphate Response Element Binding Protein at the Nur Response Element (NurRE)-Signal Transducers and Activators of Transcription (STAT) Element of the Proopiomelanocortin Promoter

Mynard, V., Latchoumanin, O., Guignat, L., Leclerc, J., BERTAGNA, X. Y., Barré, B., Fagart, J., Coqueret, O., & CATELLI, M. G. (2004) · Molecular Endocrinology · doi:10.1210/me.2003-0417 · Cited by 42

Regulation of T cell homeostasis by JAKs and STATs

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Disruption of STAT3 signaling leads to tumor cell invasion through alterations of homotypic cell–cell adhesion complexes

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Protein-tyrosine Phosphatase D1, a Potential Regulator and Effector for Tec Family Kinases

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Xanthohumol inhibits STAT3 activation pathway leading to growth suppression and apoptosis induction in human cholangiocarcinoma cells

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Expression of a tyrosine phosphorylated, DNA binding Stat3β dimer in bacteria

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A Novel Function of Stat1α and Stat3 Proteins in Erythropoietin-Induced Erythroid Differentiation of a Human Leukemia Cell Line

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Structure and functional analysis of the human STAT3 gene promoter: alteration of chromatin structure as a possible mechanism for the upregulation in cisplatin-resistant cells

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STAT3 signaling is induced by intercellular adhesion in squamous cell carcinoma cells

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8-Benzyl-4-oxo-8-azabicyclo[3.2.1]oct-2-ene-6,7-dicarboxylic Acid (SD-1008), a Novel Janus Kinase 2 Inhibitor, Increases Chemotherapy Sensitivity in Human Ovarian Cancer Cells

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STAT3 acts through pre-existing nucleosome-depleted regions bound by FOS during an epigenetic switch linking inflammation to cancer

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Platelet-Endothelial Cell Adhesion Molecule-1 Regulates Endothelial NO Synthase Activity and Localization Through Signal Transducers and Activators of Transcription 3–Dependent NOSTRIN Expression

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Activation of Stat3 and Stat1 DNA binding and transcriptional activity in human brain tumour cell lines by gp130 cytokines

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STAT3 plays an important role in DNA replication by turning on WDHD1

Zhou, Y., & Chen, J. J. (2021) · Cell & Bioscience · doi:10.1186/s13578-020-00524-x · Cited by 38

ZIC2 is downregulated and represses tumor growth via the regulation of STAT3 in breast cancer

Liu, Z., Chen, M., Zhang, Q., Zhang, Y., An, X., Luo, Y., Liu, X., Liu, S., Liu, Q., Yang, T., et al. (2020) · International Journal of Cancer · doi:10.1002/ijc.32922 · Cited by 38

Signal transducers and activators of transcription 5B potentiates v-Src-mediated transformation of NIH-3T3 cells.

Kazansky, A. V., & Rosen, J. M. (2001) · PubMed · Cited by 38

Expression of a Y559F Mutant CSF-1 Receptor in M1 Myeloid Cells: A Role for Src Kinases in CSF-1 Receptor-Mediated Differentiation

Marks, D. C., Csar, X. F., Wilson, N. J., Novak, U., Ward, A. C., Kanagasundarum, V., Hoffmann, B., & Hamilton, J. A. (1999) · Molecular Cell Biology Research Communications · doi:10.1006/mcbr.1999.0123 · Cited by 38

The Src-Family Kinase Lck Can Induce STAT3 Phosphorylation and DNA Binding Activity

Lund, T. C. (1999) · Cellular Signalling · doi:10.1016/s0898-6568(99)00045-5 · Cited by 38

Regulation by Gi2 proteins of v-fms-induced proliferation and transformation via Src-kinase and STAT3

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Specific Inhibition of Stat5a/b Promotes Apoptosis of IL-2-Responsive Primary and Tumor-Derived Lymphoid Cells

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STAT1 and STAT3 do not participate in FGF-mediated growth arrest in chondrocytes

Krejčí, P., Salazar, L., Goodridge, H. S., Kashiwada, T. A., Schibler, M. J., Jelinkova, P., Thompson, L. M., & Wilcox, W. R. (2008) · Journal of Cell Science · doi:10.1242/jcs.017160 · Cited by 40

Phosphatase of Regenerating Liver 3 (PRL3) Provokes a Tyrosine Phosphoproteome to Drive Prometastatic Signal Transduction

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Signal TransductionThrough Cytokine Receptors

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Targeting STAT-3 signaling pathway in cancer for development of novel drugs: Advancements and challenges

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Topical Sunitinib ointment alleviates Psoriasis-like inflammation by inhibiting the proliferation and apoptosis of keratinocytes

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The JAK-inhibitor, JAB/SOCS-1 selectively inhibits cytokine-induced, but not v-Src induced JAK–STAT activation

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Ras pathway is required for the activation of MMP-2 secretion and for the invasion of src-transformed 3Y1

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Impact of STAT3 phosphorylation in glioblastoma stem cells radiosensitization and patient outcome

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c-Src Activates the DNA Binding and Transcriptional Activity of Stat3 Molecules: Serine 727 Is Not Required for Transcriptional Activation under Certain Circumstances

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Role of tumor suppressor genes in transplacental lung carcinogenesis

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A Prostaglandin F2α Analog Induces Suppressors of Cytokine Signaling-3 Expression in the Corpus Luteum of the Pregnant Rat: A Potential New Mechanism in Luteolysis

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Human T-cell leukemia virus type 1 Tax protein induces the expression of STAT1 and STAT5 genes in T-cells

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Expression of v-src in mammary epithelial cells induces transcription via STAT3

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Nuclear import of Pin1 is mediated by a novel sequence in the PPIase domain

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Retinoic acid increases proliferation rate of GL‐15 glioma cells, involving activation of STAT‐3 transcription factor

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17β-Estradiol-Dependent Activation of Signal Transducer and Activator of Transcription-1 in Human Fetal Osteoblasts Is Dependent on Src Kinase Activity

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Direct Binding and Activation of STAT Transcription Factors by the Herpesvirus saimiri Protein Tip

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Regulation of the trans-activation potential of STAT5 through its DNA-binding activity and interactions with heterologous transcription factors

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Potential Roles of Stat1 and Stat3 in Cellular TransformationPreprint

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MLLT11/AF1q boosts oncogenic STAT3 activity through Src-PDGFR tyrosine kinase signaling

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A deuterated analog of dasatinib disrupts cell cycle progression and displays anti‐non‐small cell lung cancer activity in vitro and in vivo

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The role of constitutively activated STAT3 in B16 melanoma cells

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Constitutive activation of Jak-2 and Tyk-2 in a v-Src-transformed human gallbladder adenocarcinoma cell line

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IL-7 Reconstitutes Multiple Aspects of v-Abl-Mediated Signaling

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Apoptosis in the Gastrointestinal Tract

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STAT5A interacts with and is phosphorylated upon activation of the µ‐opioid receptor

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Interdomain Interaction of Stat3 Regulates Its Src Homology 2 Domain-mediated Receptor Binding Activity*

Zhang, T., Seow, K., Ong, C. T., & Cao, X. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m105525200 · Cited by 32

Disarming an Electrophilic Warhead: Retaining Potency in Tyrosine Kinase Inhibitor (TKI)‐Resistant CML Lines While Circumventing Pharmacokinetic Liabilities

Ali, A. M., Gómez‐Biagi, R. F., Rosa, D. A., Lai, P., Heaton, W. L., Park, J. S., Eiring, A. M., Vellore, N. A., de Araujo, E. D., Ball, D. P., et al. (2016) · ChemMedChem · doi:10.1002/cmdc.201600021 · Cited by 27

Src and Fyn define a new signaling cascade activated by canonical and non-canonical Wnt ligands and required for gene transcription and cell invasion

Villarroel, A., del Valle‐Pérez, B., Fuertes, G., Curto, J., Ontiveros, N., de Herreros, A. G., & Duñach, M. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03221-2 · Cited by 27

Regulation of STAT3 by μ-opioid receptors in human neuroblastoma SH-SY5Y cells

Yuen, J. W.-F., So, I. Y. W., Kam, A. Y. F., & Wong, Y. H. (2004) · Neuroreport · doi:10.1097/01.wnr.0000130433.90962.6e · Cited by 27

c-Fes tyrosine kinase binds to and activates STAT3 after granulocyte–macrophage colony-stimulating factor stimulation

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The TWEAK Receptor Fn14 Is an Src-Inducible Protein and a Positive Regulator of Src-Driven Cell Invasion

Cheng, E., Whitsett, T. G., Tran, N. L., & Winkles, J. A. (2014) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-14-0411 · Cited by 30

Selective coupling of STAT factors to the mouse prolactin receptor

Mayr, S., Welte, T., Windegger, M., Lechner, J., May, P., Heinrich, P. C., Horn, F., & Doppler, W. (1998) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.1998.2580784.x · Cited by 25

Critical analysis of the potential for targeting STAT3 in human malignancy

Grandis, J., & Peyser (2013) · OncoTargets and Therapy · doi:10.2147/ott.s47903 · Cited by 24

CREPT/RPRD1B promotes tumorigenesis through STAT3-driven gene transcription in a p300-dependent manner

Zhai, W., Ye, X., Wang, Y., Feng, Y., Wang, Y., Lin, Y.-T., Ding, L., Liu, Y., Wang, X., Kuang, Y., et al. (2021) · British Journal of Cancer · doi:10.1038/s41416-021-01269-1 · Cited by 23

Signal Transducers and Activators of Transcription: Novel Targets for Anticancer Therapeutics

Bowman, T. L., Yu, H., Sebti, S. M., Dalton, W. S., & Jove, R. (1999) · Cancer Control · doi:10.1177/107327489900600501 · Cited by 24

Prolactin's role in the early stages of liver regeneration in rats

Olazabal, I. M., Muñoz, J. A., Rodríguez‐Navas, C., Álvarez, L., Delgado‐Baeza, E., & García-Ruiz, J. P. (2009) · Journal of Cellular Physiology · doi:10.1002/jcp.21707 · Cited by 22

NFAT directly regulates Nkx2‐5 transcription during cardiac cell differentiation

Chen, Y., & Cao, X. (2008) · Biology of the Cell · doi:10.1042/bc20080108 · Cited by 23

Src Family Kinase-independent Signal Transduction and Gene Induction by Leukemia Inhibitory Factor

Laszlo, G. S., & Nathanson, N. M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m303670200 · Cited by 24

Dasatinib synergizes with JSI-124 to inhibit growth and migration and induce apoptosis of malignant human glioma cells

Pollack, I. F., Premkumar, D. R., Jane, E. P., Agostino, N. R., & Scialabba, J. L. (2010) · Journal of Carcinogenesis · doi:10.4103/1477-3163.65448 · Cited by 24

Stat3 signaling is present and active during development of the central nervous system and eye of vertebrates

Yan, Y., Bian, W., Xie, Z., Cao, X., Roux, I. L., Guillemot, F., & Jing, N. (2004) · Developmental Dynamics · doi:10.1002/dvdy.20126 · Cited by 24

A Preferential Role for STAT5, not Constitutively Active STAT3, in Promoting Survival of a Human Lymphoid Tumor

Nagy, Z. S., Rui, H., Stepkowski, S. M., Karras, J. G., & Kirken, R. A. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.8.5032 · Cited by 23

Cytokine signaling to the cell cycle

Quelle, F. W. (2007) · Immunologic Research · doi:10.1007/s12026-007-0080-5 · Cited by 20

Sp1 is required for prolactin activation of the interferon regulatory factor-1 gene

McAlexander, M. B., & Yu‐Lee, L. (2001) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(01)00593-7 · Cited by 21

The Inducible Nitric-oxide Synthase (iNOS)/Src Axis Mediates Toll-like Receptor 3 Tyrosine 759 Phosphorylation and Enhances Its Signal Transduction, Leading to Interferon-β Synthesis in Macrophages*

Hsieh, M.-Y., Chang, M., Chen, Y.-J., Li, Y.-K., Chuang, T.-H., Yu, G., Cheung, C., Chen, H.-C., Maa, M., & Leu, T.-H. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.508663 · Cited by 18

Multi-component signaling complexes of the δ-opioid receptor with STAT5B and G proteins

Georganta, E., Agalou, A., & Georgoussi, Z. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2010.04.010 · Cited by 19

ONCOSTATIN M ACTIVATES STAT DNA BINDING AND TRANSCRIPTIONAL ACTIVITY IN PRIMARY HUMAN FETAL ASTROCYTES: LOW- AND HIGH-PASSAGE CELLS HAVE DISTINCT PATTERNS OF STAT ACTIVATION

Schaefer, L. K., Wang, S., & Schaefer, T. S. (2000) · Cytokine · doi:10.1006/cyto.2000.0774 · Cited by 19

Murine Myeloid Dendritic Cells That Phagocytose Apoptotic T Cells Inhibit the Immune Response via NO

Zhong, K., Song, W., Wang, Q., Wang, C., Liu, X., Chen, D., Zhu, Z., Wu, Y., Zhang, W., & Zhang, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0049378 · Cited by 18

v-Src requires Ras signaling for the suppression of gap junctional intercellular communication

Ito, S., Ito, Y., Senga, T., Hattori, S., Matsuo, S., & Hamaguchi, M. (2005) · Oncogene · doi:10.1038/sj.onc.1209263 · Cited by 18

Tissue-microarray based immunohistochemical analysis of survival pathways in nodular sclerosing classical Hodgkin lymphoma as compared with Non-Hodgkin's lymphoma.

De, J., & Brown, R. E. (2010) · PubMed Central · Cited by 18

4. Stat Proteins and Cancer

Bowman, T. L., & Jove, R. (1999) · Cancer Control · doi:10.1177/107327489900600617 · Cited by 18

Matrix-independent Activation of Phosphatidylinositol 3-Kinase, Stat3, and Cyclin A-associated Cdk2 Is Essential for Anchorage-independent Growth of v-Ros-transformed Chicken Embryo Fibroblasts

Uttamsingh, S., Zong, C. S., & Wang, L. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211522200 · Cited by 17

Production of IL-1 receptor antagonist by hepatocytes is regulated as an acute-phase proteinin vivo

Gabay, C., Gigley, J. P., Sipe, J. D., Arend, W. P., & Fantuzzi, G. (2001) · European Journal of Immunology · doi:10.1002/1521-4141(200102)31:2 · Cited by 61

CD2 mediates activation of the IFN‐γ intronic STAT binding region in mucosal T cells

Gonsky, R., Deem, R. L., Young, H. A., & Targan, S. (2003) · European Journal of Immunology · doi:10.1002/eji.200322875 · Cited by 15

Neuropeptide Y activates phosphorylation of ERK and STAT3 in stromal vascular cells from brown adipose tissue, but fails to affect thermogenic function of brown adipocytes

Shimada, K., Ohno, Y., Okamatsu‐Ogura, Y., Suzuki, M., Kamikawa, A., Terao, A., & Kimura, K. (2012) · Peptides · doi:10.1016/j.peptides.2012.02.012 · Cited by 16

Immunohistochemical Study of STAT3 Expression in Feline Injection-site Fibrosarcomas

Petterino, C., Martano, M., Cascio, P., Cerruti, F., Martini, M., Morello, E. M., Bruno, R., Castagnaro, M., & Buracco, P. (2006) · Journal of Comparative Pathology · doi:10.1016/j.jcpa.2005.07.005 · Cited by 14

S ignal T ransducers and A ctivators of T ranscription: I nsights into the M olecular B asis of O ral C ancer

Siavash, H., Nikitakis, N. G., & Sauk, J. J. (2004) · Critical Reviews in Oral Biology & Medicine · doi:10.1177/154411130401500505 · Cited by 14

Approaching non-canonical STAT3 signaling to redefine cancer therapeutic strategy

Dimri, S., Sukanya, S., & De, A. (2017) · Integrative Molecular Medicine · doi:10.15761/imm.1000268 · Cited by 12

Transforming variant of Met receptor confers serum independence and anti-apoptotic property and could be involved in the mouse thymic lymphomagenesis

Baek, C.-M., Jeon, S.-H., Jang, J., Lee, B.-S., & Lee, J. (2004) · Experimental & Molecular Medicine · doi:10.1038/emm.2004.39 · Cited by 13

Identification of genes linked to gefitinib treatment in prostate cancer cell lines with or without resistance to androgen: A clue to application of gefitinib to hormone-resistant prostate cancer

Yano, S., Matsuyama, H., Hirata, H., Inoue, R., Matsumoto, H., Ohmi, C., Miura, K., Shirai, M., Iizuka, N., & Naito, K. (2006) · Oncology Reports · doi:10.3892/or.15.6.1453 · Cited by 13

Targeted approach to metastatic colorectal cancer: what comes beyond epidermal growth factor receptor antibodies and bevacizumab?

Troiani, T., Martinelli, E., Morgillo, F., Capasso, A., Nappi, A. G., Sforza, V., & Ciardiello, F. (2012) · Therapeutic Advances in Medical Oncology · doi:10.1177/1758834012462462 · Cited by 12

PSM/SH2B1 splice variants: Critical role in src catalytic activation and the resulting STAT3s‐mediated mitogenic response

Zhang, M., Deng, Y., & Riedel, H. (2008) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21606 · Cited by 12

Prolactin-Independent Modulation of the β-Casein Response Element by Erk2 MAP Kinase1MAP–mitogen-activated protein; PRL–Prolactin; IFN–interferons; IL–interleukins; GH–growth hormone; EGF–epidermal growth factor; PDGF–platelet-derived growth factor; EPO–erythropoietin; GM-CSF–granulocyte-macrophage colony stimulating factor; CSF-1–colony-stimulating factor-1; HTLV-I–human T cell lymphotrophic virus I; PLSP–Pro-Leu-Ser-Pro; EGF–epidermal growth factor.1

Gao, J., & Horseman, N. D. (1999) · Cellular Signalling · doi:10.1016/s0898-6568(98)00067-9 · Cited by 12

Methylisoindigo and Its Bromo-Derivatives Are Selective Tyrosine Kinase Inhibitors, Repressing Cellular Stat3 Activity, and Target CD133+ Cancer Stem Cells in PDAC

Tegethoff, J. F., Bischoff, R., Saleh, S., Blagojevic, B., Merz, K., & Cheng, X. (2017) · Molecules · doi:10.3390/molecules22091546 · Cited by 11

A novel non-phosphorylated potential antitumoral peptide inhibits STAT3 biological activity☆

Dourlat, J., Liu, W., Sancier, F., Edmonds, T., Pamonsinlapatham, P., Cruzalegui, F. H., & Garbay, C. (2009) · Biochimie · doi:10.1016/j.biochi.2009.05.006 · Cited by 11

Synthesis and evaluation of conformationally constrained peptide analogues as the Src SH3 domain binding ligands

Tiwari, R. K., Brown, A., Narramaneni, S., Sun, G., & Parang, K. (2010) · Biochimie · doi:10.1016/j.biochi.2010.01.017 · Cited by 11

STAT3 Activation, Chemokine Receptor Expression, and Cyclin-Cdk Function in B-1 Cells

Rothstein, T. L., Fischer, G. M., Tanguay, D. A., Pavlovic, S., Colarusso, T. P., Gerstein, R. M., Clarke, S. H., & Chiles, T. C. (2000) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-57284-5_13 · Cited by 11

Trophoblast cell surface antigen-2 phosphorylation triggered by binding of galectin-3 drives metastasis through down-regulation of E-cadherin

Iwamoto, S., Mori, Y., Yamashita, T., Ojima, K., Akita, K., Togano, S., Kushiyama, S., Yashiro, M., Yatera, Y., Yamaguchi, T., et al. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.104971 · Cited by 10

A STATus report on DC development

Li, H. S., & Watowich, S. S. (2012) · Journal of Leukocyte Biology · doi:10.1189/jlb.0212052 · Cited by 11

SIPAR negatively regulates STAT3 signaling and inhibits progression of melanoma

Ren, F., Su, F., Ning, H., Wang, Y., Geng, Y., Feng, Y., Wang, Y., Zhang, Y., Jin, Z. H., Li, Y., et al. (2013) · Cellular Signalling · doi:10.1016/j.cellsig.2013.07.023 · Cited by 10

Identification of a Membrane-associated Inhibitor(s) of Epidermal Growth Factor-induced Signal Transducer and Activator of Transcription Activation

Iwamoto, Y., Chin, Y. E., Peng, X., & Fu, X.-Y. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.29.18198 · Cited by 10

Syndecan-4 is regulated by IL-1β in β-cells and human islets

Brioudes, E., Ahmed, M. A., Lavallard, V., Berney, T., & Bosco, D. (2020) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2020.110815 · Cited by 9

Evidence for ligand-independent homo-oligomerization of leptin receptor (OB-R) isoforms: A proposed mechanism permitting productive long-form signaling in the presence of excess short-form expression

White, D. W., & Tartaglia, L. A. (1999) · Journal of Cellular Biochemistry · doi:10.1002/(sici)1097-4644(19990501)73:2 · Cited by 68

Transcriptional induction of p69 2′–5′-oligoadenylate synthetase by interferon-α is stimulated by 12-O-tetradecanoyl phorbol-13-acetate through IRF/ISRE binding motifs

Yu, F. H. Z., Wang, Q., & Floyd-Smith, G. (1999) · Gene · doi:10.1016/s0378-1119(99)00284-x · Cited by 9

Activation of Stat3 in v-Src-transformed Fibroblasts Requires Cooperation of Jak1 Kinase Activity

Zhang, Y., Turkson, J., Carter‐Su, C., Smithgall, T. E., Levitzki, A., Kraker, A. J., Krolewski, J. J., Medveczky, P. G., & Jove, R. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002383200 · Cited by 166

c-Src Activates both STAT1 and STAT3 in PDGF-Stimulated NIH3T3 Cells

Cirri, P., Chiarugi, P., Marra, F., Raugei, G., Camici, G., Manao, G., & Ramponi, G. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.7493 · Cited by 67

Activation of Stat3 preassembled with platelet-derived growth factor β receptors requires Src kinase activity

Wang, Y.-Z., Wharton, W., Garcia, R., Kraker, A. J., Jove, R., & Pledger, W. J. (2000) · Oncogene · doi:10.1038/sj.onc.1203548 · Cited by 113

Constitutive Activation of JAK1 in Src-transformed Cells

Campbell, G. S., Yu, C., Jove, R., & Carter‐Su, C. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.5.2591 · Cited by 85

Constitutive activation of Stat3 in fibroblasts transformed by diverse oncoproteins and in breast carcinoma cells. Cell Growth Differ

Garcia, R., Yu, C.-L., Hudnall, A., Catlett, R., Nelson, K. L., Smithgall, T., Fujita, D. J., Ethier, S. P., & Jove, R. (1997)