Cited by 359Cytokine Signaling Pathways and InteractionsProtein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.

Activation and Association of Stat3 with Src in v-Src-Transformed Cell Lines

Open access

Cao, Xinmin, Tay, Agnes, Guy, Graeme R., Tan, Y. H.·1996·Molecular and Cellular Biology

DOI 10.1128/mcb.16.4.1595PMC PMC231145

Open this paper in CoChat — free account

Abstract

STAT proteins are a group of latent cytoplasmic transcription factors which function as signal transducers and activators of transcription. Stat1 and -2 were originally identified to function in interferon signaling, and Stat1 was also found to be activated by epidermal growth factor (EGF) and other cytokines. New members of the STAT gene family are identified. Among them, Stat3 has 52.5% amino acid sequence homology with Stat1 and is activated by platelet-derived growth factor (PDGF), colony-stimulating factor 1 (CSF-1), EGF, interleukin-6, and other cytokines. Treatment of cells with EGF activates Stat1 and Stat3, which become phosphorylated on tyrosine residues to form homo - or heterodimers and translocate into the nucleus, binding to the sis-inducible element (SIE) in the c-fos promoter. Somatic cell genetic analyses demonstrated that Jaks, a family of nontransmembrane protein tyrosine kinases, are required for the activation of Stat1 and Stat2 in interferon-treated cells. However, little is known about the activation of Stat3 by growth factors. Here we report that in all v-Src-transformed cell lines examined, Stat3 is constitutively activated to bind to DNA and the phosphorylation of tyrosine on Stat3 is enhanced by the induction of v-Src expression. We also report that Src is shown to be associated with Stat3 in vivo, as well as in vitro, and phosphorylates Stat3 in vitro. Stat3 is also activated by CSF-1, possibly through CSF-1 receptor-c Src association in NIH 3T3 cells overexpressing CSF-1 receptors. Together, the data suggest that Src is involved in activation of Stat3 in growth factor signal transduction.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1128/mcb.16.4.1595

Cites

48 of 48 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei
Dignam, J. D., Lebovitz, R. M., & Roeder, R. G. (1983) · Nucleic Acids Research · doi:10.1093/nar/11.5.1475 · Cited by 11,262
Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins
Darnell, J. E., Kerr, L. M., & Stark, G. R. (1994) · Science · doi:10.1126/science.8197455 · Cited by 6,080
The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains
Hanks, S. K., Quinn, A. M., & Hunter, T. R. (1988) · Science · doi:10.1126/science.3291115 · Cited by 5,040
JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain
Dérijard, B., Hibi, M., Wu, I.-H., Barrett, T., Su, B., Deng, T., Karin, M., & Davis, R. J. (1994) · Cell · doi:10.1016/0092-8674(94)90380-8 · Cited by 3,188
Oncogenes and signal transduction
Cantley, L. C., Auger, K. R., Carpenter, C. F., Duckworth, B. C., Graziani, A., Kapeller, R., & Soltoff, S. P. (1991) · Cell · doi:10.1016/0092-8674(91)90639-g · Cited by 2,697
The stress-activated protein kinase subfamily of c-Jun kinases
Kyriakis, J. M., Banerjee, P. T., Nikolakaki, E., Dai, T., Rubie, E. A., Ahmad, M. F., Avruch, J., & Woodgett, J. R. (1994) · Nature · doi:10.1038/369156a0 · Cited by 2,601
Stat3: a STAT Family Member Activated by Tyrosine Phosphorylation in Response to Epidermal Growth Factor and Interleukin-6
Zhong, Z., Wen, Z., & Darnell, J. E. (1994) · Science · doi:10.1126/science.8140422 · Cited by 2,070
Maximal activation of transcription by statl and stat3 requires both tyrosine and serine phosphorylation
Wen, Z., Zhong, Z., & Darnell, J. E. (1995) · Cell · doi:10.1016/0092-8674(95)90311-9 · Cited by 1,974
Eukaryotic proteins expressed in Escherichia coli: an improved thrombin cleavage and purification procedure of fusion proteins with glutathione S-transferase.
Guan, K., & Dixon, J. (1991) · Analytical Biochemistry · doi:10.1016/0003-2697(91)90534-z · Cited by 1,735
[11] Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin-layer cellulose plates
Boyle, W. J., van der Geer, P., & Hunter, T. R. (1991) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(91)01013-r · Cited by 1,421

Flagged first, then by citations

Show all 48 references

Research works printed but not linked: 4

10.1128/MCB.13.3.1464 · DOI
Muthuswamy S. K., 1995, Oncogene, 11, 1801
ven der Geer P., 1991, Mol. Cell. Biol., 11, 4698
Vignais, M. L., H. B. Sadowski, and M. Z. Gilman. 1995. Activation of STAT proteins by growth factors, A1-368, p. 64. In Abstracts Supplement 19A of the Journal of Cellular Biochemistry 24th Annual Keystone Symposia.

Sorted by citations

STATs: transcriptional control and biological impact
Levy, D. E., & Darnell, J. E. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm909 · Cited by 3,201
CELLULAR FUNCTIONS REGULATED BY SRC FAMILY KINASES
Thomas, S. Μ., & Brugge, J. S. (1997) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.13.1.513 · Cited by 2,537
STATs in oncogenesis
Bowman, T., Garcia, R., Turkson, J., & Jove, R. (2000) · Oncogene · doi:10.1038/sj.onc.1203527 · Cited by 1,743
Constitutive Activation of Stat3 Signaling Confers Resistance to Apoptosis in Human U266 Myeloma Cells
Catlett-Falcone, R., Landowski, T. H., Oshiro, M. M., Turkson, J., Levitzki, A., Savino, R., Ciliberto, G., Moscinski, L., Fernández-Luna, J. L., Nuñez, G., et al. (1999) · Immunity · doi:10.1016/s1074-7613(00)80011-4 · Cited by 1,638
Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3.Preprint
Niwa, H., Burdon, T., Chambers, I., & Smith, A. G. (1998) · Genes & Development · doi:10.1101/gad.12.13.2048 · Cited by 1,673
Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention.
Buettner, R., Mora, L. B., & Jove, R. (2002) · PubMed · Cited by 1,036
Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells
Garcia, R., Bowman, T. L., Niu, G., Yu, H., Minton, S., Muro‐Cacho, C., Cox, C. E., Falcone, R., Fairclough, R., Parsons, S. J., et al. (2001) · Oncogene · doi:10.1038/sj.onc.1204349 · Cited by 756
Src in cancer: deregulation and consequences for cell behaviour
Frame, M. C. (2002) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/s0304-419x(02)00040-9 · Cited by 696
Signal Transducer and Activator of Transcription‐3, Inflammation, and Cancer
Aggarwal, B. B., Kunnumakkara, A. B., Harikumar, K. B., Gupta, S. R., Tharakan, S. T., Koca, C., Dey, S., & Sung, B. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.04911.x · Cited by 663
Stat3 Activation by Src Induces Specific Gene Regulation and Is Required for Cell Transformation
Turkson, J., Bowman, T., Garcia, R., Caldenhoven, E., De Groot, R. P., & Jove, R. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.5.2545 · Cited by 651
STAT proteins: novel molecular targets for cancer drug discovery
Turkson, J., & Jove, R. (2000) · Oncogene · doi:10.1038/sj.onc.1204086 · Cited by 643
Stat3 Activation Is Required for Cellular Transformation by v- src
Bromberg, J. F., Horvath, C. M., Besser, D., Lathem, W. W., & Darnell, J. E. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.5.2553 · Cited by 614
Constitutive activation of Stat3 in human prostate tumors and cell lines: direct inhibition of Stat3 signaling induces apoptosis of prostate cancer cells.
Mora, L. B., Buettner, R., Seigne, J. D., Diaz, J. I., Ahmad, N., Garcia, R., Bowman, T. L., Falcone, R., Fairclough, R., Cantor, A. B., et al. (2002) · PubMed · Cited by 532
Interleukin-6: Biology, signaling and strategies of blockade
Schaper, F., & Rose‐John, S. (2015) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2015.07.004 · Cited by 532
Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor- mediated cell growth In vitro.
Grandis, J. R., Drenning, S. D., Chakraborty, A., Zhou, M. Y., Zeng, Q., Pitt, A. S., & Tweardy, D. J. (1998) · Journal of Clinical Investigation · doi:10.1172/jci3785 · Cited by 507
Janus kinases: components of multiple signaling pathways
Rane, S. G., & Reddy, E. P. (2000) · Oncogene · doi:10.1038/sj.onc.1203925 · Cited by 477
STAT3 Plays a Critical Role in KRAS -Induced Pancreatic Tumorigenesis
Corcoran, R. B., Contino, G., Deshpande, V., Tzatsos, A., Conrad, C., Benes, C. H., Levy, D. E., Settleman, J., Engelman, J. A., & Bardeesy, N. (2011) · Cancer Research · doi:10.1158/0008-5472.can-11-0908 · Cited by 413
“Other tyrosine kinases, such as src, have also been reported to mediate tyrosine phosphorylation of STAT proteins (12).”
Identification and Characterization of a Constitutively Active STAT5 Mutant That Promotes Cell Proliferation
Onishi, M., Nosaka, T., Misawa, K., Mui, A., Gorman, D. M., McMahon, M., Miyajima, A., & Kitamura, T. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.7.3871 · Cited by 411
Novel roles of unphosphorylated STAT3 in oncogenesis and transcriptional regulation
Yang, J., Chatterjee-Kishore, M., Staugaitis, S. M., Nguyen, H., Schlessinger, K., Levy, D. E., & Stark, G. R. (2005) · Cancer Research · doi:10.1158/0008-5472.939.65.3 · Cited by 405
Role of STATs as downstream signal transducers in Src family kinase-mediated tumorigenesis
Silva, C. M. (2004) · Oncogene · doi:10.1038/sj.onc.1208159 · Cited by 412
STAT3 Is Required for the gp130-mediated Full Activation of the c-myc Gene
Kiuchi, N., Nakajima, K., Ichiba, M., Fukada, T., Narimatsu, M., Mizuno, K., Hibi, M., & Hirano, T. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.1.63 · Cited by 401
Jaks, STATs, Cytokine Signal Transduction, and Immunoregulation: Are We There Yet?
O’Shea, J. J. (1997) · Immunity · doi:10.1016/s1074-7613(00)80505-1 · Cited by 377
HIF-1α, STAT3, CBP/p300 and Ref-1/APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas
Gray, M. J., Zhang, J., Ellis, L. M., Semenza, G. L., Evans, D. B., Watowich, S. S., & Gallick, G. E. (2005) · Oncogene · doi:10.1038/sj.onc.1208513 · Cited by 378
Constitutive activation of Stat3 in fibroblasts transformed by diverse oncoproteins and in breast carcinoma cells.
Garcia, R., Yu, C., Hudnall, A. M., Catlett, R., Nelson, K. L., Smithgall, T. E., Fujita, D. J., Ethier, S. P., & Jove, R. (1997) · PubMed · Cited by 369
ErbB Receptor-induced Activation of Stat Transcription Factors Is Mediated by Src Tyrosine Kinases
Olayioye, M. A., Beuvink, I., Horsch, K., Daly, J. M., & Hynes, N. E. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.24.17209 · Cited by 373
JAK/STAT pathway: Extracellular signals, diseases, immunity, and therapeutic regimens
Hu, Q., Bian, Q., Rong, D., Wang, L., Song, J., Huang, H.-S., Zeng, J., Mei, J., & Wang, P. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1110765 · Cited by 387
Functional Roles of STAT Family Proteins: Lessons from Knockout Mice
Akira, S. (1999) · Stem Cells · doi:10.1002/stem.170138 · Cited by 350
Signal transducer and activator of transcription proteins in leukemias
Beneklı, M., Baer, M. R., Baumann, H., & Wetzler, M. (2003) · Blood · doi:10.1182/blood-2002-04-1204 · Cited by 336
The Multifaced Role of STAT3 in Cancer and Its Implication for Anticancer Therapy
Tolomeo, M., & Cascio, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020603 · Cited by 329
The Jak-Stat pathway in normal and perturbed hematopoiesis
Ward, A. C., Touw, I. P., & Yoshimura, A. (2000) · Blood · doi:10.1182/blood.v95.1.19.001k34_19_29 · Cited by 320
Gene therapy with dominant-negative Stat3 suppresses growth of the murine melanoma B16 tumor in vivo.
Niu, G., Heller, R. F., Catlett-Falcone, R., Coppola, D., Jaroszeski, M. J., Dalton, W. S., Jove, R., & Yu, H. (1999) · PubMed · Cited by 313
STAT family of transcription factors in cytokine-mediated biological responses
Takeda, K., & Akira, S. (2000) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(00)00005-8 · Cited by 309
STAT3 Contributes to the Mitogenic Response of Hepatocytes during Liver Regeneration
Li, W., Liang, X., Kellendonk, C., Poli, V., & Taub, R. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202807200 · Cited by 307
Role of the IL-6-JAK1-STAT3-Oct-4 pathway in the conversion of non-stem cancer cells into cancer stem-like cells
Kim, S. Y., Kang, J. W., Song, X., Kim, B. K., Yoo, Y. D., Kwon, Y. T., & Lee, Y. J. (2013) · Cellular Signalling · doi:10.1016/j.cellsig.2013.01.007 · Cited by 306
Induction of p21WAF1/CIP1 and cyclin D1 expression by the Src oncoprotein in mouse fibroblasts: role of activated STAT3 signaling
Sinibaldi, D., Wharton, W., Turkson, J., Bowman, T. L., Pledger, W. J., & Jove, R. (2000) · Oncogene · doi:10.1038/sj.onc.1203947 · Cited by 290
Twist Is Transcriptionally Induced by Activation of STAT3 and Mediates STAT3 Oncogenic Function
Cheng, G. Z., Zhang, W., Sun, M., Wang, Q., Coppola, D., Mansour, M., Xu, L., Costanzo, C. M., Cheng, J. Q., & Wang, L. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m707429200 · Cited by 287
The Structure, Regulation and Function of the Janus Kinases (JAKs) and the Signal Transducers and Activators of Transcription (STATs)
Pellegrini, S., & Dusanter‐Fourt, I. (1997) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1997.00615.x · Cited by 285
Potential role of signal transducer and activator of transcription (STAT)3 signaling pathway in inflammation, survival, proliferation and invasion of hepatocellular carcinoma
Subramaniam, A., Shanmugam, M. K., Perumal, E., Li, F., Nachiyappan, A., Dai, X., Swamy, S. N., Ahn, K. S., Kumar, A. P., Tan, B. K. H., et al. (2012) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2012.10.002 · Cited by 284
Stat3 regulates microtubules by antagonizing the depolymerization activity of stathmin
Ng, D. C. H., Li-n, B., Lim, C. P., Huang, G., Zhang, T., Poli, V., & Cao, X. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200503021 · Cited by 281
Self-citation
Transformation and Stat activation by derivatives of FGFR1, FGFR3, and FGFR4
Hart, K. C., Robertson, S. C., Kanemitsu, M. Y., Meyer, A. N., Tynan, J., & Donoghue, D. (2000) · Oncogene · doi:10.1038/sj.onc.1203650 · Cited by 287
Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity
Sun, J., Blaskovich, M. A., Jove, R., Livingston, S. K., Coppola, D., & Sebti, S. M. (2005) · Oncogene · doi:10.1038/sj.onc.1208470 · Cited by 268
Requirement for Ras/Rac1-Mediated p38 and c-Jun N-Terminal Kinase Signaling in Stat3 Transcriptional Activity Induced by the Src Oncoprotein
Turkson, J., Bowman, T. L., Adnane, J., Zhang, Y., Djeu, J. Y., Sekharam, M., Frank, D. A., Holzman, L. B., Wu, J., Sebti, S. M., et al. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.11.7519 · Cited by 259
Activated signal transducer and activator of transcription 3 (STAT3) supports the malignant phenotype of human pancreatic cancer
Scholz, A., Heinze, S., Detjen, K. M., Peters, M., Welzel, M., Hauff, P., Schirner, M., Wiedenmann, B., & Rosewicz, S. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)01064-3 · Cited by 255
Hematopoietic cytokine receptor signaling
Baker, S. J., Rane, S. G., & Reddy, E. P. (2007) · Oncogene · doi:10.1038/sj.onc.1210757 · Cited by 256
JAKs, STATs and Src kinases in hematopoiesis
Rane, S. G., & Reddy, E. P. (2002) · Oncogene · doi:10.1038/sj.onc.1205398 · Cited by 245
Inhibition of pp60c-Src reduces Bcl-XL expression and reverses the transformed phenotype of cells overexpressing EGF and HER-2 receptors
Karni, R., Jove, R., & Levitzki, A. (1999) · Oncogene · doi:10.1038/sj.onc.1202835 · Cited by 242
Inhibition of constitutive STAT3 activity sensitizes resistant non-Hodgkin's lymphoma and multiple myeloma to chemotherapeutic drug-mediated apoptosis.
Alas, S., & Bonavida, B. (2003) · PubMed · Cited by 239
JAK/STAT Pathways in Cytokine Signaling and Myeloproliferative Disorders: Approaches for Targeted Therapies
Jatiani, S., Baker, S. J., Silverman, L. R., & Reddy, E. P. (2010) · Genes & Cancer · doi:10.1177/1947601910397187 · Cited by 228
Leukemia Inhibitory Factor–dependent Transcriptional Activation in Embryonic Stem Cells
Bœuf, H., Hauss, C., Graeve, F. D., Baran, N., & Kédinger, C. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.138.6.1207 · Cited by 231
The role of STATs in myeloid differentiation and leukemia
Coffer, P. J., Koenderman, L., & de Groot, R. P. (2000) · Oncogene · doi:10.1038/sj.onc.1203479 · Cited by 225
Serine Phosphorylation and Negative Regulation of Stat3 by JNK
Lim, C. P., & Cao, X. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.43.31055 · Cited by 225
Self-citation
Signaling network of the Btk family kinases
Qiu, Y., & Kung, H.-J. (2000) · Oncogene · doi:10.1038/sj.onc.1203958 · Cited by 225
STAT3 in the systemic inflammation of cancer cachexia
Zimmers, T. A., Fishel, M. L., & Bonetto, A. (2016) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2016.02.009 · Cited by 231
IL-3 signaling and the role of Src kinases, JAKs and STATs: a covert liaison unveiled
Reddy, E. P., Korapati, A. L., Chaturvedi, P., & Rane, S. G. (2000) · Oncogene · doi:10.1038/sj.onc.1203594 · Cited by 224
GRIM‐19, a death‐regulatory gene product, suppresses Stat3 activity via functional interaction
Lufei, C., Ma, J., Huang, G., Zhang, T., Novotny‐Diermayr, V., Ong, C. T., & Cao, X. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg135 · Cited by 220
Self-citation
The c‐myc Promoter: Still MysterY and Challenge
(2008) · Advances in Cancer Research · doi:10.1016/s0065-230x(07)99004-1 · Cited by 211
Activation of STAT Transcription Factors in Oncogenic Tyrosine Kinase Signaling
Garcia, R., & Jove, R. (1998) · Journal of Biomedical Science · doi:10.1007/bf02258360 · Cited by 206
Protein Kinase C δ Associates with and Phosphorylates Stat3 in an Interleukin-6-dependent Manner
Jain, N. K., Zhang, T., Kee, W. H., Li, W., & Cao, X. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.34.24392 · Cited by 206
Self-citation
Constitutive Stat3, Tyr705, and Ser727 phosphorylation in acute myeloid leukemia cells caused by the autocrine secretion of interleukin-6.
Schuringa, J., Wierenga, A., Kruijer, W., & Vellenga, E. (2000) · Blood · doi:10.1182/blood.v95.12.3765 · Cited by 213
The STAT3 pathway as a therapeutic target in head and neck cancer: barriers and innovations
Geiger, J. L., Grandis, J. R., & Bauman, J. E. (2016) · Oral Oncology · doi:10.1016/j.oraloncology.2015.11.022 · Cited by 193
Signaling Mechanisms Regulating Self-Renewal and Differentiation of Pluripotent Embryonic Stem Cells
Burdon, T., Chambers, I., Stracey, C., Niwa, H., & Smith, A. G. (1999) · Cells Tissues Organs · doi:10.1159/000016693 · Cited by 200
STAT 3 the oncogene – still eluding therapy?
Wake, M., & Watson, C. J. (2015) · FEBS Journal · doi:10.1111/febs.13285 · Cited by 188
Multiple tyrosine residues in the cytosolic domain of the erythropoietin receptor promote activation of STAT5.
Klingmüller, U., Bergelson, S., Hsiao, J. G., & Lodish, H. F. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.16.8324 · Cited by 189
STAT5 Activation by BCR-Abl Contributes to Transformation of K562 Leukemia Cells
de Groot, R. P., Raaijmakers, J. A. M., Lammers, J. J., Jove, R., & Koenderman, L. (1999) · Blood · doi:10.1182/blood.v94.3.1108.415k07_1108_1112 · Cited by 188
Conditional gene ablation of Stat3 reveals differential signaling requirements for survival of motoneurons during development and after nerve injury in the adult
Schweizer, U., Gunnersen, J. M., Karch, C., Wiese, S., Holtmann, B., Takeda, K., Akira, S., & Sendtner, M. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200107009 · Cited by 186
STAT proteins as novel targets for cancer therapy
Catlett-Falcone, R., Dalton, W. S., & Jove, R. (1999) · Current Opinion in Oncology · doi:10.1097/00001622-199911000-00010 · Cited by 185
Src Kinases Mediate STAT Growth Pathways in Squamous Cell Carcinoma of the Head and Neck
Xi, S., Zhang, Q. H., Dyer, K. F., Lerner, E. C., Smithgall, T. E., Gooding, W. E., Kamens, J., & Grandis, J. R. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m303499200 · Cited by 181
Activation of STAT3 by the Src Family Kinase Hck Requires a Functional SH3 Domain
Schreiner, S. J., Schiavone, A. P., & Smithgall, T. E. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204255200 · Cited by 176
The Jak/Stat Pathway and Urokinase Receptor Signaling in Human Aortic Vascular Smooth Muscle Cells
Dumler, I., Weis, A., Mayboroda, O. A., Maasch, C., Jerke, U., Haller, H. G., & Gulba, D. C. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.1.315 · Cited by 176
Autoregulation of the Stat3 Gene through Cooperation with a cAMP-responsive Element-binding Protein
Ichiba, M., Nakajima, K., Yamanaka, Y., Kiuchi, N., & Hirano, T. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.11.6132 · Cited by 175
Lyn Physically Associates With the Erythropoietin Receptor and May Play a Role in Activation of the Stat5 Pathway
Chin, H., Arai, A., Wakao, H., Kamiyama, R., Miyasaka, N., & Miura, O. (1998) · Blood · doi:10.1182/blood.v91.10.3734 · Cited by 175
Signal Transducers and Activators of Transcription (STATs): Novel Targets of Chemopreventive and Chemotherapeutic Drugs
Klampfer, L. (2006) · Current Cancer Drug Targets · doi:10.2174/156800906776056491 · Cited by 169
Constitutive activation of Stat3α in brain tumors: localization to tumor endothelial cells and activation by the endothelial tyrosine kinase receptor (VEGFR-2)
Schaefer, L. K., Ren, Z., Fuller, G. N., & Schaefer, T. S. (2002) · Oncogene · doi:10.1038/sj.onc.1205263 · Cited by 175
Activation of Stat3 in v-Src-transformed Fibroblasts Requires Cooperation of Jak1 Kinase Activity
Zhang, Y., Turkson, J., Carter‐Su, C., Smithgall, T. E., Levitzki, A., Kraker, A. J., Krolewski, J. J., Medveczky, P. G., & Jove, R. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002383200 · Cited by 166
A Functional Nuclear Epidermal Growth Factor Receptor, Src and Stat3 Heteromeric Complex in Pancreatic Cancer Cells
Jaganathan, S., Yue, P., Paladino, D., Bogdanović, J. M., Huo, Q., & Turkson, J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019605 · Cited by 172
Retracted
Leptin and IL-6 Family Cytokines Synergize to Stimulate Müller Glia Reprogramming and Retina Regeneration
Zhao, X., Wan, J., Powell, C., Ramachandran, R., Myers, M. G., & Goldman, D. J. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.08.047 · Cited by 154
Targeting Stat3 Abrogates EGFR Inhibitor Resistance in Cancer
Sen, M., Joyce, S., Panahandeh, M., Li, C., Thomas, S. M., Maxwell, J., Wang, L., Gooding, W. E., Johnson, D. E., & Grandis, J. R. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-0792 · Cited by 158
The function of Stat3 in tumor cells and their microenvironment
Groner, B., Lucks, P., & Borghouts, C. (2008) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2008.06.005 · Cited by 160
Cyclooxygenase-2 in tumorigenesis of gastrointestinal cancers: An update on the molecular mechanisms
Wu, W. K. K., Sung, J. J. �., Lee, C. W., Yu, J. Q., & Cho, C. H. (2010) · Cancer Letters · doi:10.1016/j.canlet.2010.03.015 · Cited by 153
Functional Interaction of STAT3 Transcription Factor with the Coactivator NcoA/SRC1a
Giraud, S., Bienvenu, F., Avril, S., Gascan, H., Heery, D. M., & Coqueret, O. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111486200 · Cited by 149
The coiled-coil domain of Stat3 is essential for its SH2 domain-mediated receptor binding and subsequent activation induced by epidermal growth factor and interleukin-6
Zhang, T., Kee, W. H., Seow, K. T., Fung, W., & Cao, X. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.19.7132-7139.2000 · Cited by 150
Self-citation
Signal Transducer and Activator of Transcription-3 (STAT3) Is Constitutively Activated in Normal, Self-renewing B-1 Cells but Only Inducibly Expressed in Conventional B Lymphocytes
Karras, J., Wang, Z.-H., Huo, L., Howard, R., Frank, D., & Rothstein, T. (1997) · Journal of Experimental Medicine · doi:10.1084/jem.185.6.1035 · Cited by 160
STATs as critical mediators of signal transduction and transcription: lessons learned from STAT5
Paukku, K., & Silvennoinen, O. (2004) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2004.09.001 · Cited by 147
Reactive Oxygen Species as Mediators of Signal Transduction in Ischemic Preconditioning
Otani, H. (2004) · Antioxidants and Redox Signaling · doi:10.1089/152308604322899521 · Cited by 139
Etk, a Btk Family Tyrosine Kinase, Mediates Cellular Transformation by Linking Src to STAT3 Activation
Tsai, Y.-T., Su, Y., Fang, S.-S., Huang, T.-N., Qiu, Y., Jou, Y., Shih, H.-M., Kung, H.-J., & Chen, R. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.6.2043-2054.2000 · Cited by 141
STAT5-Dependent CyclinD1 and Bcl-xL Expression in Bcr-Abl-Transformed Cells
de Groot, R. P., Raaijmakers, J. A. M., Lammers, J. J., & Koenderman, L. (2000) · Molecular Cell Biology Research Communications · doi:10.1006/mcbr.2000.0231 · Cited by 140
Sustained Receptor Activation and Hyperproliferation in Response to Granulocyte Colony-stimulating Factor (G-CSF) in Mice with a Severe Congenital Neutropenia/Acute Myeloid Leukemia–derived Mutation in the G-CSF Receptor Gene
Hermans, M. H. A., Antonissen, C., Ward, A. C., Mayen, A. E. M., Ploemacher, R., & Touw, I. P. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.4.683 · Cited by 139
Serine phosphorylation of STAT3 is essential for Mcl-1 expression and macrophage survival
Liu, H., Ma, Y., Cole, S. M., Zander, C., Chen, K.-H., Karras, J., & Pope, R. M. (2003) · Blood · doi:10.1182/blood-2002-11-3396 · Cited by 140
VEGF, VEGFRs expressions and activated STATs in ovarian epithelial carcinoma
Chen, H., Ye, D.-F., Xie, X., Chen, B., & Lü, W. (2004) · Gynecologic Oncology · doi:10.1016/j.ygyno.2004.05.056 · Cited by 133
Control of myeloid differentiation and survival by Stats
Smithgall, T. E., Briggs, S. D., Schreiner, S. J., Lerner, E. C., Cheng, H. Y., & Wilson, M. B. (2000) · Oncogene · doi:10.1038/sj.onc.1203477 · Cited by 134
G protein coupled receptor signaling through the Src and Stat3 pathway: role in proliferation and transformation
Ram, P. T., & Iyengar, R. (2001) · Oncogene · doi:10.1038/sj.onc.1204186 · Cited by 132
Combined STAT3 and BCR-ABL1 inhibition induces synthetic lethality in therapy-resistant chronic myeloid leukemia
Eiring, A. M., Page, B. D. G., Kraft, I. L., Mason, C. C., Vellore, N. A., Resetca, D., Zabriskie, M. S., Zhang, T. Y., Khorashad, J. S., Engar, A., et al. (2014) · Leukemia · doi:10.1038/leu.2014.245 · Cited by 140
Defective Internalization and Sustained Activation of Truncated Granulocyte Colony-Stimulating Factor Receptor Found in Severe Congenital Neutropenia/Acute Myeloid Leukemia
Ward, A. C., van Aesch, Y. M., Schelen, A. M., & Touw, I. P. (1999) · Blood · doi:10.1182/blood.v93.2.447 · Cited by 131
STAT5 Interaction with the T Cell Receptor Complex and Stimulation of T Cell Proliferation
Welte, T., Leitenberg, D., Dittel, B. N., al-Ramadi, B. K., Xie, B., Chin, Y. E., Janeway, C. A., Bothwell, A. L. M., Bottomly, K., & Fu, X.-Y. (1999) · Science · doi:10.1126/science.283.5399.222 · Cited by 130
An essential role for SRC-activated STAT-3 in 14,15-EET–induced VEGF expression and angiogenesis
Cheranov, S. Y., Karpurapu, M., Wang, D., Zhang, B., Venema, R. C., & Rao, G. N. (2008) · Blood · doi:10.1182/blood-2007-11-126680 · Cited by 131
PI3K and STAT3: A New Alliance
Vogt, P. K., & Hart, J. R. (2011) · Cancer Discovery · doi:10.1158/2159-8290.cd-11-0218 · Cited by 131
Identification of Both Positive and Negative Domains within the Epidermal Growth Factor Receptor COOH-terminal Region for Signal Transducer and Activator of Transcription (STAT) Activation
Xia, L., Wang, L., Chung, A. S., Ivanov, S. S., Ling, M. Y., Dragoi, A. M., Platt, A., Gilmer, T. M., Fu, X.-Y., & Chin, Y. E. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202823200 · Cited by 126
A Single Amino Acid Substitution in the v-Eyk Intracellular Domain Results in Activation of Stat3 and Enhances Cellular Transformation
Besser, D., Bromberg, J., Darnell, J. E., Jr., & Hanafusa, H. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.2.1401 · Cited by 123
Regulation of Stat3 nuclear import by importin α5 and importin α7 via two different functional sequence elements
Ma, J., & Cao, X. (2005) · Cellular Signalling · doi:10.1016/j.cellsig.2005.06.016 · Cited by 121
Self-citation
STAT Signaling in the Pathogenesis and Treatment of Cancer
Frank, D. A. (1999) · Molecular Medicine · doi:10.1007/bf03403538 · Cited by 118

Authors: Cao, X., Tay, A., Guy, G. R., & Tan, Y. H.
Affiliations: National University of Singapore (SG)
ORCID: Tan, Y. H.
Venue: Molecular and Cellular Biology
Publisher: Informa UK Limited
Published: 1996-04-01
Volume: 16
Issue: 4
Pages: 1595-1603
ISSN: 0270-7306 (ISSN-L)
1098-5549
DOI: 10.1128/mcb.16.4.1595
PMC: PMC231145
OpenAlex: W2135055828
Cited by: 359
References: 48
Citations by year: 2026: 1 · 2025: 2 · 2024: 2 · 2023: 4 · 2021: 6 · 2020: 4 · 2019: 2 · 2018: 4 · 2017: 5 · 2016: 7 · 2015: 8 · 2014: 13 · 2013: 7 · 2012: 14
FWCI: 13.79
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Molecular and Cellular Biology (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
National University of Singapore (submittedVersion)
Funders: National Science Board
Topics: Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
Keywords: STAT3, Src kinase, v-Src, tyrosine phosphorylation, STAT3 activation, protein-protein interaction, CSF-1 receptor, colony-stimulating factor 1, growth factor signaling, JAK kinases, interferon signaling, STAT1, STAT2, transcription factor dimerization, 3T3 fibroblasts
MeSH terms: Animals, Cell Line, Transformed, DNA-Binding Proteins, Enzyme Activation, Epidermal Growth Factor, Phosphorylation, Platelet-Derived Growth Factor, Trans-Activators, Gene Expression, Macrophage Colony-Stimulating Factor, Receptors, Colony-Stimulating Factor, Genes, src, 3T3 Cells, src-Family Kinases, STAT3 Transcription Factor, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Activation and Association of Stat3 with Src in v-Src-Transformed Cell Lines

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks