The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Isolation and Characterization of a Novel Epithelium-Specific Transcription Factor, ESE-1, a Member of the ets Family
Open accessAbstract
We report here the isolation of a novel, highly tissue-restricted member of the ets transcription factor/oncogene family, ESE-1 (for epithelium-specific Ets), which has features distinct from those of any other ets-related factor. ESE-1 contains two putative DNA binding domains: an ETS domain, which is unique in that the 5' half shows relatively weak homology to known ets factors, and an A/T hook domain, found in HMG proteins and various other nuclear factors. In contrast to any known ets factors, ESE-1 is expressed exclusively in epithelial cells. ESE-1 expression is induced during terminal differentiation of the epidermis and in a primary human keratinocyte differentiation system. The keratinocyte terminal differentiation marker gene, SPRR2A, is a putative target for ESE-1, since SPRR2A expression during keratinocyte differentiation correlates with induction of ESE-1 expression, and ESE-1 binds with high affinity to and transactivates the ets binding site in the SPRR2A promoter. ESE-1 also binds to and transactivates the enhancer of the Endo A gene, a potential target for ESE-1 in simple epithelia. Due to the important role that other ets factors play in cellular differentiation, ESE-1 is expected to be a critical regulator of epithelial cell differentiation.
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Cites
Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours
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Klämbt, C. (1993) · Development · doi:10.1242/dev.117.1.163 · Cited by 332
Defective activation and survival of T cells lacking the Ets-1 transcription factor
Muthusamy, N., Barton, K., & Leiden, J. M. (1995) · Nature · doi:10.1038/377639a0 · Cited by 330
A new pattern for helix–turn–helix recognition revealed by the PU.l ETS–domain–DNA complex
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The proto-oncogene PU.1 regulates expression of the myeloid-specific CD11b promoter
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Characterization of Spi-B, a transcription factor related to the putative oncoprotein Spi-1/PU.1.
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Cited by
Molecular biology of the Ets family of transcription factors
Oikawa, T., & Yamada, T. (2003) · Gene · doi:10.1016/s0378-1119(02)01156-3 · Cited by 688
NF-κB Signaling: Multiple Angles to Target OA
B. Marcu, K., Otero, M., Olivotto, E., Maria Borzi, R., & B. Goldring, M. (2010) · Current Drug Targets · doi:10.2174/138945010791011938 · Cited by 565
535 East 70th Street, C. R. B., Goldring, M., Otero, M., Plumb, D., Dragomir, C., Favero, M., EI Hachem, K., Hashimoto, K., Roach, H., Olivotto, E., et al. (2011) · European Cells and Materials · doi:10.22203/ecm.v021a16 · Cited by 489
Ets target genes: past, present and future
Sementchenko, V. I., & Watson, D. K. (2000) · Oncogene · doi:10.1038/sj.onc.1204034 · Cited by 371
Specificity within the ets Family of Transcription Factors
(1998) · Advances in Cancer Research · doi:10.1016/s0065-230x(08)60738-1 · Cited by 344
Metadata
- Authors
- Oettgen, P., Alani, R. M., Barcinski, M. A., Brown, L., Akbarali, Y., Boltax, J., Kunsch, C., Munger, K., & Libermann, T. A.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 1997-08-01
- Volume
- 17
- Issue
- 8
- Pages
- 4419-4433
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W2100688706
- Cited by
- 215
- References
- 7
- FWCI
- 5.68
- Type
- journal article
- Language
- en
- Open access
- green
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- Oettgen, P., Alani, R. M., Barcinski, M. A., Brown, L., Akbarali, Y., Boltax, J., Kunsch, C., Munger, K., & Libermann, T. A. (1997). Isolation and Characterization of a Novel Epithelium-Specific Transcription Factor, ESE-1, a Member of the ets Family. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.17.8.4419
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