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C-Terminal Binding Protein Is a Transcriptional Repressor That Interacts with a Specific Class of Vertebrate Polycomb Proteins
Open accessAbstract
Polycomb (Pc) is part of a Pc group (PcG) protein complex that is involved in repression of gene activity during Drosophila and vertebrate development. To identify proteins that interact with vertebrate Pc homologs, we performed two-hybrid screens with Xenopus Pc (XPc) and human Pc 2 (HPC2). We find that the C-terminal binding protein (CtBP) interacts with XPc and HPC2, that CtBP and HPC2 coimmunoprecipitate, and that CtBP and HPC2 partially colocalize in large PcG domains in interphase nuclei. CtBP is a protein with unknown function that binds to a conserved 6-amino-acid motif in the C terminus of the adenovirus E1A protein. Also, the Drosophila CtBP homolog interacts, through this conserved amino acid motif, with several segmentation proteins that act as repressors. Similarly, we find that CtBP binds with HPC2 and XPc through the conserved 6-amino-acid motif. Importantly, CtBP does not interact with another vertebrate Pc homolog, M33, which lacks this amino acid motif, indicating specificity among vertebrate Pc homologs. Finally, we show that CtBP is a transcriptional repressor. The results are discussed in terms of a model that brings together PcG-mediated repression and repression systems that require corepressors such as CtBP.
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Functions of mammalian Polycomb group and trithorax group related genes.
Gould, A. (1997) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(97)80075-5 · Cited by 198
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Shi, Y., Sawada, J.-I., Sui, G., Affar, E. B., Whetstine, J. R., Lan, F., Ogawa, H., Po-Shan Luke, M., Nakatani, Y., & Shi, Y. (2003) · Nature · doi:10.1038/nature01550 · Cited by 801
Levine, S. S., Weiss, A., Erdjument-Bromage, H., Shao, Z., Tempst, P., & Kingston, R. E. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.17.6070-6078.2002 · Cited by 388
Recent lessons in gene expression, cell cycle control, and cell biology from adenovirus
Berk, A. J. (2005) · Oncogene · doi:10.1038/sj.onc.1209040 · Cited by 377
Shi, B., Liang, J., Yang, X., Wang, Y., Zhao, Y., Wu, H., Sun, L., Zhang, Y., Chen, Y., Li, R., et al. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00162-07 · Cited by 340
Metadata
- Authors
- Sewalt, R. G. A. B., Gunster, M. J., van der Vlag, J., Satijn, D. P. E., & Otte, A. P.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 1999-01-01
- Volume
- 19
- Issue
- 1
- Pages
- 777-787
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W2100885802
- Cited by
- 195
- References
- 1
- FWCI
- 6.74
- Type
- journal article
- Language
- en
- Open access
- green
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- Sewalt, R. G. A. B., Gunster, M. J., van der Vlag, J., Satijn, D. P. E., & Otte, A. P. (1999). C-Terminal Binding Protein Is a Transcriptional Repressor That Interacts with a Specific Class of Vertebrate Polycomb Proteins. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.19.1.777
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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