The DOI matches its Crossref record; 66 of the 66 references it cites were found in a registry or an index.
The Core of the Polycomb Repressive Complex Is Compositionally and Functionally Conserved in Flies and Humans
Open accessAbstract
The Polycomb group (PcG) genes are required to maintain homeotic genes in a silenced state during development in drosophila and mammals and are thought to form several distinct silencing complexes that maintain homeotic gene repression during development. Mutations in the PcG genes result in developmental defects and have been implicated in human cancer. Although some PcG protein domains are conserved between flies and humans, substantial regions of several PcG proteins are divergent and humans contain multiple versions of each PcG gene. To determine the effects of these changes on the composition and function of a PcG complex, we have purified a human Polycomb repressive complex from HeLa cells (hPRC-H) that contains homologues of PcG proteins found in drosophila embryonic PRC1 (dPRC1). hPRC-H was found to have fewer components than dPRC1, retaining the PcG core proteins of dPRC1 but lacking most non-PcG proteins. Preparations of hPRC-H contained either two or three different homologues of most of the core PcG proteins, including a new Ph homologue we have named HPH3. Despite differences in composition, dPRC1 and hPRC-H have similar functions: hPRC-H is able to efficiently block remodeling of nucleosomal arrays through a mechanism that does not block the ability of nucleases to access and cleave the arrays.
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Cites
The Polycomb-Group Gene Ezh2 Is Required for Early Mouse Development
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Stabilization of Chromatin Structure by PRC1, a Polycomb Complex
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Self-citationIdentification of cooperating oncogenes in Eμ-myc transgenic mice by provirus tagging
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Self-citationTHE POLYCOMB AND TRITHORAX GROUP PROTEINS OF DROSOPHILA: Trans-Regulators of Homeotic Gene Function
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Cited by
Role of histone H2A ubiquitination in Polycomb silencing
Wang, H., Wang, L., Erdjument-Bromage, H., Vidal, M., Tempst, P., Jones, R. S., & Zhang, Y. (2004) · Nature · doi:10.1038/nature02985 · Cited by 1,663
Self-citationEpigenetic Regulation of Cellular Memory by the Polycomb and Trithorax Group Proteins
Ringrose, L., & Paro, R. (2004) · Annual Review of Genetics · doi:10.1146/annurev.genet.38.072902.091907 · Cited by 1,077
de Napoles, M., Mermoud, J. E., Wakao, R., Tang, Y. A., Endoh, M., Appanah, R., Nesterova, T. B., Silva, J., Otte, A. P., Vidal, M., et al. (2004) · Developmental Cell · doi:10.1016/j.devcel.2004.10.005 · Cited by 888
Polycomb silencing mechanisms and the management of genomic programmes
Schwartz, Y. B., & Pirrotta, V. (2007) · Nature Reviews Genetics · doi:10.1038/nrg1981 · Cited by 868
Transcriptional regulation by Polycomb group proteins
Di Croce, L., & Helin, K. (2013) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2669 · Cited by 864
Metadata
- Authors
- Levine, S. S., Weiss, A., Erdjument-Bromage, H., Shao, Z., Tempst, P., & Kingston, R. E.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 2002-09-01
- Volume
- 22
- Issue
- 17
- Pages
- 6070-6078
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W2013832080
- Cited by
- 388
- References
- 66
- FWCI
- 5.40
- Type
- journal article
- Language
- en
- Open access
- green
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- Levine, S. S., Weiss, A., Erdjument-Bromage, H., Shao, Z., Tempst, P., & Kingston, R. E. (2002). The Core of the Polycomb Repressive Complex Is Compositionally and Functionally Conserved in Flies and Humans. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.22.17.6070-6078.2002
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