The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Disruption of muREC2/RAD51L1 in Mice Results in Early Embryonic Lethality Which Can Be Partially Rescued in a p53−/− Background
Open accessAbstract
muREC2/RAD51L1 is a radiation-inducible gene that regulates cell cycle progression. To elucidate the biological function of muREC2/RAD51L1, the gene was disrupted in embryonic stem cells by homologous recombination. Mice heterozygous for muREC2/RAD51L1 appear normal and fertile; however, no homozygous pups were born after interbreeding of heterozygous mice. Timed pregnancy studies showed that homozygous mutant embryos were severely retarded in growth as early as ca. 5 days gestation (E5.5) and were completely resorbed by E8.5. Mutant blastocyst outgrowth was also severely impaired in a double-knockout embryo, but embryonic development did progress further in a p53-null background. These results suggest that muREC2/RAD51L1 plays a role in cell proliferation and early embryonic development, perhaps through interaction with p53.
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Citations
Cites
Targeted mutation of the DNA methyltransferase gene results in embryonic lethality
Li, E., Bestor, T. H., & Jaenisch, R. (1992) · Cell · doi:10.1016/0092-8674(92)90611-f · Cited by 3,984
Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53
de Oca Luna, R. M., Wagner, D. S., & Lozano, G. (1995) · Nature · doi:10.1038/378203a0 · Cited by 1,420 · cited 1×
“p53 plays a pivotal role in cell cycle control and apoptosis, and the embryonic lethality caused by mRAD51, BRCA1, and BRCA2 is partially rescued while mdm2-deficient mice are completely rescued in a p53-null background (9, 16, 17, 19).”
Background
Cited by
Homologous Recombination and Human Health: The Roles of BRCA1, BRCA2, and Associated Proteins
Prakash, R., Zhang, Y., Feng, W., & Jasin, M. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a016600 · Cited by 869
The Fanconi anaemia/BRCA pathway
D'Andrea, A. D., & Grompe, M. (2003) · Nature Reviews Cancer · doi:10.1038/nrc970 · Cited by 822
Repair of DNA interstrand cross-links
Dronkert, M. L. G., & Kanaar, R. (2001) · Mutation Research/DNA Repair · doi:10.1016/s0921-8777(01)00092-1 · Cited by 555
Loss of murine TDP-43 disrupts motor function and plays an essential role in embryogenesis
Kraemer, B. C., Schuck, T., Wheeler, J. M., Robinson, L. C., Trojanowski, J. Q., Lee, V. M. Y., & Schellenberg, G. D. (2010) · Acta Neuropathologica · doi:10.1007/s00401-010-0659-0 · Cited by 350
The RAD51 gene family, genetic instability and cancer
Thacker, J. (2005) · Cancer Letters · doi:10.1016/j.canlet.2004.08.018 · Cited by 342
Metadata
- Authors
- Shu, Z., Smith, S., Wang, L., Rice, M. C., & Kmiec, E. B.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 1999-12-01
- Volume
- 19
- Issue
- 12
- Pages
- 8686-8693
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W2099251067
- Cited by
- 174
- References
- 2
- FWCI
- 3.48
- Type
- journal article
- Language
- en
- Open access
- green
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- The paper
- Shu, Z., Smith, S., Wang, L., Rice, M. C., & Kmiec, E. B. (1999). Disruption of muREC2/RAD51L1 in Mice Results in Early Embryonic Lethality Which Can Be Partially Rescued in a p53−/− Background. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.19.12.8686
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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