The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
DNA-mediated transfer of multiple drug resistance and plasma membrane glycoprotein expression.
Open accessAbstract
Colchicine-resistant Chinese hamster ovary (CHO) cell mutants whose resistance results from reduced drug permeability have been isolated previously in our laboratories. This reduced permeability affects a wide range of unrelated drugs, resulting in the mutants displaying a multiple drug resistance phenotype. A 170,000-dalton cell surface glycoprotein (P-glycoprotein) was identified, and its expression appears to correlate with the degree of resistance. In this study we were able to confer the multiple drug resistance phenotype on sensitive mouse L cells by DNA-mediated gene transfer of DNA obtained from the colchicine-resistant mutants. P-glycoprotein was detected in plasma membranes of these DNA transformants by staining with an antiserum raised against membranes of mutant CHO cells. These results are consistent with a causal relationship between P-glycoprotein expression and the multiple drug resistance phenotype.
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Citations
Cites
Burton, K. (1956) · Biochemical Journal · doi:10.1042/bj0620315 · Cited by 14,090
Cited by
Cell Surface P-Glycoprotein Associated with Multidrug Resistance in Mammalian Cell Lines
Kartner, N., Riordan, J. R., & Ling, V. (1983) · Science · doi:10.1126/science.6137059 · Cited by 991
Self-citationThe molecular basis of multidrug resistance in cancer: The early years of P‐glycoprotein research
Gottesman, M. M., & Ling, V. (2006) · FEBS Letters · doi:10.1016/j.febslet.2005.12.060 · Cited by 558
Self-citationHamada, H., & Tsuruo, T. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)57324-0 · Cited by 332
Metadata
- Authors
- Debenham, P. G., Kartner, N., Siminovitch, L., Riordan, J. R., & Ling, V
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 1982-08
- Volume
- 2
- Issue
- 8
- Pages
- 881-889
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W1900543109
- Cited by
- 201
- References
- 1
- FWCI
- 8.02
- Type
- journal article
- Language
- en
- Open access
- green
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- Debenham, P. G., Kartner, N., Siminovitch, L., Riordan, J. R., & Ling, V. (1982). DNA-mediated transfer of multiple drug resistance and plasma membrane glycoprotein expression. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.2.8.881
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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