Cited by 164DNA Repair MechanismsFungal and yeast genetics researchBacterial Genetics and Biotechnology

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DNA Repair Protein Rad55 Is a Terminal Substrate of the DNA Damage Checkpoints

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Bashkirov, Vladimir I., King, Jeff S., Bashkirova, Elena V., Schmuckli-Maurer, Jacqueline, Heyer, Wolf-Dietrich·2000·Molecular and Cellular Biology

DOI 10.1128/mcb.20.12.4393-4404.2000PMC PMC85806

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Abstract

Checkpoints, which are integral to the cellular response to DNA damage, coordinate transient cell cycle arrest and the induced expression of DNA repair genes after genotoxic stress. DNA repair ensures cellular survival and genomic stability, utilizing a multipathway network. Here we report evidence that the two systems, DNA damage checkpoint control and DNA repair, are directly connected by demonstrating that the Rad55 double-strand break repair protein of the recombinational repair pathway is a terminal substrate of DNA damage and replication block checkpoints. Rad55p was specifically phosphorylated in response to DNA damage induced by the alkylating agent methyl methanesulfonate, dependent on an active DNA damage checkpoint. Rad55p modification was also observed after gamma ray and UV radiation. The rapid time course of phosphorylation and the recombination defects identified in checkpoint-deficient cells are consistent with a role of the DNA damage checkpoint in activating recombinational repair. Rad55p phosphorylation possibly affects the balance between different competing DNA repair pathways.

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Authors: Bashkirov, V. I., King, J. S., Bashkirova, E. V., Schmuckli-Maurer, J., & Heyer, W.-D.
Affiliations: Russian Academy of Sciences (RU)
Institute of General Microbiology
University of California, Davis (US)
Corresponding author: Heyer, Wolf-Dietrich
ORCID: Heyer, Wolf-Dietrich
Venue: Molecular and Cellular Biology
Publisher: Informa UK Limited
Published: 2000-06-01
Volume: 20
Issue: 12
Pages: 4393-4404
ISSN: 0270-7306 (ISSN-L)
1098-5549
DOI: 10.1128/mcb.20.12.4393-4404.2000
PMC: PMC85806
OpenAlex: W2121218667
Cited by: 164
References: 98
Citations by year: 2026: 2 · 2025: 2 · 2024: 3 · 2023: 3 · 2022: 1 · 2021: 4 · 2019: 1 · 2018: 3 · 2017: 1 · 2016: 9 · 2015: 1 · 2014: 3 · 2013: 1 · 2012: 7
FWCI: 7.11
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Molecular and Cellular Biology (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Keywords: Rad55, DNA damage checkpoint, DNA repair, phosphorylation, recombinational repair, DNA double-strand break repair, methyl methanesulfonate, gamma radiation, ultraviolet radiation, recombination defects, cell cycle arrest, genome stability
MeSH terms: DNA Damage, DNA Repair, DNA-Binding Proteins, DNA, Fungal, Fungal Proteins, Phosphorylation, Recombination, Genetic, Saccharomyces cerevisiae, Ultraviolet Rays, Gene Expression Regulation, Fungal, Saccharomyces cerevisiae Proteins

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DNA Repair Protein Rad55 Is a Terminal Substrate of the DNA Damage Checkpoints

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