An essential gene, ESR1, is required for mitotic growth, DNA repair and meiotic recombination Saccharomyces cerevisiae

Kato, Ryuichi; Ogawa, Hideyuki

doi:10.1093/nar/22.15.3104

Cited by 218DNA Repair MechanismsFungal and yeast genetics researchMicrotubule and mitosis dynamics

An essential gene, ESR1, is required for mitotic growth, DNA repair and meiotic recombination Saccharomyces cerevisiae

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Kato, Ryuichi, Ogawa, Hideyuki·1994·Nucleic Acids Research

DOI 10.1093/nar/22.15.3104PMC PMC310282

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Abstract

A new mutant, which was sensitive to both methyl-methanesulfonate (MMS) and ultra-violet light (UV) and defective in meiotic recombination, was isolated from Saccharomyces cerevisiae. The gene, ESR1, was cloned by complementation of the MMS sensitivity of the mutant and found to be essential for cell growth, as the deleted haploid strain was lethal. The ESR1 gene was adjacent to the CKS1 gene on chromosome II and encoded a putative 2368-amino acid protein with a molecular weight of 273 k. The ESR1 transcript was 8.0 kb long and was induced during meiosis. The predicted Esr1 protein had a mosaic structure composed of homologous regions and showed amino acid sequence similarities to Schizosaccharomyces pombe rad3+ protein, which monitors completion of DNA repair synthesis, and cut1+ protein, which is required for spindle pole body (SPB) duplication. The Esr1 protein was also similar to phosphatidylinositol (PI) 3-kinases, including Saccharomyces cerevisiae TOR2 (and DRR1), which are involved in G1 progression. These results suggest that ESR1 is multi-functional throughout mitosis and meiosis.

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Authors: Kato, R., & Ogawa, H.
Affiliations: The University of Osaka (JP)
ORCID: Kato, Ryuichi
Ogawa, Hideyuki
Venue: Nucleic Acids Research
Publisher: Oxford University Press (OUP)
Published: 1994
Volume: 22
Issue: 15
Pages: 3104-3112
ISSN: 0305-1048 (ISSN-L)
1362-4962
DOI: 10.1093/nar/22.15.3104
PMC: PMC310282
OpenAlex: W2051503663
Cited by: 218
References: 58
Citations by year: 2026: 2 · 2025: 2 · 2024: 1 · 2023: 3 · 2022: 2 · 2021: 4 · 2020: 1 · 2019: 2 · 2018: 1 · 2017: 3 · 2016: 2 · 2015: 5 · 2014: 1 · 2013: 3 · 2012: 4
FWCI: 7.97
Type: journal article
Language: en
Open access: green
europepmc.org
Locations: Nucleic Acids Research (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
Keywords: ESR1 gene, Saccharomyces cerevisiae, essential genes, meiotic recombination, DNA repair, methyl methanesulfonate sensitivity, UV sensitivity, meiosis, TOR2, phosphatidylinositol 3-kinase
MeSH terms: Amino Acid Sequence, Base Sequence, Cloning, Molecular, DNA Repair, DNA, Fungal, Fungal Proteins, Genes, Fungal, Meiosis, Methyl Methanesulfonate, Mitosis, Molecular Sequence Data, Mutation, Saccharomyces cerevisiae, Transcription, Genetic, Ultraviolet Rays, Blotting, Northern, Restriction Mapping, Protein Serine-Threonine Kinases, Sequence Homology, Saccharomyces cerevisiae Proteins, Intracellular Signaling Peptides and Proteins

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An essential gene, ESR1, is required for mitotic growth, DNA repair and meiotic recombination Saccharomyces cerevisiae

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